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From Cohort to Coho...
From Cohort to Cohort : A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data
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- Sapounidou, Maria (författare)
- Umeå universitet,Kemiska institutionen,Umeå universitet, Sverige,Umeå Univ, Dept Chem, SE-90187 Umeå, Sweden.
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- Andersson, Patrik L. (författare)
- Umeå universitet,Kemiska institutionen,Umeå universitet, Sverige,Umeå Univ, Dept Chem, SE-90187 Umeå, Sweden.
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- Leemans, Michelle (författare)
- UMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France.
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- Fini, Jean-Baptiste (författare)
- UMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France.
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- Demeneix, Barbara (författare)
- UMR 7221, Phyma, CNRS–Muséum National d’Histoire Naturelle, Sorbonne Université, Paris, France,Sorbonne Univ, Museum Natl Hist Nat, UMR 7221, Phyma,CNRS, F-75005 Paris, France.
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- Rüegg, Joëlle (författare)
- Uppsala universitet,Fysiologi och miljötoxikologi
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- Bornehag, Carl-Gustaf, 1957- (författare)
- Karlstads universitet,Institutionen för hälsovetenskaper (from 2013),Icahn School of Medicine at Mount Sinai, USA,Faculty of Health, Science and Technology, Department of Health Sciences, Karlstad University, Karlstad, Sweden; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States,Karlstad Univ, Fac Hlth Sci & Technol, Dept Hlth Sci, SE-65188 Karlstad, Sweden.;Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
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- Gennings, Chris (författare)
- Icahn School of Medicine at Mount Sinai, USA,Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States,Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
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(creator_code:org_t)
- 2023-03-31
- 2023
- Engelska.
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Ingår i: Toxics. - : MDPI. - 2305-6304. ; 11:4
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in children in a Swedish pregnancy cohort. A novel approach was proposed linking this epidemiological association with experimental evidence, where the effect of MIX N on thyroid hormone signaling was assessed using the Xenopus eleuthero-embryonic thyroid assay (XETA OECD TG248). From this experimental data, a point of departure (PoD) was derived based on OECD guidance. Our aim in the current study was to use updated toxicokinetic models to compare exposures of women of reproductive age in the US population to MIX N using a Similar Mixture Approach (SMACH). Based on our findings, 66% of women of reproductive age in the US (roughly 38 million women) had exposures sufficiently similar to MIX N. For this subset, a Similar Mixture Risk Index (SMRIHI) was calculated comparing their exposures to the PoD. Women with SMRIHI > 1 represent 1.1 million women of reproductive age. Older women, Mexican American and other/multi race women were less likely to have high SMRIHI values compared to Non-Hispanic White women. These findings indicate that a reference mixture of chemicals identified in a Swedish cohort—and tested in an experimental model for establishment of (PoDs)—is also of health relevance in a US population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- causal inference
- endocrine-disrupting chemicals
- mixtures risk assessment
- Public Health Science
- Folkhälsovetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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