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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004695naa a2200685 4500
001oai:DiVA.org:uu-171358
003SwePub
008120317s2008 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:116839058
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1713582 URI
0247 a https://doi.org/10.1007/s00401-008-0360-82 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1168390582 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bell, Jeanne E4 aut
2451 0a Management of a twenty-first century brain bank :b experience in the BrainNet Europe consortium.
264 c 2008-03-26
264 1b Springer Science and Business Media LLC,c 2008
338 a print2 rdacarrier
520 a Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the sharing of protocols and development of best practice and quality control. One aspect of this collective experience concerns brain bank management, excellence in which is a prerequisite not only for gaining the trust of potential donors and of society in general, but also for ensuring equitable distribution to researchers of high quality tissue samples. This review addresses the legal, ethical and governance issues, tissue quality, and health and safety aspects of brain bank management and data management in a network, as well as the needs of users, brain bank staffing, donor programs, funding issues and public relations. Recent developments in research methodology present new opportunities for researchers who use brain tissue samples, but will require brain banks to adopt more complex protocols for tissue collection, preparation and storage, with inevitable cost implications for the future.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a Pathology
653 a Patologi
7001 a Alafuzoff, Irinau Department of Neuroscience and Neurology, University of Kuopio Finland4 aut
7001 a Al-Sarraj, Safa4 aut
7001 a Arzberger, Thomas4 aut
7001 a Bogdanovic, Nenadu Karolinska Institutet4 aut
7001 a Budka, Herbert4 aut
7001 a Dexter, David T4 aut
7001 a Falkai, Peter4 aut
7001 a Ferrer, Isidro4 aut
7001 a Gelpi, Elena4 aut
7001 a Gentleman, Steven M4 aut
7001 a Giaccone, Giorgio4 aut
7001 a Huitinga, Inge4 aut
7001 a Ironside, James W4 aut
7001 a Klioueva, Natasja4 aut
7001 a Kovacs, Gabor G4 aut
7001 a Meyronet, David4 aut
7001 a Palkovits, Miklos4 aut
7001 a Parchi, Piero4 aut
7001 a Patsouris, Efstatios4 aut
7001 a Reynolds, Richard4 aut
7001 a Riederer, Peter4 aut
7001 a Roggendorf, Wolfgang4 aut
7001 a Seilhean, Danielle4 aut
7001 a Schmitt, Andrea4 aut
7001 a Schmitz, Peer4 aut
7001 a Streichenberger, Nathalie4 aut
7001 a Schwalber, Ameli4 aut
7001 a Kretzschmar, Hans4 aut
7102 a Karolinska Institutetb Department of Neuroscience and Neurology, University of Kuopio Finland4 org
7730 t Acta Neuropathologicad : Springer Science and Business Media LLCg 115:5, s. 497-507q 115:5<497-507x 0001-6322x 1432-0533
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171358
8564 8u https://doi.org/10.1007/s00401-008-0360-8
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:116839058

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