The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease

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Fältnamn	Indikatorer	Metadata
000		04340naa a2200445 4500
001		oai:gup.ub.gu.se/320692
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3206922 URI
024	7	a https://doi.org/10.1038/s41569-022-00771-02 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Chakaroun, Rima,d 1983u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xchrim
245	1 0	a The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
264		c 2022-10-14
264	1	b Springer Science and Business Media LLC,c 2023
520		a In this Review, Backhed and colleagues summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit motivating translational approaches to target the gut microbiota and its metabolites for prevention and treatment. Despite milestones in preventive measures and treatment, cardiovascular disease (CVD) remains associated with a high burden of morbidity and mortality. The protracted nature of the development and progression of CVD motivates the identification of early and complementary targets that might explain and alleviate any residual risk in treated patients. The gut microbiota has emerged as a sentinel between our inner milieu and outer environment and relays a modified risk associated with these factors to the host. Accordingly, numerous mechanistic studies in animal models support a causal role of the gut microbiome in CVD via specific microbial or shared microbiota-host metabolites and have identified converging mammalian targets for these signals. Similarly, large-scale cohort studies have repeatedly reported perturbations of the gut microbial community in CVD, supporting the translational potential of targeting this ecological niche, but the move from bench to bedside has not been smooth. In this Review, we provide an overview of the current evidence on the interconnectedness of the gut microbiome and CVD against the noisy backdrop of highly prevalent confounders in advanced CVD, such as increased metabolic burden and polypharmacy. We further aim to conceptualize the molecular mechanisms at the centre of these associations and identify actionable gut microbiome-based targets, while contextualizing the current knowledge within the clinical scenario and emphasizing the limitations of the field that need to be overcome.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a chain fatty-acids
653		a trimethylamine-n-oxide
653		a incident cardiovascular
653		a events
653		a protein-coupled receptor
653		a randomized double-blind
653		a coronary-heart-disease
653		a metabolic syndrome
653		a intestinal microbiota
653		a dietary fiber
653		a all-cause
653		a Cardiovascular System & Cardiology
700	1	a Olsson, Lisa M.,d 1984u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xollit
700	1	a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xbafre
710	2	a Göteborgs universitetb Wallenberglaboratoriet4 org
773	0	t Nature Reviews Cardiologyd : Springer Science and Business Media LLCg 20:4, s. 217-235q 20:4<217-235x 1759-5002x 1759-5010
856	4 8	u https://gup.ub.gu.se/publication/320692
856	4 8	u https://doi.org/10.1038/s41569-022-00771-0

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Av författaren/redakt...: Chakaroun, Rima, ...; Olsson, Lisa M., ...; Bäckhed, Fredrik ...

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