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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005871naa a2200637 4500
001oai:lup.lub.lu.se:0032fda5-bcaa-43c6-b56c-06f17af09aac
003SwePub
008210501s2021 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/0032fda5-bcaa-43c6-b56c-06f17af09aac2 URI
0247 a https://doi.org/10.1002/ijc.336122 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Mayén, Ana-Luciau International Agency for Research on Cancer, World Health Organization4 aut
2451 0a Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers : a multinational cohort study
264 c 2021-05-06
264 1b Wiley,c 2021
300 a 11 s.
520 a Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their pro-inflammatory and pro-oxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer aetiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n=450,111). Dietary intake of three AGEs, Nε -[carboxymethyl]lysine (CML), Nε -[1-carboxyethyl]lysine (CEL), and Nδ -[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder, and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer, and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with risk of HCC (per 1 standard deviation [SD] increment, HR-CML =0.87, 95% CI: 0.76 to 0.99, HR-CEL =0.84, 95% CI: 0.74 to 0.96, and HR-MH-G1 = 0.84, 95% CI: 0.74 to 0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-CML =1.28, 95% CI: 1.05 to 1.56, HR-CEL =1.17; 95% CI: 0.96 to 1.40, HR-MH-G1 =1.27, 95% CI: 1.06 to 1.54). No associations were observed for cancers of the intra- and extra-hepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Aglago, Elom Ku International Agency for Research on Cancer, World Health Organization4 aut
7001 a Knaze, Viktoriau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Cordova, Reynaldau Webster Vienna Private University4 aut
7001 a Schalkwijk, Casper Gu Maastricht University Medical Centre4 aut
7001 a Wagner, Karl-Heinzu Webster Vienna Private University4 aut
7001 a Aleksandrova, Krasimirau German Institute of Human Nutrition4 aut
7001 a Fedirko, Veronikau Emory University4 aut
7001 a Keski-Rahkonen, Pekkau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Leitzmann, Michael Fu University Hospital Regensburg4 aut
7001 a Katzke, Verenau German Cancer Research Centre4 aut
7001 a Srour, Bernardu German Cancer Research Centre4 aut
7001 a Schulze, Matthias Bu German Institute of Human Nutrition4 aut
7001 a Masala, Giovannau Beatson Institute for Cancer Research4 aut
7001 a Krogh, Vittorio4 aut
7001 a Panico, Salvatoreu University of Naples Federico II4 aut
7001 a Tumino, Rosario4 aut
7001 a Bueno-de-Mesquita, Basu National Institute for Public Health and the Environment (RIVM)4 aut
7001 a Brustad, Magrittu UiT The Arctic University of Norway, Tromsø4 aut
7001 a Agudo, Antoniou Catalan Institute of Oncology-Girona4 aut
7001 a Chirlaque López, María Doloresu Shanghai Cancer Institute4 aut
7001 a Amiano, Pilaru Biodonostia Health Research Institute4 aut
7001 a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh
7001 a Ramne, Stinau Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)st1854ra
7001 a Aune, Dagfinnu Imperial College London4 aut
7001 a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization4 aut
7001 a Jenab, Mazdau International Agency for Research on Cancer, World Health Organization4 aut
7001 a Freisling, Heinzu International Agency for Research on Cancer, World Health Organization4 aut
7102 a International Agency for Research on Cancer, World Health Organizationb Webster Vienna Private University4 org
7730 t International Journal of Cancerd : Wileyg 149:4, s. 854-864q 149:4<854-864x 0020-7136x 1097-0215
8564 u http://dx.doi.org/10.1002/ijc.33612x freey FULLTEXT
8564 u https://doi.org/10.1002/ijc.33612
8564 8u https://lup.lub.lu.se/record/0032fda5-bcaa-43c6-b56c-06f17af09aac
8564 8u https://doi.org/10.1002/ijc.33612

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