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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007381naa a2200889 4500
001oai:DiVA.org:liu-202360
003SwePub
008240412s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:238194459
009oai:prod.swepub.kib.ki.se:155276806
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2023602 URI
0247 a https://doi.org/10.1073/pnas.23153541202 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:2381944592 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1552768062 URI
040 a (SwePub)liud (SwePub)kid (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Marcotte, Haroldu Karolinska Inst, Sweden4 aut
2451 0a Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents Infection of Omicron lineages
264 1b NATL ACAD SCIENCES,c 2024
338 a print2 rdacarrier
520 a The emergence of Omicron lineages and descendent subvariants continues to present a severe threat to the effectiveness of vaccines and therapeutic antibodies. We have previ- ously suggested that an insufficient mucosal immunoglobulin A (IgA) response induced by the mRNA vaccines is associated with a surge in breakthrough infections. Here, we further show that the intramuscular mRNA and/or inactivated vaccines cannot suffi- ciently boost the mucosal secretory IgA response in uninfected individuals, particu- larly against the Omicron variant. We thus engineered and characterized recombinant monomeric, dimeric, and secretory IgAl antibodies derived from four neutralizing IgG monoclonal antibodies (mAbs 01A05, rmAb23, DXP-604, and XG014) targeting the receptor-binding domain of the spike protein. Compared to their parental IgG antibod- ies, dimeric and secretory IgAl antibodies showed a higher neutralizing activity against different variants of concern (VOCs), in part due to an increased avidity. Importantly, the dimeric or secretory IgAl form of the DXP-604 antibody significantly outperformed its parental IgG antibody, and neutralized the Omicron lineages BA.1, BA.2, and BA.4/5 with a 25- to 75-fold increase in potency. In human angiotensin converting enzyme 2 (ACE2) transgenic mice, a single intranasal dose of the dimeric IgA DXP-604 conferred prophylactic and therapeutic protection against Omicron BA.5. Thus, dimeric or secre- tory IgA delivered by nasal administration may potentially be exploited for the treatment Iand prevention of Omicron infection, thereby providing an alternative tool for combating immune evasion by the current circulating subvariants and, potentially, future VOCs.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a ISA; SARS COV-2; Omicron; antibody engineering; antibody therapy
7001 a Cao, Yunlongu Changping Lab, Peoples R China; Peking Univ, Peoples R China4 aut
7001 a Zuo, Fangleiu Karolinska Inst, Sweden4 aut
7001 a Simonelli, Lucau Univ Svizzera italiana, Switzerland4 aut
7001 a Sammartino, Jose Camillau Fdn Ist Ricovero & Cura Carattere Sci IRCCS Policl, Italy4 aut
7001 a Pedotti, Mattiau Univ Svizzera italiana, Switzerland4 aut
7001 a Sun, Ruiu Karolinska Inst, Sweden4 aut
7001 a Cassaniti, Ireneu Fdn Ist Ricovero & Cura Carattere Sci IRCCS Policl, Italy4 aut
7001 a Hagbom, Marieu Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten4 aut0 (Swepub:liu)marha48
7001 a Piralla, Antoniou Fdn Ist Ricovero & Cura Carattere Sci IRCCS Policl, Italy4 aut
7001 a Yang, Jinxuanu Chinese Acad Sci, Peoples R China4 aut
7001 a Du, Likunu Karolinska Inst, Sweden4 aut
7001 a Percivalle, Elenau Fdn Ist Ricovero & Cura Carattere Sci IRCCS Policl, Italy4 aut
7001 a Bertoglio, Federicou Tech Univ Carolo Wilhelmina Braunschweig, Germany4 aut
7001 a Schubert, Marenu Tech Univ Carolo Wilhelmina Braunschweig, Germany4 aut
7001 a Abolhassani, Hassanu Karolinska Institutet,Karolinska Inst, Sweden4 aut
7001 a Sherina, Nataliau Karolinska Inst, Sweden4 aut
7001 a Guerra, Concettau Univ Svizzera italiana, Switzerland4 aut
7001 a Borte, Stephanu Hosp St Georg, Germany; Hosp St Georg, Germany4 aut
7001 a Rezaei, Nimau Univ Tehran Med Sci, Iran4 aut
7001 a Kumagai-Braesch, Makikou Karolinska Inst, Sweden4 aut
7001 a Xue, Yintongu Peking Univ, Peoples R China4 aut
7001 a Su, Chenu Peking Univ, Peoples R China4 aut
7001 a Yan, Qihongu Karolinska Institutet,Chinese Acad Sci, Peoples R China,Karolinska Inst, Sweden4 aut
7001 a He, Pingu Chinese Acad Sci, Peoples R China4 aut
7001 a Groenwall, Carolineu Karolinska Univ Hosp, Sweden4 aut
7001 a Klareskog, Larsu Karolinska Univ Hosp, Sweden4 aut
7001 a Calzolai, Luigiu European Commiss, Italy4 aut
7001 a Cavalli, Andreau Univ Svizzera italiana, Switzerland4 aut
7001 a Wang, Qiaou Fudan Univ, Peoples R China4 aut
7001 a Robbiani, Davide F.u Univ Svizzera italiana, Switzerland4 aut
7001 a Hust, Michaelu Tech Univ Carolo Wilhelmina Braunschweig, Germany4 aut
7001 a Shi, Zhengliu Chinese Acad Sci, Peoples R China4 aut
7001 a Feng, Liqiangu Chinese Acad Sci, Peoples R China4 aut
7001 a Svensson, Lennartu Linköpings universitet,Avdelningen för molekylär medicin och virologi,Medicinska fakulteten,Karolinska Inst, Sweden4 aut0 (Swepub:liu)lensv66
7001 a Chen, Lingu Guangzhou Lab, Peoples R China4 aut
7001 a Bao, Linlinu Inst Lab Anim Sci, Peoples R China; Peking Union Med Coll, Peoples R China; Natl Ctr Technol Innovat Anim Model, Peoples R China4 aut
7001 a Baldanti, Faustou Fdn Ist Ricovero & Cura Carattere Sci IRCCS Policl, Italy; Univ Pavia, Italy4 aut
7001 a Xiao, Junyuu Changping Lab, Peoples R China4 aut
7001 a Qin, Chuanu Inst Lab Anim Sci, Peoples R China; Peking Union Med Coll, Peoples R China; Natl Ctr Technol Innovat Anim Model, Peoples R China4 aut
7001 a Hammarstrom, Lennartu Karolinska Inst, Sweden4 aut
7001 a Yang, Xinglouu Chinese Acad Sci, Peoples R China4 aut
7001 a Varani, Lucau Univ Svizzera italiana, Switzerland4 aut
7001 a Xie, Xiaoliang Sunneyu Changping Lab, Peoples R China; Peking Univ, Peoples R China4 aut
7001 a Pan-Hammarstrom, Qiangu Karolinska Inst, Sweden4 aut
7102 a Karolinska Inst, Swedenb Changping Lab, Peoples R China; Peking Univ, Peoples R China4 org
7730 t Proceedings of the National Academy of Sciences of the United States of Americad : NATL ACAD SCIENCESg 121:3q 121:3x 0027-8424x 1091-6490
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-202360
8564 8u https://doi.org/10.1073/pnas.2315354120
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:238194459
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:155276806

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