WFRF:(Evans H. C.)
Sökning: WFRF:(Evans H. C.) > (2000-2004) > Average risks of br...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04930naa a2200673 4500 | |
| 001 | oai:lup.lub.lu.se:3936a3e3-1fa0-4196-934b-12960b753fb4 | |
| 003 | SwePub | |
| 008 | 160401s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/3128812 URI |
| 024 | 7 | a https://doi.org/10.1086/3750332 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Antoniou, A4 aut |
| 245 | 1 0 | a Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies |
| 264 | 1 | b Elsevier BV,c 2003 |
| 520 | a Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We pooled pedigree data from 22 studies involving 8,139 index case patients unselected for family history with female (86%) or male (2%) breast cancer or epithelial ovarian cancer (12%), 500 of whom had been found to carry a germline mutation in BRCA1 or BRCA2. Breast and ovarian cancer incidence rates for mutation carriers were estimated using a modified segregation analysis, based on the occurrence of these cancers in the relatives of mutation-carrying index case patients. The average cumulative risks in BRCA1-mutation carriers by age 70 years were 65% (95% confidence interval 44%-78%) for breast cancer and 39% (18%-54%) for ovarian cancer. The corresponding estimates for BRCA2 were 45% (31%-56%) and 11% (2.4%-19%). Relative risks of breast cancer declined significantly with age for BRCA1-mutation carriers ( P trend .0012) but not for BRCA2-mutation carriers. Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age. We found some evidence for a reduction in risk in women from earlier birth cohorts and for variation in risk by mutation position for both genes. The pattern of cancer risks was similar to those found in multiple-case families, but their absolute magnitudes were lower, particularly for BRCA2. The variation in risk by age at diagnosis of index case is consistent with the effects of other genes modifying cancer risk in carriers. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Pharoah, PDP4 aut |
| 700 | 1 | a Narod, S4 aut |
| 700 | 1 | a Risch, HA4 aut |
| 700 | 1 | a Eyfjord, JE4 aut |
| 700 | 1 | a Hopper, JL4 aut |
| 700 | 1 | a Loman, Niklasu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-nlo |
| 700 | 1 | a Olsson, Hu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Johannsson, O4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo |
| 700 | 1 | a Pasini, B4 aut |
| 700 | 1 | a Radice, P4 aut |
| 700 | 1 | a Manoukian, S4 aut |
| 700 | 1 | a Eccles, DM4 aut |
| 700 | 1 | a Tang, N4 aut |
| 700 | 1 | a Olah, E4 aut |
| 700 | 1 | a Anton-Culver, H4 aut |
| 700 | 1 | a Warner, E4 aut |
| 700 | 1 | a Lubinski, J4 aut |
| 700 | 1 | a Gronwald, J4 aut |
| 700 | 1 | a Gorski, B4 aut |
| 700 | 1 | a Tulinius, H4 aut |
| 700 | 1 | a Thorlacius, S4 aut |
| 700 | 1 | a Eerola, H4 aut |
| 700 | 1 | a Nevanlinna, H4 aut |
| 700 | 1 | a Syrjakoski, K4 aut |
| 700 | 1 | a Kallioniemi, OP4 aut |
| 700 | 1 | a Thompson, D4 aut |
| 700 | 1 | a Evans, C4 aut |
| 700 | 1 | a Peto, J4 aut |
| 700 | 1 | a Lalloo, F4 aut |
| 700 | 1 | a Evans, DG4 aut |
| 700 | 1 | a Easton, DF4 aut |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t American Journal of Human Geneticsd : Elsevier BVg 72:5, s. 1117-1130q 72:5<1117-1130x 0002-9297 |
| 856 | 4 | u http://dx.doi.org/10.1086/375033y FULLTEXT |
| 856 | 4 | u http://www.cell.com/article/S0002929707606405/pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/312881 |
| 856 | 4 8 | u https://doi.org/10.1086/375033 |
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