WFRF:(Dalca A.)
Sökning: WFRF:(Dalca A.) > Deep profiling of m...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09011naa a2201201 4500 | |
| 001 | oai:gup.ub.gu.se/320306 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:960d432a-1584-4ba0-8072-4691e49de93f | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3203062 URI |
| 024 | 7 | a https://doi.org/10.3389/fnins.2022.9944582 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/960d432a-1584-4ba0-8072-4691e49de93f2 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bonkhoff, A. K.u Harvard Medical School,Massachusetts General Hospital4 aut |
| 245 | 1 0 | a Deep profiling of multiple ischemic lesions in a large, multi-center cohort: Frequency, spatial distribution, and associations to clinical characteristics |
| 264 | c 2022-08-25 | |
| 264 | 1 | b Frontiers Media SA,c 2022 |
| 520 | a Background purposeA substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort. Materials and methodsAnalyses relied upon imaging and clinical data from the international MRI-GENIE study. Imaging data comprised both Fluid-attenuated inversion recovery (FLAIR) for white matter hyperintensity (WMH) burden estimation and diffusion-weighted imaging (DWI) sequences for the assessment of acute stroke lesions. The initial step featured the systematic evaluation of occurrences of MAL within one and several vascular supply territories. Associations between MAL and important imaging and clinical characteristics were subsequently determined. The interaction effect between single and multiple lesion status and lesion volume was estimated by means of Bayesian hierarchical regression modeling for both stroke severity and functional outcome. ResultsWe analyzed 2,466 patients (age = 63.4 +/- 14.8, 39% women), 49.7% of which presented with a single lesion. Another 37.4% experienced MAL in a single vascular territory, while 12.9% featured lesions in multiple vascular territories. Within most territories, MAL occurred as frequently as single lesions (ratio similar to 1:1). Only the brainstem region comprised fewer patients with MAL (ratio 1:4). Patients with MAL presented with a significantly higher lesion volume and acute NIHSS (7.7 vs. 1.7 ml and 4 vs. 3, p(FDR) < 0.001). In contrast, patients with a single lesion were characterized by a significantly higher WMH burden (6.1 vs. 5.3 ml, p(FDR) = 0.048). Functional outcome did not differ significantly between patients with single versus multiple lesions. Bayesian analyses suggested that the association between lesion volume and stroke severity between single and multiple lesions was the same in case of anterior circulation stroke. In case of posterior circulation stroke, lesion volume was linked to a higher NIHSS only among those with MAL. ConclusionMultiple lesions, especially those within one vascular territory, occurred more frequently than previously reported. Overall, multiple lesions were distinctly linked to a higher acute stroke severity, a higher total DWI lesion volume and a lower WMH lesion volume. In posterior circulation stroke, lesion volume was linked to a higher stroke severity in multiple lesions only. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a magnetic resonance imaging | |
| 653 | a acute ischemic stroke | |
| 653 | a lesion volume | |
| 653 | a multiple acute ischemic lesions | |
| 653 | a quantitative imaging | |
| 653 | a Bayesian | |
| 653 | a hierarchical regression | |
| 653 | a acute cerebral infarcts | |
| 653 | a acute stroke | |
| 653 | a independent predictor | |
| 653 | a brain | |
| 653 | a infarcts | |
| 653 | a diffusion | |
| 653 | a volumes | |
| 653 | a circulations | |
| 653 | a system | |
| 653 | a Neurosciences & Neurology | |
| 653 | a Bayesian hierarchical regression | |
| 700 | 1 | a Ullberg, T.u Lund University,Lunds universitet,Stroke policy och kvalitetsregisterforskning,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Stroke policy and quality register research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tsu |
| 700 | 1 | a Bretzner, M.4 aut |
