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Distribution of hos...
Distribution of hospital care among pediatric and young adult Hodgkin lymphoma survivors : A population-based cohort study from Sweden and Denmark
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- Glimelius, Ingrid, 1975- (author)
- Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi,Division of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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- Englund, Annika (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Rostgaard, Klaus (author)
- Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
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- Smedby, Karin E (author)
- Karolinska Institutet
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- Eloranta, Sandra (author)
- Division of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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- de Nully Brown, Peter (author)
- Department of Haematology, Rigshospitalet, Copenhagen, Denmark
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- Johansen, Christoffer (author)
- Danish Cancer Society Research Center, University of Copenhagen, Copenhagen, Denmark
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- Kamper, Peter (author)
- Department of Haematology, Aarhus University Hospital, Aarhus, Denmark
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- Ljungman, Gustaf, 1958- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Hjalgrim, Lisa Lyngsie (author)
- Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Department of Paediatrics and Adolescent Medicine, Rigshospitalet, Copenhagen, Denmark
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- Hjalgrim, Henrik (author)
- Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; Department of Haematology, Rigshospitalet, Copenhagen, Denmark
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(creator_code:org_t)
- 2019-07-02
- 2019
- English.
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In: Cancer Medicine. - : Wiley. - 2045-7634. ; 8:10, s. 4918-4927
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Abstract
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- The burden of late effects among Hodgkin lymphoma (HL) survivors treated according to contemporary protocols remains poorly characterized. We used nation-wide registers to assess number of inpatient bed-days and specialist outpatient visits among 1048 HL-patients (<25 years, diagnosed 1990-2010) and 5175 country-, sex-, and age-matched comparators. We followed them for up to 24 years, with time-dependent assessment of relapse status. International Classification of Diseases (ICD-10) chapter-specific hazard ratios (HRs) were assessed in Cox regression analyses, and nonparametric statistics described patterns of health-care-use. Relative to comparators, relapse-free survivors were at increased risk of infections, diseases of the blood, endocrine, circulatory and respiratory systems, and unspecific symptoms, HRs ranging from 1.86 to 3.05. Relative to comparators, relapsed survivors had at statistically significantly increased risk of diseases reflecting practically all investigated disease-chapters, HRs ranging from 1.60 to 18.7. Among relapse-free survivors, 10% of the patients accounted for 80% of all hospital bed days, and 55% were never hospitalized during follow-up. Among relapsed-survivors, 10% of the patients accounted for 50% of the bed days, and only 24% were never hospitalized during follow-up. In contrast, 10% of the comparators accounted for 90% of hospital bed days and 75% were never hospitalized. These findings challenge the impression of a uniformly distributed long-term morbidity among all HL survivors and emphasize the need for early identification and attention to patients particularly susceptible to late effects, such as relapsed survivors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Hodgkin lymphoma
- hospitalizations
- late adverse effects
- relapse
- survivorship
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Glimelius, Ingri ...
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Englund, Annika
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Rostgaard, Klaus
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Smedby, Karin E
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Eloranta, Sandra
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de Nully Brown, ...
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Johansen, Christ ...
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Kamper, Peter
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Ljungman, Gustaf ...
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Hjalgrim, Lisa L ...
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Hjalgrim, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Medicine
- By the university
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Uppsala University
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Karolinska Institutet