WFRF:(Gomez Gregorio)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02408naa a2200385 4500 | |
| 001 | oai:DiVA.org:uu-129106 | |
| 003 | SwePub | |
| 008 | 100805s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1291062 URI |
| 024 | 7 | a https://doi.org/10.1016/j.immuni.2009.02.0082 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Charles, Nicolas4 aut |
| 245 | 1 0 | a Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation |
| 264 | 1 | b Elsevier BV,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a T helper 1 (Th1)-Th2 cell balance is key to host defense and its dysregulation has pathophysiological consequences. Basophils are important in Th2 cell differentiation. However, the factors controlling the onset and extent of basophil-mediated Th2 cell differentiation are unknown. Here, we demonstrate that Lyn kinase dampened basophil expression of the transcription factor GATA-3 and the initiation and extent of Th2 cell differentiation. Lyn-deficient mice had a marked basophilia, a constitutive Th2 cell skewing that was exacerbated upon in vivo challenge of basophils, produced antibodies to a normally inert antigen, and failed to appropriately respond to a Th1 cell-inducing pathogen. The Th2 cell skewing was dependent on basophils, immunoglobulin E, and interleukin-4, but was independent of mast cells. Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Watford, T4 aut |
| 700 | 1 | a Ramos, L4 aut |
| 700 | 1 | a Hellman, Larsu Uppsala universitet,Institutionen för cell- och molekylärbiologi4 aut0 (Swepub:uu)larshell |
| 700 | 1 | a Oettgen, C4 aut |
| 700 | 1 | a Gomez, Gregorio4 aut |
| 700 | 1 | a Ryan, J4 aut |
| 700 | 1 | a O'Shea, J4 aut |
| 700 | 1 | a Rivera, Juan4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för cell- och molekylärbiologi4 org |
| 773 | 0 | t Immunityd : Elsevier BVg 30:4, s. 533-543q 30:4<533-543x 1074-7613x 1097-4180 |
| 856 | 4 | u http://www.cell.com/article/S1074761309001447/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129106 |
| 856 | 4 8 | u https://doi.org/10.1016/j.immuni.2009.02.008 |
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