Sökning: WFRF:(Ekman S.) > Subcortical volumet...
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000 | 06256naa a2201189 4500 | |
001 | oai:gup.ub.gu.se/247964 | |
003 | SwePub | |
008 | 240528s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:134635012 | |
024 | 7 | a https://gup.ub.gu.se/publication/2479642 URI |
024 | 7 | a https://doi.org/10.1038/mp.2015.2272 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1346350122 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hibar, D. P.4 aut |
245 | 1 0 | a Subcortical volumetric abnormalities in bipolar disorder |
264 | c 2016-02-09 | |
264 | 1 | b Springer Science and Business Media LLC,c 2016 |
520 | a Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=-0.232; P=3.50 × 10 -7) and thalamus (d=-0.148; P=4.27 × 10 -3) and enlarged lateral ventricles (d=-0.260; P=3.93 × 10 -5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons. © 2016 Macmillan Publishers Limited, part of Springer Nature. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Westlye, L. T.4 aut |
700 | 1 | a Van Erp, T. G. M.4 aut |
700 | 1 | a Rasmussen, J.4 aut |
700 | 1 | a Leonardo, C. D.4 aut |
700 | 1 | a Faskowitz, J.4 aut |
700 | 1 | a Haukvik, U. K.4 aut |
700 | 1 | a Hartberg, C. B.4 aut |
700 | 1 | a Doan, N. T.4 aut |
700 | 1 | a Agartz, I.u Karolinska Institutet4 aut |
700 | 1 | a Dale, A. M.4 aut |
700 | 1 | a Gruber, O.4 aut |
700 | 1 | a Krämer, B.4 aut |
700 | 1 | a Trost, S.4 aut |
700 | 1 | a Liberg, B.4 aut |
700 | 1 | a Abé, C.u Karolinska Institutet4 aut |
700 | 1 | a Ekman, C. J.u Karolinska Institutet4 aut |
700 | 1 | a Ingvar, M.u Karolinska Institutet4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Fears, S. C.4 aut |
700 | 1 | a Freimer, N. B.4 aut |
700 | 1 | a Bearden, C. E.4 aut |
700 | 1 | a Sprooten, E.4 aut |
700 | 1 | a Glahn, D. C.4 aut |
700 | 1 | a Pearlson, G. D.4 aut |
700 | 1 | a Emsell, L.4 aut |
700 | 1 | a Kenney, J.4 aut |
700 | 1 | a Scanlon, C.4 aut |
700 | 1 | a McDonald, C.4 aut |
700 | 1 | a Cannon, D. M.4 aut |
700 | 1 | a Almeida, J.4 aut |
700 | 1 | a Versace, A.4 aut |
700 | 1 | a Caseras, X.4 aut |
700 | 1 | a Lawrence, N. S.4 aut |
700 | 1 | a Phillips, M. L.4 aut |
700 | 1 | a Dima, D.4 aut |
700 | 1 | a Delvecchio, G.4 aut |
700 | 1 | a Frangou, S.4 aut |
700 | 1 | a Satterthwaite, T. D.4 aut |
700 | 1 | a Wolf, D.4 aut |
700 | 1 | a Houenou, J.4 aut |
700 | 1 | a Henry, C.4 aut |
700 | 1 | a Malt, U. F.4 aut |
700 | 1 | a BØen, E.4 aut |
700 | 1 | a Elvs'shagen, T.4 aut |
700 | 1 | a Young, A. H.4 aut |
700 | 1 | a Lloyd, A. J.4 aut |
700 | 1 | a Goodwin, G. M.4 aut |
700 | 1 | a Mackay, C. E.4 aut |
700 | 1 | a Bourne, C.4 aut |
700 | 1 | a Bilderbeck, A.4 aut |
700 | 1 | a Abramovic, L.4 aut |
700 | 1 | a Boks, M. P.4 aut |
700 | 1 | a Van Haren, N. E. M.4 aut |
700 | 1 | a Ophoff, R. A.4 aut |
700 | 1 | a Kahn, R. S.4 aut |
700 | 1 | a Bauer, M.4 aut |
700 | 1 | a Pfennig, A.4 aut |
700 | 1 | a Alda, M.4 aut |
700 | 1 | a Hajek, T.4 aut |
700 | 1 | a Mwangi, B.4 aut |
700 | 1 | a Soares, J. C.4 aut |
700 | 1 | a Nickson, T.4 aut |
700 | 1 | a Dimitrova, R.4 aut |
700 | 1 | a Sussmann, J. E.4 aut |
700 | 1 | a Hagenaars, S.4 aut |
700 | 1 | a Whalley, H. C.4 aut |
700 | 1 | a McIntosh, A. M.4 aut |
700 | 1 | a Thompson, P. M.4 aut |
700 | 1 | a Andreassen, O. A.4 aut |
700 | 1 | a Elvsashagen, T4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Molecular Psychiatryd : Springer Science and Business Media LLCg 21:12, s. 1710-1716q 21:12<1710-1716x 1359-4184x 1476-5578 |
856 | 4 | u https://www.nature.com/articles/mp2015227.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/247964 |
856 | 4 8 | u https://doi.org/10.1038/mp.2015.227 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134635012 |
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