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Sökning: WFRF:(Ebmeier Klaus P.) > (2022) > Brain aging differs...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007138naa a2200565 4500
001oai:DiVA.org:umu-198903
003SwePub
008220905s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1989032 URI
0247 a https://doi.org/10.1038/s41598-022-17727-62 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Walhovd, Kristine B.u Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
2451 0a Brain aging differs with cognitive ability regardless of education
264 c 2022-08-16
264 1b Nature Publishing Group,c 2022
338 a electronic2 rdacarrier
520 a Higher general cognitive ability (GCA) is associated with lower risk of neurodegenerative disorders, but neural mechanisms are unknown. GCA could be associated with more cortical tissue, from young age, i.e. brain reserve, or less cortical atrophy in adulthood, i.e. brain maintenance. Controlling for education, we investigated the relative association of GCA with reserve and maintenance of cortical volume, -area and -thickness through the adult lifespan, using multiple longitudinal cognitively healthy brain imaging cohorts (n = 3327, 7002 MRI scans, baseline age 20–88 years, followed-up for up to 11 years). There were widespread positive relationships between GCA and cortical characteristics (level-level associations). In select regions, higher baseline GCA was associated with less atrophy over time (level-change associations). Relationships remained when controlling for polygenic scores for both GCA and education. Our findings suggest that higher GCA is associated with cortical volumes by both brain reserve and -maintenance mechanisms through the adult lifespan.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Neurology
653 a neurologi
7001 a Nyberg, Lars,d 1966-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för strålningsvetenskaper,Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut0 (Swepub:umu)lany0001
7001 a Lindenberger, Ulmanu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research, London, United Kingdom4 aut
7001 a Amlien, Inge K.u Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Sørensen, Øysteinu Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Wang, Yunpengu Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Mowinckel, Athanasia M.u Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Kievit, Rogier A.u Cognitive Neuroscience Department, Donders Institute for Brain, Cognition and Behavior, The Netherlands, Radboud University Medical Center, Nijmegen, Netherlands4 aut
7001 a Ebmeier, Klaus P.u Department of Psychiatry, University of Oxford, Oxford, United Kingdom4 aut
7001 a Bartrés-Faz, Davidu Department of Medicine, Faculty of Medicine and Health Sciences & Institute of Neurosciences, Universitat de Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain4 aut
7001 a Kühn, Simoneu Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany; Clinic and Policlinic for Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany4 aut
7001 a Boraxbekk, Carl-Johan,d 1980-u Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi,Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC) and Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark4 aut0 (Swepub:umu)olncan02
7001 a Ghisletta, Paolou Faculty of Psychology and Educational Sciences, University of Geneva, Geneva, Switzerland; UniDistance Suisse, Brig, Switzerland; Swiss National Centre of Competence in Research LIVES, University of Geneva, Geneva, Switzerland4 aut
7001 a Madsen, Kathrine Skaku Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Radiography, Department of Technology, University College Copenhagen, Copenhagen, Denmark4 aut
7001 a Baaré, Willliam F. C.u Danish Research Centre for Magnetic Resonance (DRCMR), Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark4 aut
7001 a Zsoldos, Enikőu Department of Psychiatry, University of Oxford, Oxford, United Kingdom; Welcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom4 aut
7001 a Magnussen, Fredriku Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Vidal-Piñeiro, Didacu Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway4 aut
7001 a Penninx, Brendau Amsterdam Neuroscience, Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands4 aut
7001 a Fjell, Anders M.u Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway4 aut
7102 a Center for Lifespan Changes in Brain and Cognition, University of Oslo, Blindern, Oslo, Norway; Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norwayb Umeå centrum för funktionell hjärnavbildning (UFBI)4 org
7730 t Scientific Reportsd : Nature Publishing Groupg 12:1q 12:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-022-17727-6y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1692977/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198903
8564 8u https://doi.org/10.1038/s41598-022-17727-6

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