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Characterization of...
Characterization of natural killer cells' cytotoxic heterogeneity using an array of sono-cages
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- Christakou, Athanasia E. (författare)
- KTH,Tillämpad fysik
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- Ohlin, Mathias (författare)
- KTH,Tillämpad fysik
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Kadri, N. (författare)
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visa fler...
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- Frisk, Thomas (författare)
- KTH,Tillämpad fysik
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- Önfelt, Björn (författare)
- KTH,Tillämpad fysik,Karolinska Institute, Sweden
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- Wiklund, Martin (författare)
- KTH,Tillämpad fysik
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visa färre...
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(creator_code:org_t)
- Chemical and Biological Microsystems Society, 2012
- 2012
- Engelska.
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Ingår i: Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. - : Chemical and Biological Microsystems Society. - 9780979806452 ; , s. 1555-1557
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Using a multi-well device as an array of sono-cages for single cell analysis, we quantify for the first time the heterogeneity of natural killer (NK) cells' cytotoxic response against cancer cells. We report a fraction of inactive NK cells within the tested population (36%), as well as the existence of few 'serial killers' that eliminate up to six targets during 4 hours. We also characterize the multi-well acoustic device in terms of trapping efficiency at different actuation voltages, using adherent and non-adherent cell lines. We show that the acoustic forces applied on the cells can be compared to forces of biological processes (i.e. cell adherence).
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- Cytotoxicity
- Microchip
- Multi-well
- Natural killer cells
- Ultrasound
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
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