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Sökning: WFRF:(Jack Clifford R.) > (2020-2024) > Amyloid and tau PET...

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FältnamnIndikatorerMetadata
00007384naa a2200733 4500
001oai:lup.lub.lu.se:708ac86f-22eb-4397-a375-420c089e86b5
003SwePub
008221128s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/708ac86f-22eb-4397-a375-420c089e86b52 URI
0247 a https://doi.org/10.1038/s41591-022-02049-x2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam Neuroscience4 aut0 (Swepub:lu)ri1513os
2451 0a Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline
264 c 2022-11-10
264 1b Springer Science and Business Media LLC,c 2022
300 a 7 s.
520 a A major unanswered question in the dementia field is whether cognitively unimpaired individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is, amyloid-β plaques and tau neurofibrillary tangles) can preserve their cognition over time or are destined to decline. In this large multicenter amyloid and tau positron emission tomography (PET) study (n = 1,325), we examined the risk for future progression to mild cognitive impairment and the rate of cognitive decline over time among cognitively unimpaired individuals who were amyloid PET-positive (A+) and tau PET-positive (T+) in the medial temporal lobe (A+TMTL+) and/or in the temporal neocortex (A+TNEO-T+) and compared them with A+T- and A-T- groups. Cox proportional-hazards models showed a substantially increased risk for progression to mild cognitive impairment in the A+TNEO-T+ (hazard ratio (HR) = 19.2, 95% confidence interval (CI) = 10.9-33.7), A+TMTL+ (HR = 14.6, 95% CI = 8.1-26.4) and A+T- (HR = 2.4, 95% CI = 1.4-4.3) groups versus the A-T- (reference) group. Both A+TMTL+ (HR = 6.0, 95% CI = 3.4-10.6) and A+TNEO-T+ (HR = 7.9, 95% CI = 4.7-13.5) groups also showed faster clinical progression to mild cognitive impairment than the A+T- group. Linear mixed-effect models indicated that the A+TNEO-T+ (β = -0.056 ± 0.005, T = -11.55, P < 0.001), A+TMTL+ (β = -0.024 ± 0.005, T = -4.72, P < 0.001) and A+T- (β = -0.008 ± 0.002, T = -3.46, P < 0.001) groups showed significantly faster longitudinal global cognitive decline compared to the A-T- (reference) group (all P < 0.001). Both A+TNEO-T+ (P < 0.001) and A+TMTL+ (P = 0.002) groups also progressed faster than the A+T- group. In summary, evidence of advanced Alzheimer's disease pathological changes provided by a combination of abnormal amyloid and tau PET examinations is strongly associated with short-term (that is, 3-5 years) cognitive decline in cognitively unimpaired individuals and is therefore of high clinical relevance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Humans
653 a Alzheimer Disease/pathology
653 a tau Proteins/metabolism
653 a Brain/metabolism
653 a Cognitive Dysfunction/diagnostic imaging
653 a Positron-Emission Tomography/methods
653 a Amyloid/metabolism
653 a Amyloid beta-Peptides/metabolism
653 a Amyloidosis
653 a Plaque, Amyloid
653 a Biomarkers
7001 a Pichet Binette, Alexau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)al1314pi
7001 a Groot, Colinu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam Neuroscience4 aut0 (Swepub:lu)co1654gr
7001 a Smith, Rubenu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-rsm
7001 a Strandberg, Olofu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)teor-osn
7001 a Palmqvist, Sebastianu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Tideman, Pontusu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)po1670pa
7001 a Ohlsson, Tomasu Skåne University Hospital4 aut
7001 a Jögi, Jonasu Skåne University Hospital4 aut0 (Swepub:lu)klin-jjo
7001 a Johnson, Keithu Harvard Medical School,Massachusetts General Hospital4 aut
7001 a Sperling, Reisau Massachusetts General Hospital,Harvard Medical School4 aut
7001 a Dore, Vincentu Austin Health,CSIRO E-Health Research Center4 aut
7001 a Masters, Colin Lu The Florey Institute of Neuroscience and Mental Health4 aut
7001 a Rowe, Christopheru The Florey Institute of Neuroscience and Mental Health,Austin Health4 aut
7001 a Visser, Deniseu Amsterdam Neuroscience,Vrije Universiteit Amsterdam4 aut
7001 a van Berckel, Bart N Mu Amsterdam Neuroscience,Vrije Universiteit Amsterdam4 aut
7001 a van der Flier, Wiesje Mu Amsterdam Neuroscience,Vrije Universiteit Amsterdam4 aut
7001 a Baker, Suzanneu Lawrence Berkeley National Laboratory4 aut
7001 a Jagust, William Ju Lawrence Berkeley National Laboratory,University of California, Berkeley4 aut
7001 a Wiste, Heather Ju Mayo Clinic Minnesota4 aut
7001 a Petersen, Ronald Cu Mayo Clinic Minnesota4 aut
7001 a Jack, Clifford Ru Mayo Clinic Minnesota4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7102 a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
7730 t Nature Medicined : Springer Science and Business Media LLCg 28:11, s. 2381-2387q 28:11<2381-2387x 1546-170Xx 1078-8956
8564 u http://dx.doi.org/10.1038/s41591-022-02049-xx freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/708ac86f-22eb-4397-a375-420c089e86b5
8564 8u https://doi.org/10.1038/s41591-022-02049-x

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