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  • Lao, O.Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands (author)

Correlation between Genetic and Geographic Structure in Europe

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-45434
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45434URI
  • https://doi.org/10.1016/j.cub.2008.07.049DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Understanding the genetic structure of the European population is important, not only from a historical perspective, but also for the appropriate design and interpretation of genetic epidemiological studies. Previous population genetic analyses with autosomal markers in Europe either had a wide geographic but narrow genomic coverage [1, 2], or vice versa [3-6]. We therefore investigated Affymetrix GeneChip 500K genotype data from 2,514 individuals belonging to 23 different subpopulations, widely spread over Europe. Although we found only a low level of genetic differentiation between subpopulations, the existing differences were characterized by a strong continent-wide correlation between geographic and genetic distance. Furthermore, mean heterozygosity was larger, and mean linkage disequilibrium smaller, in southern as compared to northern Europe. Both parameters clearly showed a clinal distribution that provided evidence for a spatial continuity of genetic diversity in Europe. Our comprehensive genetic data are thus compatible with expectations based upon European population history, including the hypotheses of a south-north expansion and/or a larger effective population size in southern than in northern Europe. By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry. © 2008 Elsevier Ltd. All rights reserved.

Subject headings and genre

  • EVOL_ECOL
  • HUM_DISEASE
  • NATURAL SCIENCES
  • NATURVETENSKAP
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lu, T.T.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Nothnagel, M.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Junge, O.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Freitag-Wolf, S.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Caliebe, A.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Balascakova, M.Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic (author)
  • Bertranpetit, J.Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain (author)
  • Bindoff, L.A.Department of Neurology, Haukeland University Hospital, Institute of Clinical Medicine, 5021 Bergen, Norway (author)
  • Comas, D.Unitat de Biologia Evolutiva, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain (author)
  • Holmlund, GunillaLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet,National Board of Forensic Medicine, Linköping, Sweden(Swepub:liu)gunho29 (author)
  • Kouvatsi, A.Department of Genetics, Development, and Molecular Biology, Aristotle University of Thessaloniki, GR-540 06 Thessaloniki, Greece (author)
  • Macek, M.Institute of Biology and Medical Genetics, University Hospital Motol, 2nd School of Medicine, CZ 150 06 Prague 5, Czech Republic (author)
  • Mollet, I.Laboratoire d'Empreintes Génétiques, EFS-RA site de Lyon, 69007 Lyon, France (author)
  • Parson, W.Institute of Legal Medicine, Medical University Innsbruck, A-6020 Innsbruck, Austria (author)
  • Palo, J.Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland (author)
  • Ploski, R.Department of Medical Genetics, Medical University Warsaw, 02-007 Warsaw, Poland (author)
  • Sajantila, A.Department of Forensic Medicine, University of Helsinki, Helsinki, FIN-00014, Finland (author)
  • Tagliabracci, A.Istituto di Medicina Legale, University of Ancona, I-60020 Ancona, Italy (author)
  • Gether, U.Molecular Neuropharmacology Group, Center for Pharmacogenomics Department of Neuroscience and Pharmacology, University of Copenhagen, 2200 Copenhagen, Denmark (author)
  • Werge, T.Research Institute of Biological Psychiatry, Center for Pharmacogenomics, Mental Health Center Sct. Hans, DK-4000 Roskilde, Denmark (author)
  • Rivadeneira, F.Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands (author)
  • Hofman, A.Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands (author)
  • Uitterlinden, A.G.Department of Internal Medicine, Genetics Laboratory, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands, Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands (author)
  • Gieger, C.Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany (author)
  • Wichmann, H.-E.Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians University, D-81377 Munich, Germany (author)
  • Ruther, A.Rüther, A., Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Schreiber, S.Institut für Medizinische Molekularbiologie, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Becker, C.Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany (author)
  • Nurnberg, P.Nürnberg, P., Cologne Center for Genomics, Institut für Genetik, University of Cologne, D-50674 Cologne, Germany (author)
  • Nelson, M.R.Genetics, GlaxoSmithKline, Research Triangle Park, NC 27709, United States (author)
  • Krawczak, M.Institut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (author)
  • Kayser, M.Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, Netherlands (author)
  • Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, NetherlandsInstitut für Medizinische Informatik und Statistik, Christian-Albrechts University Kiel, D-24105 Kiel, Germany (creator_code:org_t)

Related titles

  • In:Current Biology: Elsevier BV18:16, s. 1241-12480960-98221879-0445

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