WFRF:(Janoueix Lerosey I.)
Sökning: WFRF:(Janoueix Lerosey I.) > An integrative geno...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03638naa a2200577 4500 | |
| 001 | oai:lup.lub.lu.se:965ae2c6-2556-4dc2-86e7-f99a715ccb6f | |
| 003 | SwePub | |
| 008 | 160401s2010 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/16302862 URI |
| 024 | 7 | a https://doi.org/10.1038/onc.2010.1062 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Mestdagh, P.4 aut |
| 245 | 1 0 | a An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours |
| 264 | c 2010-04-12 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2010 |
| 520 | a Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010 | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a non-coding RNA | |
| 653 | a neuroblastoma | |
| 653 | a T-UCR | |
| 700 | 1 | a Fredlund, Eriku Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)molm-efr |
| 700 | 1 | a Pattyn, F.4 aut |
| 700 | 1 | a Rihani, A.4 aut |
| 700 | 1 | a Van Maerken, T.4 aut |
| 700 | 1 | a Vermeulen, J.4 aut |
| 700 | 1 | a Kumps, C.4 aut |
| 700 | 1 | a Menten, B.4 aut |
| 700 | 1 | a De Preter, K.4 aut |
| 700 | 1 | a Schramm, A.4 aut |
| 700 | 1 | a Schulte, J.4 aut |
| 700 | 1 | a Noguera, R.4 aut |
| 700 | 1 | a Schleiermacher, G.4 aut |
| 700 | 1 | a Janoueix-Lerosey, I.4 aut |
| 700 | 1 | a Laureys, G.4 aut |
| 700 | 1 | a Powel, R.4 aut |
| 700 | 1 | a Nittner, D.4 aut |
| 700 | 1 | a Marine, J-C4 aut |
| 700 | 1 | a Ringnér, Markusu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)thep-mri |
| 700 | 1 | a Speleman, F.4 aut |
| 700 | 1 | a Vandesompele, J.4 aut |
| 710 | 2 | a Bröstcancer-genetikb Sektion I4 org |
| 773 | 0 | t Oncogened : Springer Science and Business Media LLCg 29:24, s. 3583-3592q 29:24<3583-3592x 1476-5594x 0950-9232 |
| 856 | 4 | u http://dx.doi.org/10.1038/onc.2010.106y FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/onc2010106.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1630286 |
| 856 | 4 8 | u https://doi.org/10.1038/onc.2010.106 |
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- Rihani, A.
- Van Maerken, T.
- Vermeulen, J.
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- Kumps, C.
- Menten, B.
- De Preter, K.
- Schramm, A.
- Schulte, J.
- Noguera, R.
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- Janoueix-Lerosey ...
- Laureys, G.
- Powel, R.
- Nittner, D.
- Marine, J-C
- Ringnér, Markus
- Speleman, F.
- Vandesompele, J.
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