GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

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Fältnamn	Indikatorer	Metadata
000		08053naa a2201717 4500
001		oai:DiVA.org:umu-164653
003		SwePub
008		191025s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:141795579
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1646532 URI
024	7	a https://doi.org/10.1176/appi.ajp.2019.180809572 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1417955792 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mullins, Niamh4 aut
245	1 0	a GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores
264	1	b American Psychiatric Association Publishing,c 2019
338		a print2 rdacarrier
520		a Objective: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium.Methods: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders.Results: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R2=0.25%), bipolar disorder (R2=0.24%), and schizophrenia (R2=0.40%).Conclusions: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Bigdeli, Tim B.4 aut
700	1	a Borglum, Anders D.4 aut
700	1	a Coleman, Jonathan R., I4 aut
700	1	a Demontis, Ditte4 aut
700	1	a Mehta, Divya4 aut
700	1	a Power, Robert A.4 aut
700	1	a Ripke, Stephan4 aut
700	1	a Stahl, Eli A.4 aut
700	1	a Starnawska, Anna4 aut
700	1	a Anjorin, Adebayo4 aut
700	1	a Corvin, Aiden4 aut
700	1	a Sanders, Alan R.4 aut
700	1	a Forstner, Andreas J.4 aut
700	1	a Reif, Andreas4 aut
700	1	a Koller, Anna C.4 aut
700	1	a Swiatkowska, Beata4 aut
700	1	a Baune, Bernhard T.4 aut
700	1	a Mueller-Myhsok, Bertram4 aut
700	1	a Penninx, Brenda W. J. H.4 aut
700	1	a Pato, Carlos4 aut
700	1	a Zai, Clement4 aut
700	1	a Rujescu, Dan4 aut
700	1	a Hougaard, David M.4 aut
700	1	a Quested, Digby4 aut
700	1	a Levinson, Douglas F.4 aut
700	1	a Binder, Elisabeth B.4 aut
700	1	a Byrne, Enda M.4 aut
700	1	a Agerbo, Esben4 aut
700	1	a Streit, Fabian4 aut
700	1	a Mayoral, Fermin4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Breen, Gerome4 aut
700	1	a Marken, Gunnar4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Rouleau, Guy A.4 aut
700	1	a Grabe, Hans J.4 aut
700	1	a Voelzke, Henry4 aut
700	1	a Jones, Ian4 aut
700	1	a Giegling, Ina4 aut
700	1	a Agartz, Ingridu Karolinska Institutet4 aut
700	1	a Melle, Ingrid4 aut
700	1	a Lawrence, Jacob4 aut
700	1	a Walters, James T. R.4 aut
700	1	a Strohmaier, Jana4 aut
700	1	a Shi, Jianxin4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Biernacka, Joanna M.4 aut
700	1	a Vincent, John B.4 aut
700	1	a Kelsoe, John4 aut
700	1	a Strauss, John S.4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Pimm, Jonathan4 aut
700	1	a Smoller, Jordan W.4 aut
700	1	a Guzman-Parra, Jose4 aut
700	1	a Berger, Klaus4 aut
700	1	a Scott, Laura J.4 aut
700	1	a Jones, Lisa A.4 aut
700	1	a Azevedo, M. Helena4 aut
700	1	a Trzaskowski, Maciej4 aut
700	1	a Kogevinas, Manolis4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Boks, Marco4 aut
700	1	a Ising, Marcus4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Hamshere, Marian L.4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Frye, Mark4 aut
700	1	a Noethen, Markus M.4 aut
700	1	a Alda, Martin4 aut
700	1	a Preisig, Martin4 aut
700	1	a Nordentoft, Merete4 aut
700	1	a Boehnke, Michael4 aut
700	1	a O'Donovan, Michael C.4 aut
700	1	a Owen, Michael J.4 aut
700	1	a Pato, Michele T.4 aut
700	1	a Renteria, Miguel E.4 aut
700	1	a Budde, Monika4 aut
700	1	a Weissman, Myrna M.4 aut
700	1	a Wray, Naomi R.4 aut
700	1	a Bass, Nicholas4 aut
700	1	a Craddock, Nicholas4 aut
700	1	a Smeland, Olav B.4 aut
700	1	a Andreassen, Ole A.4 aut
700	1	a Mors, Ole4 aut
700	1	a Gejman, Pablo, V4 aut
700	1	a Sklar, Pamela4 aut
700	1	a McGrath, Patrick4 aut
700	1	a Hoffmann, Per4 aut
700	1	a McGuffin, Peter4 aut
700	1	a Lee, Phil H.4 aut
700	1	a Mortensen, Preben Bo4 aut
700	1	a Kahn, Rene S.4 aut
700	1	a Ophoff, Roel A.4 aut
700	1	a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001
700	1	a Van Der Auwera, Sandra4 aut
700	1	a Djurovic, Srdjan4 aut
700	1	a Klaiber, Stefan4 aut
700	1	a Heilmann-Heimbach, Stefanie4 aut
700	1	a Jamain, Stephane4 aut
700	1	a Hamilton, Steven P.4 aut
700	1	a McElroy, Susan L.4 aut
700	1	a Lucae, Susanne4 aut
700	1	a Cichon, Sven4 aut
700	1	a Schulze, Thomas G.4 aut
700	1	a Hansen, Thomas4 aut
700	1	a Werge, Thomas4 aut
700	1	a Air, Tracy M.4 aut
700	1	a Nimgaonkar, Vishwajit4 aut
700	1	a Appadurai, Vivek4 aut
700	1	a Cahn, Wiepke4 aut
700	1	a Milaneschi, Yuri4 aut
700	1	a Fanous, Ayman H.4 aut
700	1	a Kendler, Kenneth S.4 aut
700	1	a McQuillin, Andrew4 aut
700	1	a Lewis, Cathryn M.4 aut
710	2	a Karolinska Institutetb Psykiatri4 org
773	0	t American Journal of Psychiatryd : American Psychiatric Association Publishingg 176:8, s. 651-660q 176:8<651-660x 0002-953Xx 1535-7228
856	4	u https://ajp.psychiatryonline.org/doi/pdf/10.1176/appi.ajp.2019.18080957
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164653
856	4 8	u https://doi.org/10.1176/appi.ajp.2019.18080957
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141795579

