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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05378naa a2201429 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:141351228 | |
| 003 | SwePub | |
| 008 | 240701s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1413512282 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-019-10898-32 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mourikis, TP4 aut |
| 245 | 1 0 | a Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma |
| 264 | c 2019-07-15 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2019 |
| 520 | a The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy. | |
| 700 | 1 | a Benedetti, L4 aut |
| 700 | 1 | a Foxall, E4 aut |
| 700 | 1 | a Temelkovski, D4 aut |
| 700 | 1 | a Nulsen, J4 aut |
| 700 | 1 | a Perner, J4 aut |
| 700 | 1 | a Cereda, M4 aut |
| 700 | 1 | a Lagergren, Ju Karolinska Institutet4 aut |
| 700 | 1 | a Howell, M4 aut |
| 700 | 1 | a Yau, C4 aut |
| 700 | 1 | a Fitzgerald, RC4 aut |
| 700 | 1 | a Scaffidi, P4 aut |
| 700 | 1 | a Noorani, A4 aut |
| 700 | 1 | a Edwards, PAW4 aut |
| 700 | 1 | a Elliott, RF4 aut |
| 700 | 1 | a Grehan, N4 aut |
| 700 | 1 | a Nutzinger, B4 aut |
| 700 | 1 | a Hughes, C4 aut |
| 700 | 1 | a Fidziukiewicz, E4 aut |
| 700 | 1 | a Bornschein, J4 aut |
| 700 | 1 | a MacRae, S4 aut |
| 700 | 1 | a Crawte, J4 aut |
| 700 | 1 | a Northrop, A4 aut |
| 700 | 1 | a Contino, G4 aut |
| 700 | 1 | a Li, XD4 aut |
| 700 | 1 | a de la Rue, R4 aut |
| 700 | 1 | a Katz-Summercorn, A4 aut |
| 700 | 1 | a Abbas, S4 aut |
| 700 | 1 | a Loureda, D4 aut |
| 700 | 1 | a O'Donovan, M4 aut |
| 700 | 1 | a Miremadi, A4 aut |
| 700 | 1 | a Malhotra, S4 aut |
| 700 | 1 | a Tripathi, M4 aut |
| 700 | 1 | a Tavare, S4 aut |
| 700 | 1 | a Lynch, AG4 aut |
| 700 | 1 | a Eldridge, M4 aut |
| 700 | 1 | a Secrier, M4 aut |
| 700 | 1 | a Bower, L4 aut |
| 700 | 1 | a Devonshire, G4 aut |
| 700 | 1 | a Jammula, S4 aut |
| 700 | 1 | a Davies, J4 aut |
| 700 | 1 | a Crichton, C4 aut |
| 700 | 1 | a Carroll, N4 aut |
| 700 | 1 | a Safranek, P4 aut |
| 700 | 1 | a Hindmarsh, A4 aut |
| 700 | 1 | a Sujendran, V4 aut |
| 700 | 1 | a Hayes, SJ4 aut |
| 700 | 1 | a Ang, Y4 aut |
| 700 | 1 | a Sharrocks, A4 aut |
| 700 | 1 | a Preston, SR4 aut |
| 700 | 1 | a Oakes, S4 aut |
| 700 | 1 | a Bagwan, I4 aut |
| 700 | 1 | a Save, V4 aut |
| 700 | 1 | a Skipworth, RJE4 aut |
| 700 | 1 | a Hupp, TR4 aut |
| 700 | 1 | a O'Neill, JR4 aut |
| 700 | 1 | a Tucker, O4 aut |
| 700 | 1 | a Beggs, A4 aut |
| 700 | 1 | a Taniere, P4 aut |
| 700 | 1 | a Puig, S4 aut |
| 700 | 1 | a Underwood, TJ4 aut |
| 700 | 1 | a Walker, RC4 aut |
| 700 | 1 | a Grace, BL4 aut |
| 700 | 1 | a Barr, H4 aut |
| 700 | 1 | a Shepherd, N4 aut |
| 700 | 1 | a Old, O4 aut |
