Serum neopterin levels in relation to mild and severe COVID-19

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Fältnamn	Indikatorer	Metadata
000		05429naa a2200541 4500
001		oai:research.chalmers.se:88be362a-3942-4a7e-a139-f407c3d64f43
003		SwePub
008		201220s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:gup.ub.gu.se/299189
024	7	a https://doi.org/10.1186/s12879-020-05671-72 DOI
024	7	a https://research.chalmers.se/publication/5210812 URI
024	7	a https://gup.ub.gu.se/publication/2991892 URI
040		a (SwePub)cthd (SwePub)gu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Robertson, Josefinau Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xrobej
245	1 0	a Serum neopterin levels in relation to mild and severe COVID-19
264		c 2020-12-10
264	1	b Springer Science and Business Media LLC,c 2020
338		a electronic2 rdacarrier
520		a Background: The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, is rapidly spreading worldwide. There is limited information about prognostic markers that could help clinicians to identify COVID-19 patients with a poor prognosis. Serum levels of the immune activation marker neopterin has shown to be of prognostic value in patients with SARS. The aim of this study was to investigate whether serum neopterin is associated with the severity of COVID-19. Methods: We included 34 patients with confirmed COVID-19 between March 3 and March 30, 2020. Fifteen patients had mild disease and did not require hospitalization, whereas 19 patients developed severe COVID-19 requiring intensive care. Concentrations of serum neopterin, tryptophan, and kynurenine were measured at and repeatedly after inclusion. Results: We found a more than two-fold higher mean concentration of neopterin in severely ill patients (mean value 42.0 nmol/L (SD 18.2)) compared to patients with mild symptoms (16.9 nmol/L (SD 11.0)). All of the severe cases had elevated neopterin concentrations (> 9.1 nmol/L) at the initial sampling with values ranging from 17.2 to 86.7 nmol/L. In comparison, 10 of 15 patients with mild disease had neopterin levels above 9.1 nmol/L, with concentrations in the range from 4.9 to 31.6 nmol/L. Neopterin levels gradually decreased during the course of COVID-19, but severe cases maintained elevated levels for a longer period. Moreover, lower levels of tryptophan and higher levels of kynurenine, indicating an increased tryptophan catabolism, were seen in the group with severe cases. Conclusions: In conclusion, we found that serum neopterin levels are associated with the severity of COVID-19. Our findings suggest that neopterin could be used as a prognostic marker, but further studies are needed to elucidate how it can be used in the clinic.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
653		a Neopterin
653		a Tryptophan
653		a COVID-19
653		a Kynurenine
653		a Prognostic markers
700	1	a Gostner, Johanna M.u Medizinische Universität Innsbruck,Medical University of Innsbruck4 aut
700	1	a Nilsson, Staffan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences4 aut0 (Swepub:gu)xnista
700	1	a Andersson, Lars-Magnus,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xalarh
700	1	a Fuchs, D.u Medizinische Universität Innsbruck,Medical University of Innsbruck4 aut
700	1	a Gisslén, Magnus,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine4 aut0 (Swepub:gu)xgissm
710	2	a Göteborgs universitetb Institutionen för biomedicin, avdelningen för infektionssjukdomar4 org
773	0	t BMC Infectious Diseasesd : Springer Science and Business Media LLCg 20:1q 20:1x 1471-2334
856	4	u https://research.chalmers.se/publication/521081/file/521081_Fulltext.pdfx primaryx freey FULLTEXT
856	4	u https://bmcinfectdis.biomedcentral.com/track/pdf/10.1186/s12879-020-05671-7
856	4 8	u https://doi.org/10.1186/s12879-020-05671-7
856	4 8	u https://research.chalmers.se/publication/521081
856	4 8	u https://gup.ub.gu.se/publication/299189

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