Sökning: WFRF:(Franke Andre) > Large-scale associa...
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001 | oai:DiVA.org:liu-174837 | |
003 | SwePub | |
008 | 210407s2021 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:su-193301 | |
009 | oai:prod.swepub.kib.ki.se:145699130 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1748372 URI |
024 | 7 | a https://doi.org/10.1038/s41588-020-00763-12 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1933012 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1456991302 URI |
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041 | a engb eng | |
042 | 9 SwePub | |
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100 | 1 | a Kurilshikov, Alexanderu Univ Groningen, Netherlands4 aut |
245 | 1 0 | a Large-scale association analyses identify host factors influencing human gut microbiome composition |
264 | c 2021-01-18 | |
264 | 1 | b Nature Publishing Group,c 2021 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Cancer Research UKCancer Research UK [C18281/A19169] Funding Source: Medline; CIHRCanadian Institutes of Health Research (CIHR) [CMF108031] Funding Source: Medline; Department of HealthEuropean Commission [BRC-1215-20011] Funding Source: Medline; Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC)European Commission [MR/N01183X/1, MC_UU_12013/3, MC_UU_00011/6] Funding Source: Medline; NCATS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Center for Advancing Translational Sciences (NCATS) [UL1 TR002489] Funding Source: Medline; NHGRI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Human Genome Research Institute (NHGRI) [U01 HG004729, U01 HG004446] Funding Source: Medline; NHLBI NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01 HL140976, N01HC65236, N01HC65234, N01HC65237, N01HC65226, N01HC65235, HHSN268201300005C, N01HC65233] Funding Source: Medline; NIDDK NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [R01 DK062370, P30 DK056350, R01 DK092127] Funding Source: Medline; NIMHD NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Minority Health & Health Disparities (NIMHD) [R01 MD011389] Funding Source: Medline; NIMH NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [U24 MH068457, RC2 MH089951, RC2 MH089995] Funding Source: Medline; NINDS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [T32 NS095775] Funding Source: Medline; Wellcome TrustWellcome TrustEuropean Commission [202802/Z/16/Z, 204813/Z/16/Z] Funding Source: Medline | |
520 | a To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data from 18,340 individuals (24 cohorts). Microbial composition showed high variability across cohorts: only 9 of 410 genera were detected in more than 95% of samples. A genome-wide association study of host genetic variation regarding microbial taxa identified 31 loci affecting the microbiome at a genome-wide significant (P < 5 x 10(-8)) threshold. One locus, the lactase (LCT) gene locus, reached study-wide significance (genome-wide association study signal: P = 1.28 x 10(-20)), and it showed an age-dependent association with Bifidobacterium abundance. Other associations were suggestive (1.95 x 10(-10) < P < 5 x 10(-8)) but enriched for taxa showing high heritability and for genes expressed in the intestine and brain. A phenome-wide association study and Mendelian randomization identified enrichment of microbiome trait loci in the metabolic, nutrition and environment domains and suggested the microbiome might have causal effects in ulcerative colitis and rheumatoid arthritis. | |
650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
700 | 1 | a Medina-Gomez, Carolinau Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Bacigalupe, Rodrigou Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
700 | 1 | a Radjabzadeh, Djawadu Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Wang, Junu Katholieke Univ Leuven, Belgium; VIB, Belgium; Chinese Acad Sci, Peoples R China4 aut |
700 | 1 | a Demirkan, Ayseu Univ Groningen, Netherlands; Univ Surrey, England4 aut |
700 | 1 | a Le Roy, Caroline Iu Kings Coll London, England4 aut |
700 | 1 | a Garay, Juan Antonio Raygozau Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut |
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700 | 1 | a Liu, Xingrongu Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden4 aut |
700 | 1 | a Zhernakova, Daria Vu Univ Groningen, Netherlands; ITMO Univ, Russia4 aut |
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700 | 1 | a Turpin, Williamsu Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut |
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700 | 1 | a Lull, Kreeteu Univ Tartu, Estonia4 aut |
700 | 1 | a Barkan, Eladu Weizmann Inst Sci, Israel4 aut |
700 | 1 | a Andreasson, Annau Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet,Copenhagen Univ Hosp, Denmark,Stockholm Univ, Sweden,Univ Bristol, England; Univ Bristol Sch Med, England,Kings Coll London, England; Univ Oxford, England,Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands,Erasmus MC Univ Med Ctr, Netherlands,Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA4 aut0 (Swepub:su)anan6088 |
700 | 1 | a Fornage, Myriamu Univ Texas Hlth Sci Ctr Houston, TX 77030 USA4 aut |
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700 | 1 | a Borisevich, Dmitriiu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Agreus, Larsu Karolinska Institutet,Karolinska Inst, Sweden4 aut |
700 | 1 | a Andreasson, Annau Stockholm Univ, Sweden4 aut |
700 | 1 | a Bang, Corinnau Christian Albrechts Univ Kiel, Germany4 aut |
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700 | 1 | a Bisgaard, Hansu Copenhagen Univ Hosp, Denmark4 aut |