| 700 | 1 | a Gossage, J4 aut |
| 700 | 1 | a Davies, A4 aut |
| 700 | 1 | a Chang, F4 aut |
| 700 | 1 | a Zylstra, J4 aut |
| 700 | 1 | a Mahadeva, U4 aut |
| 700 | 1 | a Goh, V4 aut |
| 700 | 1 | a Sanders, G4 aut |
| 700 | 1 | a Berrisford, R4 aut |
| 700 | 1 | a Harden, C4 aut |
| 700 | 1 | a Lewis, M4 aut |
| 700 | 1 | a Cheong, E4 aut |
| 700 | 1 | a Kumar, B4 aut |
| 700 | 1 | a Parsons, SL4 aut |
| 700 | 1 | a Soomro, I4 aut |
| 700 | 1 | a Kaye, P4 aut |
| 700 | 1 | a Saunders, J4 aut |
| 700 | 1 | a Lovat, L4 aut |
| 700 | 1 | a Haidry, R4 aut |
| 700 | 1 | a Igali, L4 aut |
| 700 | 1 | a Scott, M4 aut |
| 700 | 1 | a Sothi, S4 aut |
| 700 | 1 | a Suortamo, S4 aut |
| 700 | 1 | a Lishman, S4 aut |
| 700 | 1 | a Hanna, GB4 aut |
| 700 | 1 | a Peters, CJ4 aut |
| 700 | 1 | a Moorthy, K4 aut |
| 700 | 1 | a Grabowska, A4 aut |
| 700 | 1 | a Turkington, R4 aut |
| 700 | 1 | a McManus, D4 aut |
| 700 | 1 | a Khoo, D4 aut |
| 700 | 1 | a Fickling, W4 aut |
| 700 | 1 | a Ciccarelli, FD4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 3101-q 10:1<3101-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-019-10898-3.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141351228 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-019-10898-3 |
Hitta mer i SwePub
- Av författaren/redakt...
- Mourikis, TP
- Benedetti, L
- Foxall, E
- Temelkovski, D
- Nulsen, J
- Perner, J
- visa fler...
- Cereda, M
- Lagergren, J
- Howell, M
- Yau, C
- Fitzgerald, RC
- Scaffidi, P
- Noorani, A
- Edwards, PAW
- Elliott, RF
- Grehan, N
- Nutzinger, B
- Hughes, C
- Fidziukiewicz, E
- Bornschein, J
- MacRae, S
- Crawte, J
- Northrop, A
- Contino, G
- Li, XD
- de la Rue, R
- Katz-Summercorn, ...
- Abbas, S
- Loureda, D
- O'Donovan, M
- Miremadi, A
- Malhotra, S
- Tripathi, M
- Tavare, S
- Lynch, AG
- Eldridge, M
- Secrier, M
- Bower, L
- Devonshire, G
- Jammula, S
- Davies, J
- Crichton, C
- Carroll, N
- Safranek, P
- Hindmarsh, A
- Sujendran, V
- Hayes, SJ
- Ang, Y
- Sharrocks, A
- Preston, SR
- Oakes, S
- Bagwan, I
- Save, V
- Skipworth, RJE
- Hupp, TR
- O'Neill, JR
- Tucker, O
- Beggs, A
- Taniere, P
- Puig, S
- Underwood, TJ
- Walker, RC
- Grace, BL
- Barr, H
- Shepherd, N
- Old, O
- Gossage, J
- Davies, A
- Chang, F
- Zylstra, J
- Mahadeva, U
- Goh, V
- Sanders, G
- Berrisford, R
- Harden, C
- Lewis, M
- Cheong, E
- Kumar, B
- Parsons, SL
- Soomro, I
- Kaye, P
- Saunders, J
- Lovat, L
- Haidry, R
- Igali, L
- Scott, M
- Sothi, S
- Suortamo, S
- Lishman, S
- Hanna, GB
- Peters, CJ
- Moorthy, K
- Grabowska, A
- Turkington, R
- McManus, D
- Khoo, D
- Fickling, W
- Ciccarelli, FD
- visa färre...
- Artiklar i publikationen
- Nature communica ...
- Av lärosätet
- Karolinska Institutet
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