WFRF:(Hoffmann Katrin)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08902naa a2202029 4500 | |
| 001 | oai:gup.ub.gu.se/268852 | |
| 003 | SwePub | |
| 008 | 240528s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:140390285 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2688522 URI |
| 024 | 7 | a https://doi.org/10.1111/bdi.126592 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1403902852 URI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kalman, Janos L4 aut |
| 245 | 1 0 | a Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study. |
| 264 | c 2018-06-28 | |
| 264 | 1 | b Wiley,c 2019 |
| 520 | a Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients.A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18years] vs adulthood [>18years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models.BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment.The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 700 | 1 | a Papiol, Sergi4 aut |
| 700 | 1 | a Forstner, Andreas J4 aut |
| 700 | 1 | a Heilbronner, Urs4 aut |
| 700 | 1 | a Degenhardt, Franziska4 aut |
| 700 | 1 | a Strohmaier, Jana4 aut |
| 700 | 1 | a Adli, Mazda4 aut |
| 700 | 1 | a Adorjan, Kristina4 aut |
| 700 | 1 | a Akula, Nirmala4 aut |
| 700 | 1 | a Alda, Martin4 aut |
| 700 | 1 | a Anderson-Schmidt, Heike4 aut |
| 700 | 1 | a Andlauer, Till Fm4 aut |
| 700 | 1 | a Anghelescu, Ion-George4 aut |
| 700 | 1 | a Ardau, Raffaella4 aut |
| 700 | 1 | a Arias, Bárbara4 aut |
| 700 | 1 | a Arolt, Volker4 aut |
| 700 | 1 | a Aubry, Jean-Michel4 aut |
| 700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
| 700 | 1 | a Bartholdi, Kim4 aut |
| 700 | 1 | a Bauer, Michael4 aut |
| 700 | 1 | a Baune, Bernhard T4 aut |
| 700 | 1 | a Becker, Thomas4 aut |
| 700 | 1 | a Bellivier, Frank4 aut |
| 700 | 1 | a Benabarre, Antonio4 aut |
| 700 | 1 | a Bengesser, Susanne4 aut |
| 700 | 1 | a Bhattacharjee, Abesh Kumar4 aut |
| 700 | 1 | a Biernacka, Joanna M4 aut |
| 700 | 1 | a Birner, Armin4 aut |
| 700 | 1 | a Brichant-Petitjean, Clara4 aut |
| 700 | 1 | a Budde, Monika4 aut |
| 700 | 1 | a Cervantes, Pablo4 aut |
| 700 | 1 | a Chillotti, Caterinau Karolinska Institutet4 aut |
| 700 | 1 | a Cichon, Sven4 aut |
| 700 | 1 | a Clark, Scott R4 aut |
| 700 | 1 | a Colom, Francesc4 aut |
| 700 | 1 | a Comes, Ashley L4 aut |
| 700 | 1 | a Cruceanu, Cristiana4 aut |
| 700 | 1 | a Czerski, Piotr M4 aut |
| 700 | 1 | a Dannlowski, Udo4 aut |
| 700 | 1 | a Dayer, Alexandre4 aut |
| 700 | 1 | a Del Zompo, Maria4 aut |
| 700 | 1 | a DePaulo, Jay Raymond4 aut |
| 700 | 1 | a Dietrich, Detlef E4 aut |
| 700 | 1 | a Étain, Bruno4 aut |
| 700 | 1 | a Ethofer, Thomas4 aut |
| 700 | 1 | a Falkai, Peter4 aut |
| 700 | 1 | a Fallgatter, Andreas4 aut |
| 700 | 1 | a Figge, Christian4 aut |
| 700 | 1 | a Flatau, Laura4 aut |
| 700 | 1 | a Folkerts, Here4 aut |
| 700 | 1 | a Frisen, Louiseu Karolinska Institutet4 aut |
| 700 | 1 | a Frye, Mark A4 aut |
| 700 | 1 | a Fullerton, Janice M4 aut |
| 700 | 1 | a Gade, Katrin4 aut |
| 700 | 1 | a Gard, Sébastien4 aut |
| 700 | 1 | a Garnham, Julie S4 aut |
| 700 | 1 | a Goes, Fernando S4 aut |
| 700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
| 700 | 1 | a Gryaznova, Anna4 aut |
| 700 | 1 | a Hake, Maria4 aut |
| 700 | 1 | a Hauser, Joanna4 aut |
| 700 | 1 | a Herms, Stefan4 aut |
| 700 | 1 | a Hoffmann, Per4 aut |
| 700 | 1 | a Hou, Liping4 aut |
