Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium

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Quantification of [(11)C]-meta-hydroxyephedrine uptake in human myocardium

Harms, Hendrik J (author)

de Haan, Stefan (author)

Knaapen, Paul (author)

Allaart, Cornelis P (author)

Rijnierse, Mischa T (author)

Schuit, Robert C (author)

Windhorst, Albert D (author)

Lammertsma, Adriaan A (author)

Huisman, Marc C (author)

Lubberink, Mark (author): Uppsala universitet,Enheten för nuklearmedicin och PET

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2014-09-26
2014
English.
In: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 4

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://ejnmmires.sp...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: The aims of this study were to determine the optimal tracer kinetic model for [(11)C]-meta-hydroxyephedrine ([(11)C]HED) and to evaluate the performance of several simplified methods.METHODS: Thirty patients underwent dynamic 60-min [(11)C]HED scans with online arterial blood sampling. Single-tissue and both reversible and irreversible two-tissue models were fitted to the data using the metabolite-corrected arterial input function. For each model, reliable fits were defined as those yielding outcome parameters with a coefficient of variation (CoV) <25%. The optimal model was determined using Akaike and Schwarz criteria and the F-test, together with the number of reliable fits. Simulations were performed to study accuracy and precision of each model. Finally, quantitative results obtained using a population-averaged metabolite correction were evaluated, and simplified retention index (RI) and standardized uptake value (SUV) results were compared with quantitative volume of distribution (V T) data.RESULTS: The reversible two-tissue model was preferred in 75.8% of all segments, based on the Akaike information criterion. However, V T derived using the single-tissue model correlated highly with that of the two-tissue model (r (2) = 0.94, intraclass correlation coefficient (ICC) = 0.96) and showed higher precision (CoV of 24.6% and 89.2% for single- and two-tissue models, respectively, at 20% noise). In addition, the single-tissue model yielded reliable fits in 94.6% of all segments as compared with 77.1% for the reversible two-tissue model. A population-averaged metabolite correction could not be used in approximately 20% of the patients because of large biases in V T. RI and SUV can provide misleading results because of non-linear relationships with V T.CONCLUSIONS: Although the reversible two-tissue model provided the best fits, the single-tissue model was more robust and results obtained were similar. Therefore, the single-tissue model was preferred. RI showed a non-linear correlation with V T, and therefore, care has to be taken when using RI as a quantitative measure.

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By the author/editor: Harms, Hendrik J; de Haan, Stefan; Knaapen, Paul; Allaart, Corneli ...; Rijnierse, Misch ...; Schuit, Robert C; show more...; Windhorst, Alber ...; Lammertsma, Adri ...; Huisman, Marc C; Lubberink, Mark; show less...

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