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- Björkstrand, JohannesUppsala universitet,Institutionen för psykologi,Uppsala Universitet (author)
Disrupting Reconsolidation Attenuates Long-Term Fear Memory in the Human Amygdala and Facilitates Approach Behavior
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- Elsevier BV,2016
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-302737
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302737URI
- https://doi.org/10.1016/j.cub.2016.08.022DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38881URI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134394151URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Memories become labile and malleable to modification when recalled [1]. Fear-conditioning experiments in both rodents and humans indicate that amygdala-localized short-term fear memories can be attenuated by disruption of their reconsolidation with extinction training soon after memory activation [2-7]. However, this may not be true for natural long-term fears. Studies in rodents indicate that although it is possible to disrupt the reconsolidation of older memories [8-11], they appear to be more resistant [1, 3, 9, 12, 13]. In humans, 1-week-old conditioned fear memories have been attenuated by behaviorally induced disruption of reconsolidation [14], but it remains to be seen whether this is possible for naturally occurring long-term fears and whether the underlying neural mechanisms are similar to those found in experimental fear-conditioning paradigms. Using functional brain imaging in individuals with a lifelong fear of spiders, we show that fear memory activation followed by repeated exposure to feared cues after 10 min, which disrupts reconsolidation, attenuates activity in the basolateral amygdala at re-exposure 24 hr later. In contrast, repeated exposure 6 hr after fear memory activation, which allows for reconsolidation, did not attenuate amygdala activity. Disrupted, but not undisrupted, reconsolidation facilitated approach behavior to feared cues, and approach behavior was inversely related to amygdala activity during re-exposure. We conclude that memory activation immediately preceding exposure attenuates the neural and behavioral expression of decades-old fear memories and that, similar to experimentally induced fear memories, the basolateral amygdala is crucially involved in this process.
Subject headings and genre
- SAMHÄLLSVETENSKAP Psykologi hsv//swe
- SOCIAL SCIENCES Psychology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
Added entries (persons, corporate bodies, meetings, titles ...)
- Ågren, ThomasUppsala universitet,Institutionen för psykologi,Uppsala Universitet(Swepub:uu)thoag299 (author)
- Åhs, FredrikKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden,Uppsala Universitet; Karolinska Institutet(Swepub:miun)freahs (author)
- Frick, AndreasUppsala universitet,Institutionen för psykologi,Uppsala Universitet(Swepub:uu)andfr548 (author)
- Larsson, Elna-MarieUppsala universitet,Radiologi,Uppsala Universitet(Swepub:uu)elnla305 (author)
- Hjorth, OlofUppsala universitet,Institutionen för psykologi,Uppsala Universitet(Swepub:uu)olohj176 (author)
- Furmark, TomasUppsala universitet,Institutionen för psykologi,Uppsala Universitet(Swepub:uu)tomafurm (author)
- Fredrikson, MatsKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden,Uppsala Universitet; Karolinska Institutet(Swepub:uu)matsfred (author)
- Uppsala universitetInstitutionen för psykologi (creator_code:org_t)
Related titles
- In:Current Biology: Elsevier BV26:19, s. 2690-950960-98221879-0445
Internet link
- http://www.cell.com/article/S0960982216309344/pdf
- https://doi.org/10.1016/j.cub.2016.08.022Fulltext
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-302737
- https://doi.org/10.1016/j.cub.2016.08.022
- https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38881
- http://kipublications.ki.se/Default.aspx?queryparsed=id:134394151
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