WFRF:(Hemani G)
Sökning: WFRF:(Hemani G) > (2020-2023) > Avoiding dynastic, ...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03255naa a2200649 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:144215256 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442152562 URI |
| 024 | 7 | a https://doi.org/10.1038/s41467-020-17117-42 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brumpton, B4 aut |
| 245 | 1 0 | a Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses |
| 264 | c 2020-07-14 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and use simulation studies to show that family-based analyses can reduce such biases. We illustrate empirically how familial effects can affect estimates using data from 61,008 siblings from the Nord-Trøndelag Health Study and UK Biobank and replicated our findings using 222,368 siblings from 23andMe. Both Mendelian randomization estimates using unrelated individuals and within family methods reproduced established effects of lower BMI reducing risk of diabetes and high blood pressure. However, while Mendelian randomization estimates from samples of unrelated individuals suggested that taller height and lower BMI increase educational attainment, these effects were strongly attenuated in within-family Mendelian randomization analyses. Our findings indicate the necessity of controlling for population structure and familial effects in Mendelian randomization studies. | |
| 700 | 1 | a Sanderson, E4 aut |
| 700 | 1 | a Heilbron, K4 aut |
| 700 | 1 | a Hartwig, FP4 aut |
| 700 | 1 | a Harrison, S4 aut |
| 700 | 1 | a Vie, GA4 aut |
| 700 | 1 | a Cho, Y4 aut |
| 700 | 1 | a Howe, LD4 aut |
| 700 | 1 | a Hughes, A4 aut |
| 700 | 1 | a Boomsma, DI4 aut |
| 700 | 1 | a Havdahl, A4 aut |
| 700 | 1 | a Hopper, J4 aut |
| 700 | 1 | a Neale, M4 aut |
| 700 | 1 | a Nivard, MG4 aut |
| 700 | 1 | a Pedersen, NLu Karolinska Institutet4 aut |
| 700 | 1 | a Reynolds, CA4 aut |
| 700 | 1 | a Tucker-Drob, EM4 aut |
| 700 | 1 | a Grotzinger, A4 aut |
| 700 | 1 | a Howe, L4 aut |
| 700 | 1 | a Morris, T4 aut |
| 700 | 1 | a Li, S4 aut |
| 700 | 1 | a Auton, A4 aut |
| 700 | 1 | a Windmeijer, F4 aut |
| 700 | 1 | a Chen, WM4 aut |
| 700 | 1 | a Bjorngaard, JH4 aut |
| 700 | 1 | a Hveem, K4 aut |
| 700 | 1 | a Willer, C4 aut |
| 700 | 1 | a Evans, DM4 aut |
| 700 | 1 | a Kaprio, J4 aut |
| 700 | 1 | a Smith, GD4 aut |
| 700 | 1 | a Asvold, BO4 aut |
| 700 | 1 | a Hemani, G4 aut |
| 700 | 1 | a Davies, NM4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 11:1, s. 3519-q 11:1<3519-x 2041-1723 |
| 856 | 4 | u https://www.nature.com/articles/s41467-020-17117-4.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:144215256 |
| 856 | 4 8 | u https://doi.org/10.1038/s41467-020-17117-4 |
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- Brumpton, B
- Sanderson, E
- Heilbron, K
- Hartwig, FP
- Harrison, S
- Vie, GA
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- Cho, Y
- Howe, LD
- Hughes, A
- Boomsma, DI
- Havdahl, A
- Hopper, J
- Neale, M
- Nivard, MG
- Pedersen, NL
- Reynolds, CA
- Tucker-Drob, EM
- Grotzinger, A
- Howe, L
- Morris, T
- Li, S
- Auton, A
- Windmeijer, F
- Chen, WM
- Bjorngaard, JH
- Hveem, K
- Willer, C
- Evans, DM
- Kaprio, J
- Smith, GD
- Asvold, BO
- Hemani, G
- Davies, NM
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