Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

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Fältnamn	Indikatorer	Metadata
000		05989naa a2201069 4500
001		oai:DiVA.org:uu-256992
003		SwePub
008		150629s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-106491
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2569922 URI
024	7	a https://doi.org/10.1093/hmg/ddv0972 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1064912 URI
040		a (SwePub)uud (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Nead, Kevin T.4 aut
245	1 0	a Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity :b a systematic review and meta-analysis with evidence from up to 331 175 individuals
264		c 2015-03-17
264	1	b Oxford University Press (OUP),c 2015
338		a print2 rdacarrier
520		a Polymorphisms rs6232 and rs6234/rs6235 in PCSK1 have been associated with extreme obesity [e.g. body mass index (BMI) a parts per thousand yen 40 kg/m(2)], but their contribution to common obesity (BMI a parts per thousand yen 30 kg/m(2)) and BMI variation in a multi-ethnic context is unclear. To fill this gap, we collected phenotypic and genetic data in up to 331 175 individuals from diverse ethnic groups. This process involved a systematic review of the literature in PubMed, Web of Science, Embase and the NIH GWAS catalog complemented by data extraction from pre-existing GWAS or custom-arrays in consortia and single studies. We employed recently developed global meta-analytic random-effects methods to calculate summary odds ratios (OR) and 95% confidence intervals (CIs) or beta estimates and standard errors (SE) for the obesity status and BMI analyses, respectively. Significant associations were found with binary obesity status for rs6232 (OR = 1.15, 95% CI 1.06-1.24, P = 6.08 x 10(-6)) and rs6234/rs6235 (OR = 1.07, 95% CI 1.04-1.10, P = 3.00 x 10(-7)). Similarly, significant associations were found with continuous BMI for rs6232 (beta = 0.03, 95% CI 0.00-0.07; P = 0.047) and rs6234/rs6235 (beta = 0.02, 95% CI 0.00-0.03; P = 5.57 x 10(-4)). Ethnicity, age and study ascertainment significantly modulated the association of PCSK1 polymorphisms with obesity. In summary, we demonstrate evidence that common gene variation in PCSK1 contributes to BMI variation and susceptibility to common obesity in the largest known meta-analysis published to date in genetic epidemiology.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Li, Aihua4 aut
700	1	a Wehner, Mackenzie R.4 aut
700	1	a Neupane, Binod4 aut
700	1	a Gustafsson, Stefan4 aut
700	1	a Butterworth, Adam4 aut
700	1	a Engert, James C.4 aut
700	1	a Davis, A. Darlene4 aut
700	1	a Hegele, Robert A.u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut
700	1	a Miller, Ruby4 aut
700	1	a den Hoed, Marcel4 aut
700	1	a Khaw, Kay-Tee4 aut
700	1	a Kilpelaeinen, Tuomas O.4 aut
700	1	a Wareham, Nick4 aut
700	1	a Edwards, Todd L.4 aut
700	1	a Hallmans, Goeranu Umeå universitet,Enheten för biobanksforskning,Näringsforskning4 aut
700	1	a Varga, Tibor V.u Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut
700	1	a Kardia, Sharon L. R.4 aut
700	1	a Smith, Jennifer A.4 aut
700	1	a Zhao, Wei4 aut
700	1	a Faul, Jessica D.4 aut
700	1	a Weir, David4 aut
700	1	a Mi, Jieu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut
700	1	a Xi, Bo4 aut
700	1	a Quinteros, Samuel Canizales4 aut
700	1	a Cooper, Cyrus4 aut
700	1	a Sayer, Avan Aihie4 aut
700	1	a Jameson, Karen4 aut
700	1	a Grontved, Anders4 aut
700	1	a Fornage, Myriam4 aut
700	1	a Sidney, Stephen4 aut
700	1	a Hanis, Craig L.4 aut
700	1	a Highland, Heather M.4 aut
700	1	a Haering, Hans-Ulrich4 aut
700	1	a Heni, Martin4 aut
700	1	a Lasky-Su, Jessica4 aut
700	1	a Weiss, Scott T.4 aut
700	1	a Gerhard, Glenn S.4 aut
700	1	a Still, Christopher4 aut
700	1	a Melka, Melkaey M.4 aut
700	1	a Pausova, Zdenka4 aut
700	1	a Paus, Tomas4 aut
700	1	a Grant, Struan F. A.4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Price, R. Arlen4 aut
700	1	a Wang, Kai4 aut
700	1	a Scherag, Andre4 aut
700	1	a Hebebrand, Johannes4 aut
700	1	a Hinney, Anke4 aut
700	1	a Franks, Paul W.4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a McCarthy, Mark I.4 aut
700	1	a Hirschhorn, Joel N.4 aut
700	1	a Loos, Ruth J.4 aut
700	1	a Ingelsson, Erik4 aut
700	1	a Gerstein, Hertzel C.4 aut
700	1	a Yusuf, Salim4 aut
700	1	a Beyene, Joseph4 aut
700	1	a Anand, Sonia S.4 aut
700	1	a Meyre, David4 aut
710	2	a Uppsala universitetb Molekylär epidemiologi4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 24:12, s. 3582-3594q 24:12<3582-3594x 0964-6906x 1460-2083
856	4	u https://academic.oup.com/hmg/article-pdf/24/12/3582/1725326/ddv097.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-256992
856	4 8	u https://doi.org/10.1093/hmg/ddv097
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106491

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Av författaren/redakt...: Nead, Kevin T.; Li, Aihua; Wehner, Mackenzi ...; Neupane, Binod; Gustafsson, Stef ...; Butterworth, Ada ...; visa fler...; Engert, James C.; Davis, A. Darlen ...; Hegele, Robert A ...; Miller, Ruby; den Hoed, Marcel; Khaw, Kay-Tee; Kilpelaeinen, Tu ...; Wareham, Nick; Edwards, Todd L.; Hallmans, Goeran; Varga, Tibor V.; Kardia, Sharon L ...; Smith, Jennifer ...; Zhao, Wei; Faul, Jessica D.; Weir, David; Mi, Jie; Xi, Bo; Quinteros, Samue ...; Cooper, Cyrus; Sayer, Avan Aihi ...; Jameson, Karen; Grontved, Anders; Fornage, Myriam; Sidney, Stephen; Hanis, Craig L.; Highland, Heathe ...; Haering, Hans-Ul ...; Heni, Martin; Lasky-Su, Jessic ...; Weiss, Scott T.; Gerhard, Glenn S ...; Still, Christoph ...; Melka, Melkaey M ...; Pausova, Zdenka; Paus, Tomas; Grant, Struan F. ...; Hakonarson, Hako ...; Price, R. Arlen; Wang, Kai; Scherag, Andre; Hebebrand, Johan ...; Hinney, Anke; Franks, Paul W.; Frayling, Timoth ...; McCarthy, Mark I ...; Hirschhorn, Joel ...; Loos, Ruth J.; Ingelsson, Erik; Gerstein, Hertze ...; Yusuf, Salim; Beyene, Joseph; Anand, Sonia S.; Meyre, David; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Medicinsk biotek ...

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