Search: WFRF:(Dolores Chirlaque López María) >
Interaction between...
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Löfvenborg, Josefin E.Karolinska Institutet,Karolinska Institute
(author)
Interaction between gad65 antibodies and dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acids on incident adult-onset diabetes : The epic-interact study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-12-10
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American Diabetes Association,2021
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9 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:ff505ed1-9baa-4b9e-a0ee-01661c690eb8
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https://lup.lub.lu.se/record/ff505ed1-9baa-4b9e-a0ee-01661c690eb8URI
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https://doi.org/10.2337/dc20-1463DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180256URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145691242URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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OBJECTIVE: Islet autoimmunity is associated with diabetes incidence. We investigated whether there was an interaction between dietary fish intake or plasma phospholipid n-3 polyunsaturated fatty acid (PUFA) concentration with the 65-kDa isoform of GAD (GAD65) antibody positivity on the risk of developing adult-onset diabetes. RESEARCH DESIGN AND METHODS: We used prospective data on 11,247 incident cases of adult-onset diabetes and 14,288 noncases from the EPIC-InterAct case-cohort study conducted in eight European countries. Baseline plasma samples were analyzed for GAD65 antibodies and phospholipid n-3 PUFAs. Adjusted hazard ratios (HRs) for incident diabetes in relation to GAD65 antibody status and tertiles of plasma phospholipid n-3 PUFA or fish intake were estimated using Prentice-weighted Cox regression. Additive (proportion attributable to interaction [AP]) and multiplicative interactions between GAD65 antibody positivity (≥65 units/mL) and low fish/n-3 PUFA were assessed. RESULTS: The hazard of diabetes in antibody-positive individuals with low intake of total and fatty fish, respectively, was significantly elevated (HR 2.52 [95% CI 1.76-3.63] and 2.48 [1.79-3.45]) compared with people who were GAD65 antibody negative and had high fish intake, with evidence of additive (AP 0.44 [95% CI 0.16-0.72] and 0.48 [0.24-0.72]) and multiplicative (P 5 0.0465 and 0.0103) interactions. Individuals with high GAD65 antibody levels (≥167.5 units/mL) and low total plasma phospholipid n-3 PUFAs had a more than fourfold higher hazard of diabetes (HR 4.26 [2.70-6.72]) and an AP of 0.46 (0.12-0.80) compared with antibody-negative individuals with high n-3 PUFAs. CONCLUSIONS: High fish intake or relative plasma phospholipid n-3 PUFA concentrations may partially counteract the increased diabetes risk conferred by GAD65 antibody positivity.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Carlsson, SofiaKarolinska Institutet,Karolinska Institute
(author)
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Andersson, TomasKarolinska Institutet,Stockholm County Council,Karolinska Institute
(author)
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Hampe, Christiane S.University of Washington
(author)
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Koulman, AlbertUniversity of Cambridge
(author)
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Lopez, María Dolores ChirlaqueCIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council,University of Murcia
(author)
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Jakszyn, PaulaRamon Llull University,L'Hospitalet de Llobregat, Barcelona
(author)
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Katzke, Verena A.German Cancer Research Centre
(author)
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Kühn, TilmanGerman Cancer Research Centre
(author)
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Kyrø, CecilieDanish Cancer Society
(author)
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Masala, GiovannaInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(author)
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Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni
(author)
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Overvad, KimAalborg University Hospital,Aarhus University
(author)
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Panico, SalvatoreUniversity of Naples Federico II
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Sánchez, Maria JoseUniversity of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
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Van Der Schouw, YvonneUniversity Medical Center Utrecht
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Schulze, Matthias B.University of Potsdam,German Center for Diabetes Research,German Institute of Human Nutrition
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Tjønneland, AnneUniversity of Copenhagen,Danish Cancer Society
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Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization
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Riboli, ElioImperial College London
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Forouhi, Nita G.University of Cambridge
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Sharp, Stephen J.University of Cambridge
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Rolandsson, OlovUmeå universitet,Umeå University,Allmänmedicin(Swepub:umu)olro0005
(author)
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Wareham, Nicholas J.University of Cambridge
(author)
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Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
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In:Diabetes Care: American Diabetes Association44:2, s. 416-4240149-59921935-5548
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Löfvenborg, Jose ...
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Carlsson, Sofia
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Andersson, Tomas
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Hampe, Christian ...
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Lopez, María Dol ...
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Jakszyn, Paula
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Katzke, Verena A ...
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Kühn, Tilman
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Kyrø, Cecilie
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Masala, Giovanna
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Nilsson, Peter M ...
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Overvad, Kim
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Panico, Salvator ...
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Sánchez, Maria J ...
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Van Der Schouw, ...
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Schulze, Matthia ...
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Tjønneland, Anne
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Weiderpass, Elis ...
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Riboli, Elio
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Forouhi, Nita G.
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Diabetes Care
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