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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008877naa a2200925 4500
001oai:DiVA.org:umu-222894
003SwePub
008240405s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2228942 URI
0247 a https://doi.org/10.1016/j.euros.2024.02.0192 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rajwa, Pawelu Department of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria4 aut
2451 0a Research protocol for an observational health data analysis on the adverse events of systemic treatment in patients with metastatic hormone-sensitive prostate cancer :b big data analytics using the PIONEER platform
264 1b Elsevier,c 2024
338 a electronic2 rdacarrier
520 a Combination therapies in metastatic hormone-sensitive prostate cancer (mHSPC), which include the addition of an androgen receptor signaling inhibitor and/or docetaxel to androgen deprivation therapy, have been a game changer in the management of this disease stage. However, these therapies come with their fair share of toxicities and side effects. The goal of this observational study is to report drug-related adverse events (AEs), which are correlated with systemic combination therapies for mHSPC. Determining the optimal treatment option requires large cohorts to estimate the tolerability and AEs of these combination therapies in “real-life” patients with mHSPC, as provided in this study. We use a network of databases that includes population-based registries, electronic health records, and insurance claims, containing the overall target population and subgroups of patients defined by unique certain characteristics, demographics, and comorbidities, to compute the incidence of common AEs associated with systemic therapies in the setting of mHSPC. These data sources are standardised using the Observational Medical Outcomes Partnership Common Data Model. We perform the descriptive statistics as well as calculate the AE incidence rate separately for each treatment group, stratified by age groups and index year. The time until the first event is estimated using the Kaplan-Meier method within each age group. In the case of episodic events, the anticipated mean cumulative counts of events are calculated. Our study will allow clinicians to tailor optimal therapies for mHSPC patients, and they will serve as a basis for comparative method studies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Androgen receptor signaling inhibitor
653 a Big data
653 a Docetaxel
653 a Hormone sensitive
653 a Metastatic
653 a PIONEER
653 a Prostate cancer
7001 a Borkowetz, Angelikau Department of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany4 aut
7001 a Abbott, Thomasu European Association of Urology, Nijmegen, Netherlands4 aut
7001 a Alberti, Andreau Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut
7001 a Bjartell, Andersu Department of Translational Medicine, Lund University, Lund, Sweden4 aut
7001 a Brash, James T.u IQVIA, Real World Solutions, Brighton, United Kingdom4 aut
7001 a Campi, Riccardou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut
7001 a Chilelli, Andrewu Astellas Pharma Europe Ltd, Surrey, United Kingdom4 aut
7001 a Conover, Mitchellu Janssen Research & Development, NJ, Titusville, United States4 aut
7001 a Constantinovici, Niculaeu Bayer AG, Berlin, Germany4 aut
7001 a Davies, Eleanoru IQVIA, Real World Solutions, Brighton, United Kingdom4 aut
7001 a De Meulder, Bertrandu Association EISBM, Vourles, France4 aut
7001 a Eid, Sherrineu SAS Institute, NC, Cary, United States4 aut
7001 a Gacci, Maurou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut
7001 a Golozar, Asiehu Odysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States4 aut
7001 a Hafeez, Haroonu Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar, Pakistan4 aut
7001 a Haque, Samiulu SAS Institute, NC, Cary, United States4 aut
7001 a Hijazy, Aymanu Association EISBM, Vourles, France4 aut
7001 a Hulsen, Timu Department of Hospital Services & Informatics, Philips Research, Eindhoven, Netherlands4 aut
7001 a Josefsson, Andreas,d 1979-u Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för diagnostik och intervention,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:umu)aasjon01
7001 a Khalid, Sarau University of Oxford, Oxford, United Kingdom4 aut
7001 a Kolde, Raivou Institute of Computer Science, University of Tartu, Estonia, Tartu, Estonia4 aut
7001 a Kotik, Danielu Center for Advanced Systems Understanding, Görlitz, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany4 aut
7001 a Kurki, Samuu Bayer OY, Turku, Finland4 aut
7001 a Lambrecht, Marku SAS Institute, NC, Cary, United States4 aut
7001 a Leung, Chi-Hou S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong4 aut
7001 a Moreno, Juliau SAS Institute, NC, Cary, United States4 aut
7001 a Nicoletti, Rossellau Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut
7001 a Nieboer, Daanu Erasmus MC University Medical Center, Rotterdam, Netherlands4 aut
7001 a Oja, Mareku Institute of Computer Science, University of Tartu, Estonia, Tartu, Estonia4 aut
7001 a Palanisamy, Soundaryau SAS Institute, NC, Cary, United States4 aut
7001 a Prinsen, Peteru Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands4 aut
7001 a Reich, Christianu Odysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States4 aut
7001 a Raffaele Resta, Giuliou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut
7001 a Ribal, Maria J.u Uro-Oncology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain4 aut
7001 a Gómez Rivas, Juanu Department of Urology, Hospital Clinico San Carlos, Madrid, Spain4 aut
7001 a Smith, Emmau Guidelines Office, European Association of Urology, Arnhem, Netherlands4 aut
7001 a Snijder, Robertu Janssen Research & Development, NJ, Titusville, United States4 aut
7001 a Steinbeisser, Carlu Collaborate Project Management, Munich, Germany4 aut
7001 a Vandenberghe, Frederiku SAS Institute, NC, Cary, United States4 aut
7001 a Cornford, Philipu Liverpool University Hospitals NHS Trust, Liverpool, United Kingdom4 aut
7001 a Evans-Axelsson, Susanu Bayer AG, Berlin, Germany4 aut
7001 a N'Dow, Jamesu Academic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom4 aut
7001 a Willemse, Peter-Paul M.u Department of Urology, Cancer Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut
7102 a Department of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austriab Department of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany4 org
7730 t European Urology Open Scienced : Elsevierg 63, s. 81-88q 63<81-88x 2666-1691x 2666-1683
8564 u https://doi.org/10.1016/j.euros.2024.02.019y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1848929/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222894
8564 8u https://doi.org/10.1016/j.euros.2024.02.019

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