| 700 | 1 | a Hong, S. M.4 aut |
| 700 | 1 | a Schirmer, M. D.4 aut |
| 700 | 1 | a Regenhardt, R. W.4 aut |
| 700 | 1 | a Donahue, K. L.4 aut |
| 700 | 1 | a Nardin, M. J.4 aut |
| 700 | 1 | a Dalca, A. V.4 aut |
| 700 | 1 | a Giese, A. K.4 aut |
| 700 | 1 | a Etherton, M. R.4 aut |
| 700 | 1 | a Hancock, B. L.4 aut |
| 700 | 1 | a Stanne, Tara M,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xmcdta |
| 700 | 1 | a McIntosh, E. C.4 aut |
| 700 | 1 | a Attia, J.4 aut |
| 700 | 1 | a Wasselius, J.u Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Neuroradiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)oft-jws |
| 700 | 1 | a Donatti, A.4 aut |
| 700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xjerch |
| 700 | 1 | a Heitsch, L.4 aut |
| 700 | 1 | a Holmegaard, Lukasu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xhollu |
| 700 | 1 | a Jood, Katarina,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjooka |
| 700 | 1 | a Jimenez-Conde, J.4 aut |
| 700 | 1 | a Kittner, S. J.4 aut |
| 700 | 1 | a Lemmens, R.4 aut |
| 700 | 1 | a Levi, C. R.4 aut |
| 700 | 1 | a McDonough, C. W.4 aut |
| 700 | 1 | a Meschia, J. F.4 aut |
| 700 | 1 | a Phuah, C. L.4 aut |
| 700 | 1 | a Ropele, S.4 aut |
| 700 | 1 | a Rosand, J.4 aut |
| 700 | 1 | a Roquer, J.4 aut |
| 700 | 1 | a Rundek, T.4 aut |
| 700 | 1 | a Sacco, R. L.4 aut |
| 700 | 1 | a Schmidt, R.4 aut |
| 700 | 1 | a Sharma, P.4 aut |
| 700 | 1 | a Slowik, A.4 aut |
| 700 | 1 | a Sousa, A.4 aut |
| 700 | 1 | a Stanne, Tara M,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xmcdta |
| 700 | 1 | a Strbian, D.4 aut |
| 700 | 1 | a Tatlisumak, T.4 aut |
| 700 | 1 | a Thijs, V.4 aut |
| 700 | 1 | a Vagal, A.4 aut |
| 700 | 1 | a Woo, D.4 aut |
| 700 | 1 | a Zand, R.4 aut |
| 700 | 1 | a Frid, P.u Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Stroke Imaging Research group,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups4 aut0 (Swepub:lu)med-ptf |
| 700 | 1 | a Worrall, B. B.4 aut |
| 700 | 1 | a Jern, Christina,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xjerch |
| 700 | 1 | a Lindgren, A.G.u Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)neur-ali |
| 700 | 1 | a Maguire, J.4 aut |
| 700 | 1 | a Wu, O.4 aut |
| 700 | 1 | a Frid, P.4 aut |
| 700 | 1 | a Rost, N. S.4 aut |
| 700 | 1 | a Wasselius, J.4 aut |
| 710 | 2 | a Harvard Medical Schoolb Massachusetts General Hospital4 org |
| 710 | 2 | a International Stroke Genetics Consortium |
| 773 | 0 | t Frontiers in Neuroscienced : Frontiers Media SAg 16q 16x 1662-453Xx 1662-4548 |
| 856 | 4 | u http://dx.doi.org/10.3389/fnins.2022.994458x freey FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/320306 |
| 856 | 4 8 | u https://doi.org/10.3389/fnins.2022.994458 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/960d432a-1584-4ba0-8072-4691e49de93f |
Hitta via bibliotek
- Frontiers in Neuroscience (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
Hitta mer i SwePub
- Av författaren/redakt...
- Bonkhoff, A. K.
- Ullberg, T.
- Bretzner, M.
- Hong, S. M.
- Schirmer, M. D.
- Regenhardt, R. W ...
- visa fler...
- Donahue, K. L.
- Nardin, M. J.
- Dalca, A. V.
- Giese, A. K.
- Etherton, M. R.
- Hancock, B. L.
- Stanne, Tara M, ...
- McIntosh, E. C.
- Attia, J.
- Wasselius, J.
- Donatti, A.
- Jern, Christina, ...
- Heitsch, L.
- Holmegaard, Luka ...
- Jood, Katarina, ...
- Jimenez-Conde, J ...
- Kittner, S. J.
- Lemmens, R.
- Levi, C. R.
- McDonough, C. W.
- Meschia, J. F.
- Phuah, C. L.
- Ropele, S.
- Rosand, J.
- Roquer, J.
- Rundek, T.
- Sacco, R. L.
- Schmidt, R.
- Sharma, P.
- Slowik, A.
- Sousa, A.
- Strbian, D.
- Tatlisumak, T.
- Thijs, V.
- Vagal, A.
- Woo, D.
- Zand, R.
- Frid, P.
- Worrall, B. B.
- Lindgren, A.G.
- Maguire, J.
- Wu, O.
- Rost, N. S.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Neurovetenskaper
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Neurologi
- Artiklar i publikationen
- Frontiers in Neu ...
- Av lärosätet
- Göteborgs universitet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
