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HIV-2 as a model to...
HIV-2 as a model to identify a functional HIV cure
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- Esbjörnsson, Joakim (author)
- Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford
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- Jansson, Marianne (author)
- Lund University,Lunds universitet,HIV-1 och HIV-2 värd interaktioner,Forskargrupper vid Lunds universitet,HIV-1 and HIV-2 host interactions,Lund University Research Groups
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- Jespersen, Sanne (author)
- Aarhus University Hospital,Bandim Health Project
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- Månsson, Fredrik (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups
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- Hønge, Bo L. (author)
- Bandim Health Project,Aarhus University Hospital
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- Lindman, Jacob (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Medina, Candida (author)
- Ministry of Health, Guinea-Bissau
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- Da Silva, Zacarias J. (author)
- Ministry of Health, Guinea-Bissau,National Public Health Laboratory
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- Norrgren, Hans (author)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Medstrand, Patrik (author)
- Lund University,Lunds universitet,Klinisk virologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Virology, Malmö,Lund University Research Groups
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- Rowland-Jones, Sarah L. (author)
- University of Oxford
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- Wejse, Christian (author)
- Bandim Health Project,Aarhus University Hospital,Aarhus University
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(creator_code:org_t)
- 2019-09-05
- 2019
- English.
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In: AIDS Research and Therapy. - : Springer Science and Business Media LLC. - 1742-6405. ; 16:1
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Abstract
Subject headings
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- Two HIV virus types exist: HIV-1 is pandemic and aggressive, whereas HIV-2 is confined mainly to West Africa and less pathogenic. Despite the fact that it has been almost 40 years since the discovery of AIDS, there is still no cure or vaccine against HIV. Consequently, the concepts of functional vaccines and cures that aim to limit HIV disease progression and spread by persistent control of viral replication without life-long treatment have been suggested as more feasible options to control the HIV pandemic. To identify virus-host mechanisms that could be targeted for functional cure development, researchers have focused on a small fraction of HIV-1 infected individuals that control their infection spontaneously, so-called elite controllers. However, these efforts have not been able to unravel the key mechanisms of the infection control. This is partly due to lack in statistical power since only 0.15% of HIV-1 infected individuals are natural elite controllers. The proportion of long-Term viral control is larger in HIV-2 infection compared with HIV-1 infection. We therefore present the idea of using HIV-2 as a model for finding a functional cure against HIV. Understanding the key differences between HIV-1 and HIV-2 infections, and the cross-reactive effects in HIV-1/HIV-2 dual-infection could provide novel insights in developing functional HIV cures and vaccines.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- Disease progression
- Dual-infection
- Functional cure
- HIV-1
- HIV-2
- West Africa
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- ref (subject category)
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- By the author/editor
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Esbjörnsson, Joa ...
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Jansson, Mariann ...
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Jespersen, Sanne
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Månsson, Fredrik
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Hønge, Bo L.
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Lindman, Jacob
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show more...
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Medina, Candida
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Da Silva, Zacari ...
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Norrgren, Hans
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Medstrand, Patri ...
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Rowland-Jones, S ...
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Wejse, Christian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
- Articles in the publication
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AIDS Research an ...
- By the university
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Lund University