Peripheral Lipopolysaccharide Administration Induces Cytokine mRNA Expression in the Viscera and Brain of Fever-Refractory Mice Lacking Microsomal Prostaglandin E Synthase-1

Nilsberth, Camilla (författare): Linköpings universitet,Cellbiologi,Hälsouniversitetet

Hamzic, Namik (författare): Linköpings universitet,Cellbiologi,Hälsouniversitetet

Norell, M. (författare): Linköpings universitet,Cellbiologi,Hälsouniversitetet

Blomqvist, Anders (författare): Linköpings universitet,Cellbiologi,Hälsouniversitetet

(creator_code:org_t)

Wiley, 2009
2009
Engelska.
Ingår i: Journal of neuroendocrinology (Print). - : Wiley. - 0953-8194 .- 1365-2826. ; 21:8, s. 715-721

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Abstract Ämnesord

Stäng

We examined the expression of interleukin (IL)-1 beta, IL-6 and tumour necrosis factor (TNF) alpha in mice lacking microsomal prostaglandin E synthase-1 (mPGES-1), which neither produce prostaglandin E-2, nor mount a febrile response upon immune challenge. Intraperitoneal lipopolysaccharide (LPS) injection resulted in a strongly induced expression of all three cytokines in the brain and viscera, similar to wild-type animals. Several brain regions additionally showed modest induction of receptors for these cytokines in both genotypes. Telemetric recordings of body temperature showed that the mPGES-1 deficient mice remained afebrile upon LPS challenge, in contrast to the prominent fever displayed by the wild-type mice. These data demonstrate that LPS-induced cytokine expression occurs independently of prostaglandin E-2, and imply that endogenously expressed IL-1 beta, IL-6, and TNF alpha are not pyrogenic per se, supporting the role of prostaglandin E-2 as the final and obligatory mediator of LPS-induced fever.

Av författaren/redakt...: Nilsberth, Camil ...; Hamzic, Namik; Norell, M.; Blomqvist, Ander ...

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