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Incorporating radio...
Incorporating radiomics into clinical trials : expert consensus endorsed by the European Society of Radiology on considerations for data-driven compared to biologically driven quantitative biomarkers
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- Fournier, Laure (författare)
- Univ Paris, France; European Soc Radiol, Austria; European Org Res & Treatment Canc EORTC, Belgium
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- Costaridou, Lena (författare)
- European Soc Radiol, Austria; Univ Patras, Greece
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- Bidaut, Luc (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Univ Lincoln, England
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- Michoux, Nicolas (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Univ Catholique Louvain UCLouvain, Belgium
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- Lecouvet, Frederic E. (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Univ Catholique Louvain UCLouvain, Belgium
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- de Geus-Oei, Lioe-Fee (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Leiden Univ, Netherlands; Univ Twente, Netherlands
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- Boellaard, Ronald (författare)
- European Soc Radiol, Austria; Vrije Univ Amsterdam, Netherlands; Radiol Soc North Amer, IL USA
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- Oprea-Lager, Daniela E. (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Vrije Univ Amsterdam, Netherlands
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- Obuchowski, Nancy A. (författare)
- Radiol Soc North Amer, IL USA; Cleveland Clin, OH 44106 USA
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- Caroli, Anna (författare)
- European Soc Radiol, Austria; Ist Ric Farmacol Mario Negri IRCCS, Italy
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- Kunz, Wolfgang G. (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Ludwig Maximilians Univ Munchen, Germany
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- Oei, Edwin H. (författare)
- European Soc Radiol, Austria; Univ Med Ctr, Netherlands
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- OConnor, James P. B. (författare)
- European Soc Radiol, Austria; Univ Manchester, England
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- Mayerhoefer, Marius E. (författare)
- European Soc Radiol, Austria; Med Univ Vienna, Austria
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- Franca, Manuela (författare)
- European Soc Radiol, Austria; Univ Porto, Portugal
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- Alberich-Bayarri, Angel (författare)
- European Soc Radiol, Austria; Quantitat Imaging Biomarkers Med QUIBIM, Spain
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- Deroose, Christophe M. (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Univ Hosp Leuven, Belgium; Katholieke Univ Leuven, Belgium
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- Loewe, Christian (författare)
- European Soc Radiol, Austria; Med Univ Vienna, Austria
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- Manniesing, Rashindra (författare)
- European Soc Radiol, Austria; Radboud Univ Nijmegen, Netherlands
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- Caramella, Caroline (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Univ Paris Saclay, France
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- Lopci, Egesta (författare)
- European Org Res & Treatment Canc EORTC, Belgium; Humanitas Clin & Res Hosp IRCCS, Italy
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- Lassau, Nathalie (författare)
- European Soc Radiol, Austria; European Org Res & Treatment Canc EORTC, Belgium; Radiol Soc North Amer, IL USA; Univ Paris Saclay, France
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- Persson, Anders (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping,European Soc Radiol, Austria
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- Achten, Rik (författare)
- European Soc Radiol, Austria; Ghent Univ Hosp, Belgium
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- Rosendahl, Karen (författare)
- European Soc Radiol, Austria; Univ Hosp North Norway, Norway
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- Clement, Olivier (författare)
- European Soc Radiol, Austria
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- Kotter, Elmar (författare)
- European Soc Radiol, Austria; Univ Med Ctr Freiburg, Germany
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- Golay, Xavier (författare)
- European Soc Radiol, Austria; Radiol Soc North Amer, IL USA; UCL, England
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- Smits, Marion (författare)
- European Soc Radiol, Austria; European Org Res & Treatment Canc EORTC, Belgium; Univ Med Ctr, Netherlands
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- Dewey, Marc (författare)
- European Soc Radiol, Austria; Charite Univ Med Berlin, Germany
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- Sullivan, Daniel C. (författare)
- European Soc Radiol, Austria; Radiol Soc North Amer, IL USA; Duke Univ, NC 27710 USA
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- van der Lugt, Aad (författare)
- European Soc Radiol, Austria; Univ Med Ctr, Netherlands
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- deSouza, Nandita M. (författare)
- European Soc Radiol, Austria; European Org Res & Treatment Canc EORTC, Belgium; Radiol Soc North Amer, IL USA; Inst Canc Res, England; Royal Marsden NHS Fdn Trust, England
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(creator_code:org_t)
- 2021-01-25
- 2021
- Engelska.
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Ingår i: European Radiology. - : SPRINGER. - 0938-7994 .- 1432-1084. ; 31:8, s. 6001-6012
- Relaterad länk:
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http://urn.kb.se/res...
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https://liu.diva-por... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissue characteristics and follow a well-understood path of technical, biological and clinical validation before incorporation into clinical trials. In radiomics, novel data-driven processes extract numerous visually imperceptible statistical features from the imaging data with no a priori assumptions on their correlation with biological processes. The selection of relevant features (radiomic signature) and incorporation into clinical trials therefore requires additional considerations to ensure meaningful imaging endpoints. Also, the number of radiomic features tested means that power calculations would result in sample sizes impossible to achieve within clinical trials. This article examines how the process of standardising and validating data-driven imaging biomarkers differs from those based on biological associations. Radiomic signatures are best developed initially on datasets that represent diversity of acquisition protocols as well as diversity of disease and of normal findings, rather than within clinical trials with standardised and optimised protocols as this would risk the selection of radiomic features being linked to the imaging process rather than the pathology. Normalisation through discretisation and feature harmonisation are essential pre-processing steps. Biological correlation may be performed after the technical and clinical validity of a radiomic signature is established, but is not mandatory. Feature selection may be part of discovery within a radiomics-specific trial or represent exploratory endpoints within an established trial; a previously validated radiomic signature may even be used as a primary/secondary endpoint, particularly if associations are demonstrated with specific biological processes and pathways being targeted within clinical trials.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Radiology; Statistics and numerical data; Standardization; Validation studies; Clinical trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Fournier, Laure
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Costaridou, Lena
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Bidaut, Luc
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Michoux, Nicolas
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Lecouvet, Freder ...
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de Geus-Oei, Lio ...
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visa fler...
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Boellaard, Ronal ...
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Oprea-Lager, Dan ...
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Obuchowski, Nanc ...
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Caroli, Anna
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Kunz, Wolfgang G ...
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Oei, Edwin H.
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OConnor, James P ...
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Mayerhoefer, Mar ...
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Franca, Manuela
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Alberich-Bayarri ...
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Deroose, Christo ...
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Loewe, Christian
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Manniesing, Rash ...
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Caramella, Carol ...
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Lopci, Egesta
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Lassau, Nathalie
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Persson, Anders
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Achten, Rik
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Rosendahl, Karen
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Clement, Olivier
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Kotter, Elmar
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Golay, Xavier
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Smits, Marion
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Dewey, Marc
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Sullivan, Daniel ...
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van der Lugt, Aa ...
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deSouza, Nandita ...
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