Sökning: WFRF:(GABRIELLI A) > (1995-1999) > Differential humora...
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000 | 03206naa a2200361 4500 | |
001 | oai:prod.swepub.kib.ki.se:1936033 | |
003 | SwePub | |
008 | 240811s1996 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19360332 URI |
024 | 7 | a https://doi.org/10.1046/j.1365-2249.1996.d01-720.x2 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gabrielli, A4 aut |
245 | 1 0 | a Differential humoral immune response against hepatitis C virus antigenic synthetic peptides in infected patients with and without mixed cryoglobulinaemia |
264 | c 2003-10-29 | |
264 | 1 | b Oxford University Press (OUP),c 1996 |
520 | a In this study we have evaluated the prevalence of antibodies against core region peptides (residues 1–28, 21–38 and 51–68), the envelope 1, the non-structural (NS) 4 and 5 proteins of hepatitis C virus (HCV) in sera from 65 chronically HCV-infected patients, 47 with mixed cryoglobulinaemia (MC+) and 18 without (MC−). The major binding sites were located within the core region. Regions 1–28 and 51–68 were recognized by a similar proportion of MC+ and MC− patients, while peptide 21–38 was less frequently detected by samples from MC+ patients (65.5% versus 100%; P=0.011). The patterns of the reactions showed a minimum of three binding sites: one, located within region 51–68, was shared by both groups; a second determinant was identified at residues 1–21 for MC+ patients and at residues 28–38 for MC− patients; a third, not exactly localized, lay between residues 1 and 38. Recognition of NS5 peptides was not significantly different between MC+ and MC− patients, but while the former mostly reacted either with peptide 1 (residues 2294–2309) (five of 15 sera) or with peptide 2 (residues 2304–2319) (nine of 15 sera), the latter group showed a more scattered reaction. Antibodies to HCV peptides prevalently belonged to IgG1 subclass. However, whereas IgG1 antibodies against peptide 21–38 and peptide 1 of NS5 were more frequently found in MC− rather than in MC+ patients (100% versus 63.8%, P=0.003, and 22.2% versus 4.2%, P=0.025, respectively), IgG3 antibodies against region 1–28 were more frequent in MC+ patients (53.19% versus 16.6%, P=0.0078). Overall, the data suggest that a differential humoral immune response to HCV antigens occurs in patients with and without cryoglobulinaemia. | |
700 | 1 | a Zhang, ZX4 aut |
700 | 1 | a Cherubini, G4 aut |
700 | 1 | a Candela, M4 aut |
700 | 1 | a Savoldi, S4 aut |
700 | 1 | a Manzin, A4 aut |
700 | 1 | a Clementi, M4 aut |
700 | 1 | a Amoroso, A4 aut |
700 | 1 | a Sallberg, Mu Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Clinical and experimental immunologyd : Oxford University Press (OUP)g 105:1, s. 59-64q 105:1<59-64x 0009-9104x 1365-2249 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2249.1996.d01-720.x |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1936033 |
856 | 4 8 | u https://doi.org/10.1046/j.1365-2249.1996.d01-720.x |
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