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Av författaren/redakt...: Mullins, Niamh; Bigdeli, Tim B.; Borglum, Anders ...; Coleman, Jonatha ...; Demontis, Ditte; Mehta, Divya; visa fler...; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andrea ...; Reif, Andreas; Koller, Anna C.; Swiatkowska, Bea ...; Baune, Bernhard ...; Mueller-Myhsok, ...; Penninx, Brenda ...; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David ...; Quested, Digby; Levinson, Dougla ...; Binder, Elisabet ...; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Fran ...; Breen, Gerome; Marken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Voelzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T ...; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joann ...; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolan ...; Pimm, Jonathan; Smoller, Jordan ...; Guzman-Parra, Jo ...; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Hele ...; Trzaskowski, Mac ...; Kogevinas, Manol ...; Rietschel, Marce ...; Boks, Marco; Ising, Marcus; Grigoroiu-Serban ...; Hamshere, Marian ...; Leboyer, Marion; Frye, Mark; Noethen, Markus ...; Alda, Martin; Preisig, Martin; Nordentoft, Mere ...; Boehnke, Michael; O'Donovan, Micha ...; Owen, Michael J.; Pato, Michele T.; Renteria, Miguel ...; Budde, Monika; Weissman, Myrna ...; Wray, Naomi R.; Bass, Nicholas; Craddock, Nichol ...; Smeland, Olav B.; Andreassen, Ole ...; Mors, Ole; Gejman, Pablo, V; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Prebe ...; Kahn, Rene S.; Ophoff, Roel A.; Adolfsson, Rolf; Van Der Auwera, ...; Djurovic, Srdjan; Klaiber, Stefan; Heilmann-Heimbac ...; Jamain, Stephane; Hamilton, Steven ...; McElroy, Susan L ...; Lucae, Susanne; Cichon, Sven; Schulze, Thomas ...; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vish ...; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth ...; McQuillin, Andre ...; Lewis, Cathryn M ...; visa färre...

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