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Tumour growth fract...
Tumour growth fraction and apoptosis in salivary gland acinic cell carcinomas : Prognostic implications of Ki-67 and bcl-2 expression and of in situ end labelling (TUNEL)
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Hellquist, Henrik B. (författare)
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- Sundelin, Kaarina (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet,Öronkliniken US
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- DiBacco, A. (författare)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
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- Tytor, Maria (författare)
- Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
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- Manzotti, Michela (författare)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
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- Viale, Giuseppe J. (författare)
- Department of Pathology and Laboratory Medicine, European Institute of Oncology, Milan University School of Medicine, Milan, Italy
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: The Journal of Pathology. - 0031-3025 .- 1465-3931. ; 181:3, s. 323-329
- Relaterad länk:
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http://urn.kb.se/res...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- bcl-2 protein and Ki-67 (MIB-1) were studied in 32 acinic cell carcinomas (ACCs), all with a minimum of 5 years' clinical follow-up. Tumour apoptosis was evaluated by TdT dUTP nick end labelling (TUNEL) and by morphological criteria. Five patients died of their disease. Patients with stage I tumours had significantly better survival compared with other stages (P<0·05). Patients with MIB-1-negative tumours had significantly better survival than patients with MIB-1-positive tumours (P=0·05). This study confirms a previous report that MIB-1 is an independent prognostic factor for survival in patients with ACC. Stage I tumours had high expression of bcl-2 protein, but there was no difference when compared with other stages. TUNEL positivity was most prevalent in stage I tumours, compared with stages II, III, and IV (P<0·05), probably indicating more apoptosis. This could imply a capacity of stage I tumours ('early tumours') for early selection of tumour cells for elimination by apoptosis. There was no significant difference between expression of bcl-2 and TUNEL, between these parameters and clinical outcome, or between any parameter and morphological subclassification. We conclude that MIB-1 has prognostic value in ACC. Clinical staging, bcl-2, and TUNEL are also potentially useful as prognostic markers.
Nyckelord
- apoptosis
- bcl-2
- TUNEL
- end labelling
- salivary neoplasm
- Ki-67
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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