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000 | 13699naa a2204225 4500 | |
001 | oai:gup.ub.gu.se/329974 | |
003 | SwePub | |
008 | 240910s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:153370600 | |
024 | 7 | a https://gup.ub.gu.se/publication/3299742 URI |
024 | 7 | a https://doi.org/10.1038/s41467-023-35974-72 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1533706002 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sliz, E.4 aut |
245 | 1 0 | a Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata |
264 | c 2023-02-01 | |
264 | 1 | b Springer Science and Business Media LLC,c 2023 |
520 | a Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
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700 | 1 | a Kankaanranta, Hannu,d 1967u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xkankh |
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710 | 2 | a Karolinska Institutetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 14:1q 14:1x 2041-1723 |
856 | 4 8 | u https://gup.ub.gu.se/publication/329974 |
856 | 4 8 | u https://doi.org/10.1038/s41467-023-35974-7 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153370600 |
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