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Factors Associated ...
Factors Associated With Circulating Sex Hormones in Men
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- Marriott, Ross J. (författare)
- University of Western Australia, Perth
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- Murray, Kevin (författare)
- University of Western Australia, Perth
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- Adams, Robert J. (författare)
- Flinders University
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- Antonio, Leen (författare)
- Catholic University of Leuven
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- Ballantyne, Christie M. (författare)
- Baylor College of Medicine
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- Bauer, Douglas C. (författare)
- University of California, San Francisco
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- Bhasin, Shalender (författare)
- Harvard Medical School
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- Biggs, Mary L. (författare)
- University of Washington
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- Cawthon, Peggy M. (författare)
- California Pacific Medical Center
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- Couper, David J. (författare)
- University of North Carolina
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- Dobs, Adrian S. (författare)
- Johns Hopkins University School of Medicine
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Flicker, Leon (författare)
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- Handelsman, David J. (författare)
- University of Sydney
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Hankey, Graeme J. (författare)
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- Hannemann, Anke (författare)
- University Hospital Greifswald
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- Haring, Robin (författare)
- Monash University
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- Hsu, Benjumin (författare)
- University of New South Wales
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- Karlsson, Magnus (författare)
- Lund University,Lunds universitet,Ortopedi,Forskargrupper vid Lunds universitet,Orthopedics,Lund University Research Groups
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Martin, Sean A. (författare)
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- Matsumoto, Alvin M. (författare)
- Washington University School of Medicine
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- Mellström, Dan (författare)
- Sahlgrenska Academy
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- Ohlsson, Claes (författare)
- Sahlgrenska Academy
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- O'Neill, Terence W (författare)
- Centre for Epidemiology Versus Arthritis
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- Orwoll, Eric S. (författare)
- Oregon Health & Science University
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- Quartagno, Matteo (författare)
- University College London
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- Shores, Molly M. (författare)
- Washington University School of Medicine
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- Steveling, Antje (författare)
- University Hospital Greifswald
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- Tivesten, Åsa (författare)
- Sahlgrenska University Hospital, Wallenberg Laboratory
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- Travison, Thomas G. (författare)
- Harvard Medical School
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- Vanderschueren, Dirk (författare)
- Catholic University of Leuven
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- Wittert, Gary A. (författare)
- University of Adelaide
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- Wu, Frederick C.W. (författare)
- University of Manchester
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Yeap, Bu B. (författare)
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(creator_code:org_t)
- 2023
- 2023
- Engelska 14 s.
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Ingår i: Annals of Internal Medicine. - 0003-4819. ; 176:9, s. 1221-1234
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.7...
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Abstract
Ämnesord
Stäng
- Background: Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements. Purpose: To clarify factors associated with variations in sex hormone concentrations. Data Sources: Systematic literature searches (to July 2019). Study Selection: Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry. Data Extraction: Individual participant data (IPD) (9 studies; n = 21 074) and aggregate data (2 studies; n = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone–binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted. Data Synthesis: Two-stage random-effects IPD meta-analyses found a nonlinear association of testosterone with age, with negligible change among men aged 17 to 70 years (change per SD increase about the midpoint, -0.27 nmol/L [-7.8 ng/dL] [CI, -0.71 to 0.18 nmol/L {-20.5 to 5.2 ng/dL}]) and decreasing testosterone levels with age for men older than 70 years (-1.55 nmol/L [-44.7 ng/dL] [CI, -2.05 to -1.06 nmol/L {-59.1 to -30.6 ng/dL}]). Testosterone was inversely associated with body mass index (BMI) (change per SD increase, -2.42 nmol/L [-69.7 ng/dL] [CI, -2.70 to -2.13 nmol/L {-77.8 to -61.4 ng/dL}]). Testosterone concentrations were lower for men who were married (mean difference, -0.57 nmol/L [-16.4 ng/dL] [CI, -0.89 to -0.26 nmol/L {-25.6 to -7.5 ng/dL}]); undertook at most 75 minutes of vigorous physical activity per week (-0.51 nmol/L [-14.7 ng/dL] [CI, -0.90 to -0.13 nmol/L {-25.9 to -3.7 ng/dL}]); were former smokers (-0.34 nmol/L [-9.8 ng/dL] [CI, -0.55 to -0.12 nmol/L {-15.9 to -3.5 ng/dL}]); or had hypertension (-0.53 nmol/L [-15.3 ng/dL] [CI, -0.82 to -0.24 nmol/L {-23.6 to -6.9 ng/dL}]), cardiovascular disease (-0.35 nmol/L [-10.1 ng/dL] [CI, -0.55 to -0.15 nmol/L {-15.9 to -4.3 ng/dL}]), cancer (-1.39 nmol/L [-40.1 ng/dL] [CI, -1.79 to -0.99 nmol/L {-51.6 to -28.5 ng/dL}]), or diabetes (-1.43 nmol/L [-41.2 ng/dL] [CI, -1.65 to -1.22 nmol/L {-47.6 to -35.2 ng/dL}]). Sex hormone–binding globulin was directly associated with age and inversely associated with BMI. Luteinizing hormone was directly associated with age in men older than 70 years. Limitation: Cross-sectional analysis, heterogeneity between studies and in timing of blood sampling, and imputation for missing data. Conclusion: Multiple factors are associated with variation in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function after age 70 years. Interpretation of individual testosterone measurements should account particularly for age older than 70 years, obesity, diabetes, and cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
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Marriott, Ross J ...
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Murray, Kevin
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Adams, Robert J.
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Antonio, Leen
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Ballantyne, Chri ...
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Bauer, Douglas C ...
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Bhasin, Shalende ...
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Biggs, Mary L.
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Cawthon, Peggy M ...
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Couper, David J.
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Dobs, Adrian S.
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Flicker, Leon
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Handelsman, Davi ...
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Hankey, Graeme J ...
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Hannemann, Anke
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Haring, Robin
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Hsu, Benjumin
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Karlsson, Magnus
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Martin, Sean A.
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Matsumoto, Alvin ...
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Mellström, Dan
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Ohlsson, Claes
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O'Neill, Terence ...
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Orwoll, Eric S.
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Quartagno, Matte ...
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Shores, Molly M.
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Steveling, Antje
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Tivesten, Åsa
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Travison, Thomas ...
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Vanderschueren, ...
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Wittert, Gary A.
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Wu, Frederick C. ...
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Yeap, Bu B.
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och Klinisk medicin
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