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700 | 1 | a Croitoru, Kennethu Univ Toronto, Canada; Mt Sinai Hosp, Canada4 aut |
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700 | 1 | a van Duijn, Cornelia M.u Erasmus MC Univ Med Ctr, Netherlands; Univ Oxford, England4 aut |
700 | 1 | a Duijts, Liesbethu Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Falony, Gwenu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
700 | 1 | a Fu, Jingyuanu Univ Groningen, Netherlands4 aut |
700 | 1 | a van der Graaf, Adriaanu Univ Groningen, Netherlands4 aut |
700 | 1 | a Hansen, Torbenu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Homuth, Georgu Univ Med Greifswald, Germany4 aut |
700 | 1 | a Hughes, David A.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut |
700 | 1 | a Ijzerman, Richard G.u Amsterdam Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Jackson, Matthew A.u Kings Coll London, England; Univ Oxford, England4 aut |
700 | 1 | a Jaddoe, Vincent W. V.u Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Joossens, Marieu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
700 | 1 | a Jorgensen, Torbenu Univ Copenhagen, Denmark; Univ Copenhagen, Denmark4 aut |
700 | 1 | a Keszthelyi, Danielu Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut |
700 | 1 | a Knight, Robu Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA4 aut |
700 | 1 | a Laakso, Markkuu Univ Eastern Finland, Finland4 aut |
700 | 1 | a Laudes, Matthiasu Univ Hosp Schleswig Holstein, Germany4 aut |
700 | 1 | a Launer, Lenore J.u NIA, MD 20892 USA4 aut |
700 | 1 | a Lieb, Wolfgangu Univ Kiel, Germany4 aut |
700 | 1 | a Lusis, Aldons J.u Univ Calif Los Angeles, CA 90024 USA; Univ Calif Los Angeles, CA USA; Univ Calif Los Angeles, CA 90024 USA4 aut |
700 | 1 | a Masclee, Ad A. M.u Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut |
700 | 1 | a Moll, Henriette A.u Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Mujagic, Zlatanu Maastricht Univ Med Ctr, Netherlands; Maastricht Univ, Netherlands4 aut |
700 | 1 | a Qibin, Qiu Albert Einstein Coll Med, NY 10467 USA4 aut |
700 | 1 | a Rothschild, Daphnau Weizmann Inst Sci, Israel4 aut |
700 | 1 | a Shin, Hocheolu Sungkyunkwan Univ, South Korea; Sungkyunkwan Univ, South Korea4 aut |
700 | 1 | a Sorensen, Soren J.u Univ Copenhagen, Denmark4 aut |
700 | 1 | a Steves, Claire J.u Kings Coll London, England4 aut |
700 | 1 | a Thorsen, Jonathanu Copenhagen Univ Hosp, Denmark4 aut |
700 | 1 | a Timpson, Nicholas J.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut |
700 | 1 | a Tito, Raul Y.u Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
700 | 1 | a Vieira-Silva, Sarau Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
700 | 1 | a Volker, Uweu Univ Med Greifswald, Germany4 aut |
700 | 1 | a Volzke, Henryu Univ Med Greifswald, Germany4 aut |
700 | 1 | a Vosa, Urmou Univ Groningen, Netherlands4 aut |
700 | 1 | a Wade, Kaitlin H.u Univ Bristol, England; Univ Bristol Sch Med, England4 aut |
700 | 1 | a Walter, Susannau Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken4 aut0 (Swepub:liu)suswa35 |
700 | 1 | a Watanabe, Kyokou Vrije Univ Amsterdam, Netherlands4 aut |
700 | 1 | a Weiss, Stefanu Univ Med Greifswald, Germany4 aut |
700 | 1 | a Weiss, Frank U.u Univ Med Greifswald, Germany4 aut |
700 | 1 | a Weissbrod, Omeru Harvard Univ, MA 02115 USA4 aut |
700 | 1 | a Westra, Harm-Janu Univ Groningen, Netherlands4 aut |
700 | 1 | a Willemsen, Gonnekeu Vrije Univ, Netherlands4 aut |
700 | 1 | a Payami, Haydehu Univ Alabama Birmingham, AL 35294 USA4 aut |
700 | 1 | a Jonkers, Daisy M. A. E.u Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain4 aut |
700 | 1 | a Vasquez, Alejandro Ariasu Univ Texas Hlth Sci Ctr Houston, TX USA; Radboudumc, Netherlands; Radboudumc, Netherlands4 aut |
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700 | 1 | a Meyer, Katie A.u Univ N Carolina, NC USA; Univ North Carolina Chapel Hill, NC USA4 aut |
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700 | 1 | a Segal, Eranu Weizmann Inst Sci, Israel4 aut |
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700 | 1 | a Rivadeneira, Fernandou Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Franke, Andreu Christian Albrechts Univ Kiel, Germany4 aut |
700 | 1 | a Lerch, Markus M.u Univ Med Greifswald, Germany4 aut |
700 | 1 | a Franke, Ludeu Univ Groningen, Netherlands4 aut |
700 | 1 | a Sanna, Serenau Univ Groningen, Netherlands; CNR, Italy4 aut |
700 | 1 | a DAmato, Maurou Karolinska Inst, Sweden; Karolinska Inst, Sweden; Monash Univ, Australia; Biodonostia Hlth Res Inst, Spain; Basque Sci Fdn, Spain4 aut |
700 | 1 | a Pedersen, Olufu Univ Copenhagen, Denmark4 aut |
700 | 1 | a Paterson, Andrew D.u Hosp Sick Children Res Inst, Canada4 aut |
700 | 1 | a Kraaij, Robertu Erasmus MC Univ Med Ctr, Netherlands4 aut |
700 | 1 | a Raes, Jeroenu Katholieke Univ Leuven, Belgium; VIB, Belgium4 aut |
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710 | 2 | a Univ Groningen, Netherlandsb Erasmus MC Univ Med Ctr, Netherlands; Erasmus MC Univ Med Ctr, Netherlands4 org |
773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 53:2, s. 156-165q 53:2<156-165x 1061-4036x 1546-1718 |
856 | 4 | u https://pure.rug.nl/ws/files/159312822/s41588_020_00763_1.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-174837 |
856 | 4 8 | u https://doi.org/10.1038/s41588-020-00763-1 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-193301 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145699130 |
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