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C-12 vs C-3 substit...
C-12 vs C-3 substituted bile salts : An example of the effects of substituent position and orientation on the self-assembly of steroid surfactant isomers
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- Cautela, Jacopo (författare)
- Sapienza University of Rome
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- Severoni, Emilia (författare)
- Sapienza University of Rome
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- Redondo-Gómez, Carlos (författare)
- University of Costa Rica
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- di Gregorio, Maria Chiara (författare)
- Sapienza University of Rome
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- Del Giudice, Alessandra (författare)
- Sapienza University of Rome
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- Sennato, Simona (författare)
- Sapienza University of Rome
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- Angelini, Roberta (författare)
- Sapienza University of Rome
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- D'Abramo, Marco (författare)
- Sapienza University of Rome
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- Schillén, Karin (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Galantini, Luciano (författare)
- Sapienza University of Rome
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Colloids and Surfaces B: Biointerfaces. - : Elsevier BV. - 0927-7765. ; 185
- Relaterad länk:
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http://dx.doi.org/10...
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https://iris.uniroma...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biomolecule derivatives are transversally used in nanotechnology. Deciphering their aggregation behavior is a crucial issue for the rational design of functional materials. To this end, it is necessary to build libraries of selectively functionalized analogues and infer general rules. In this work we enrich the highly applicative oriented collection of steroid derivatives, by reporting a rare example of C-12 selectively modified bile salt. While nature often exploits such position to encode functions, it is unusual and not trivial to prepare similar analogues in the laboratory. The introduction of a tert-butyl phenyl residue at C-12 provided a molecule with a self-assembly that remarkably switched from rigid pole-like structures to twisted ribbons at a biologically relevant critical temperature (∼25 °C). The system was characterized by microscopy and spectroscopy techniques and compared with the C-3 functionalized analogue. The twisted ribbons generate samples with a gel texture and a viscoelastic response. The parallel analysis of the two systems suggested that the observed thermoresponsive self-assemblies occur at similar critical temperatures and are probably dictated by the nature of the substituent, but involve aggregates with different structures depending on position and orientation of the substituent. This study highlights the self-assembly properties of two appealing thermoresponsive systems. Moreover, it adds fundamental insights hereto missing in the investigations of the relation between self-assembly and structure of synthetic steroids, which are valuable for the rational design of steroidal amphiphiles.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Bile acid
- Hydrogel
- Steroid derivatives
- Thermoresponsive self-assembly
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Cautela, Jacopo
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Severoni, Emilia
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Redondo-Gómez, C ...
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di Gregorio, Mar ...
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Del Giudice, Ale ...
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Sennato, Simona
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visa fler...
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Angelini, Robert ...
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D'Abramo, Marco
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Schillén, Karin
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Galantini, Lucia ...
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Materialkemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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Colloids and Sur ...
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Lunds universitet