Sökning: WFRF:(Höglund P.)
> (1985-1989) >
Liquid chromatograp...
Liquid chromatographic determination of diltiazem and its metabolites using trans isomers as internal standards, with dynamic modification of the solid phase by addition of an amine to the mobile phase
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- Höglund, P (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Proteasinhibitorforskning,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Clinical studies in CKD,Protease Inhibitor Research
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Nilsson, L G (författare)
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(creator_code:org_t)
- 1987
- 1987
- Engelska.
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Ingår i: Journal of Chromatography. B. - 0378-4347. ; 414:1, s. 20-109
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- A selective and sensitive reversed-phase high-performance liquid chromatographic method for simultaneous analysis of diltiazem and its five metabolites known to occur in man is presented. Different C18 columns are compared. The influences of organic co-solvent, pH, ionic strength and the addition of various amines are studied. The use of trans-diltiazem as internal standard is advocated. UV detection at 237 nm is used for plasma analyses. The possibilities of electrochemical detection are also discussed. Before solvent extraction, plasma samples are saturated with sodium chloride and made alkaline. Triethylamine is also added. The use of the method in pharmacokinetic applications is exemplified.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Amines
- Biotransformation
- Chromatography, High Pressure Liquid
- Diltiazem
- Humans
- Kinetics
- Spectrophotometry, Ultraviolet
- Stereoisomerism
- Journal Article
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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