| 700 | 1 | a Jäger, Markus4 aut |
| 700 | 1 | a Jamain, Stephane4 aut |
| 700 | 1 | a Jiménez, Esther4 aut |
| 700 | 1 | a Juckel, Georg4 aut |
| 700 | 1 | a Kahn, Jean-Pierre4 aut |
| 700 | 1 | a Kassem, Layla4 aut |
| 700 | 1 | a Kelsoe, John4 aut |
| 700 | 1 | a Kittel-Schneider, Sarah4 aut |
| 700 | 1 | a Kliwicki, Sebastian4 aut |
| 700 | 1 | a Klohn-Sagatholislam, Farah4 aut |
| 700 | 1 | a Koller, Manfred4 aut |
| 700 | 1 | a König, Barbara4 aut |
| 700 | 1 | a Konrad, Carsten4 aut |
| 700 | 1 | a Lackner, Nina4 aut |
| 700 | 1 | a Laje, Gonzalo4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Lang, Fabian U4 aut |
| 700 | 1 | a Lavebratt, Catharina4 aut |
| 700 | 1 | a Leboyer, Marion4 aut |
| 700 | 1 | a Leckband, Susan G4 aut |
| 700 | 1 | a Maj, Mariou Karolinska Institutet4 aut |
| 700 | 1 | a Manchia, Mirko4 aut |
| 700 | 1 | a Martinsson, Linau Karolinska Institutet4 aut |
| 700 | 1 | a McCarthy, Michael J4 aut |
| 700 | 1 | a McElroy, Susan L4 aut |
| 700 | 1 | a McMahon, Francis J4 aut |
| 700 | 1 | a Mitchell, Philip B4 aut |
| 700 | 1 | a Mitjans, Marina4 aut |
| 700 | 1 | a Mondimore, Francis M4 aut |
| 700 | 1 | a Monteleone, Palmiero4 aut |
| 700 | 1 | a Nieratschker, Vanessa4 aut |
| 700 | 1 | a Nievergelt, Caroline M4 aut |
| 700 | 1 | a Novák, Tomas4 aut |
| 700 | 1 | a Ösby, Urban4 aut |
| 700 | 1 | a Pfennig, Andrea4 aut |
| 700 | 1 | a Potash, James B4 aut |
| 700 | 1 | a Reich-Erkelenz, Daniela4 aut |
| 700 | 1 | a Reif, Andreas4 aut |
| 700 | 1 | a Reimer, Jens4 aut |
| 700 | 1 | a Reininghaus, Eva4 aut |
| 700 | 1 | a Reitt, Markus4 aut |
| 700 | 1 | a Ripke, Stephan4 aut |
| 700 | 1 | a Rouleau, Guy A4 aut |
| 700 | 1 | a Rybakowski, Janusz K4 aut |
| 700 | 1 | a Schalling, Martin4 aut |
| 700 | 1 | a Scherk, Harald4 aut |
| 700 | 1 | a Schmauß, Max4 aut |
| 700 | 1 | a Schofield, Peter R4 aut |
| 700 | 1 | a Schubert, K Oliver4 aut |
| 700 | 1 | a Schulte, Eva C4 aut |
| 700 | 1 | a Schulz, Sybille4 aut |
| 700 | 1 | a Senner, Fanny4 aut |
| 700 | 1 | a Severino, Giovanni4 aut |
| 700 | 1 | a Shekhtman, Tatyana4 aut |
| 700 | 1 | a Shilling, Paul D4 aut |
| 700 | 1 | a Simhandl, Christian4 aut |
| 700 | 1 | a Slaney, Claire M4 aut |
| 700 | 1 | a Spitzer, Carsten4 aut |
| 700 | 1 | a Squassina, Alessio4 aut |
| 700 | 1 | a Stamm, Thomas4 aut |
| 700 | 1 | a Stegmaier, Sophia4 aut |
| 700 | 1 | a Stierl, Sebastian4 aut |
| 700 | 1 | a Stopkova, Pavla4 aut |
| 700 | 1 | a Thiel, Andreas4 aut |
| 700 | 1 | a Tighe, Sarah K4 aut |
| 700 | 1 | a Tortorella, Alfonso4 aut |
| 700 | 1 | a Turecki, Gustavo4 aut |
| 700 | 1 | a Vieta, Eduard4 aut |
| 700 | 1 | a Veeh, Julia4 aut |
| 700 | 1 | a von Hagen, Martin4 aut |
| 700 | 1 | a Wigand, Moritz E4 aut |
| 700 | 1 | a Wiltfang, Jens4 aut |
| 700 | 1 | a Witt, Stephanie4 aut |
| 700 | 1 | a Wright, Adam4 aut |
| 700 | 1 | a Zandi, Peter P4 aut |
| 700 | 1 | a Zimmermann, Jörg4 aut |
| 700 | 1 | a Nöthen, Markus4 aut |
| 700 | 1 | a Rietschel, Marcella4 aut |
| 700 | 1 | a Schulze, Thomas G4 aut |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t Bipolar disordersd : Wileyg 21:1, s. 68-75q 21:1<68-75x 1399-5618x 1398-5647 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bdi.12659 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/268852 |
| 856 | 4 8 | u https://doi.org/10.1111/bdi.12659 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140390285 |
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