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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006651naa a2200529 4500
001oai:DiVA.org:oru-107636
003SwePub
008230816s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1076362 URI
0247 a https://doi.org/10.1016/j.jgar.2021.11.0072 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Chen, Baoliu Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China4 aut
2451 0a Rapid increase in occurrence of carbapenem-resistant Enterobacteriaceae in healthy rural residents in Shandong Province, China, from 2015 to 2017
264 1b Elsevier,c 2022
338 a print2 rdacarrier
500 a This study was funded by the National Natural Science Foundation of China [41771499, 81361138021], the Swedish Research Council [D0879801], the Swedish Research Council Formas [2016-00640], ALF Grants, Region Östergötland [LIO-793191 and LIO-899871], Shandong Key Research and Development Plan Project [2017GSF218062] and the Medical and Health Technology Development Program of Shandong Province [2017WS447].
520 a OBJECTIVES: The global increase in carbapenem-resistant Enterobacteriaceae (CRE) is a growing health concern. Infections caused by CRE are associated with increased mortality and length of hospital stay, emphasising the health and economic burden posed by these pathogens. Although CRE can inhabit the human gut asymptomatically, colonisation with CRE is associated with an increased risk of CRE infection and mortality. In this study, we investigated the occurrence and characteristics of CRE in faecal samples from healthy persons in 12 villages in Shandong Province, China.METHODS: Screening for CRE in faecal samples was performed by selective cultivation. Minimum inhibitory concentrations (MICs) of meropenem were determined by the agar dilution method. Multilocus sequence typing (MLST) and carbapenemase gene carriage of the isolates were determined by whole-genome sequencing. Genetic relatedness of Escherichia coli isolates was determined by core genome MLST.RESULTS: CRE carriage increased from 2.4% in 2015 to 13.4% in 2017. Most CRE isolates (93.0%) were E. coli and all carried NDM-type carbapenemases. Sequence types (STs) among the E. coli isolates were diverse. The single most common ST was the highly epidemic strain ST167, which was only observed in 2017.CONCLUSION: We report a rapid increase in occurrence of CRE (from 2.4% to 13.4%) among faecal samples collected from healthy rural residents of Shandong Province from 2015 to 2017. Colonisation with CRE is known to increase the risk of CRE infection, and the worrying deterioration of the epidemiological situation in the region reported here indicates a need for further monitoring and possible interventions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653 a Carbapenems
653 a China
653 a Drug resistance
653 a Enterobacteriaceae
653 a Epidemiology
653 a Escherichia coli
7001 a Berglund, Björnu Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State4 aut
7001 a Wang, Shuangu Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China4 aut
7001 a Börjesson, Stefan,d 1979-u Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden4 aut0 (Swepub:oru)sebn
7001 a Bi, Zhenqiangu Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China4 aut
7001 a Nilsson, Maudu Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden4 aut
7001 a Yin, Hongu Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden4 aut
7001 a Zheng, Beiwenu Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated4 aut
7001 a Xiao, Yonghongu Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated4 aut
7001 a Bi, Zhenwangu Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, China; Shandong Academy of Clinical Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China4 aut
7001 a Nilsson, Lennart Eu Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden4 aut
7102 a Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, No. 16992 Jingshi Road, Jinan 250014, Shandong Province, Chinab Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State4 org
7730 t Journal of Global Antimicrobial Resistanced : Elsevierg 28, s. 38-42q 28<38-42x 2213-7165x 2213-7173
8564 u https://doi.org/10.1016/j.jgar.2021.11.007y Fulltext
8564 u https://doi.org/10.1016/j.jgar.2021.11.007
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107636
8564 8u https://doi.org/10.1016/j.jgar.2021.11.007

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