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Different expressio...
Different expression levels of glycans on leukemic cells-a novel screening method with molecularly imprinted polymers (MIP) targeting sialic acid
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- El-Schich, Zahra (författare)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden
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- Abdullah, Mohammad (författare)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden
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- Shinde, Sudhirkumar (författare)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden
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- Dizeyi, Nishtman (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,Department of Translational Medicine, Lund University, Malmö, Sweden
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- Rosén, Anders (författare)
- Linköpings universitet,Linköping University,Avdelningen för cellbiologi,Medicinska fakulteten
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- Sellergren, Börje (författare)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden
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- Gjörloff Wingren, Anette (författare)
- Malmö University,Malmö högskola,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden
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(creator_code:org_t)
- 2016-07-31
- 2016
- Engelska.
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Ingår i: Tumor Biology. - : Springer. - 1010-4283 .- 1423-0380. ; 10:37, s. 13763-13768
- Relaterad länk:
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https://www.ncbi.nlm...
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https://link.springe...
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Sialic acid (SA) is normally expressed on the cell membranes and is located at the terminal position of the sugar chains. SA plays an important role for regulation of the innate immunity, function as markers of the cells and can be recognized by a variety of receptors. Interestingly, the level of SA expression is increased on metastatic cancer cells. The availability of specific antibodies against SA is limited and, therefore, biomarker tools for detection of SA are lacking. We have recently presented a novel method for specific fluorescence labeling of SA molecular imprinted polymers (MIP). Here, we have performed an extended screening of SA expression by using SA-MIP and included four different chronic lymphocytic leukemia (CLL) cell lines, conveniently analyzed by flow cytometry and fluorescence microscopy. SA expression was detected in four cell lines at different levels, and the SA expression were verified with lectin-FITC. These results show that SA-MIP can be used as a plastic antibody for detection of SA using both flow cytometry and fluorescence microscopy. We suggest that SA-MIP can be used for screening of different tumor cells of various stages, including CLL cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Chronic lymphocytic leukemia
- Lectin
- Molecular imprinting polymers
- Sialic acid
- Chronic lymphocytic leukemia
- Lectin
- Molecular imprinting polymers
- Sialic acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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