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Double-strand break...
Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers
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Neasham, David (author)
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Gallo, Valentina (author)
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Guarrera, Simonetta (author)
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Dunning, Alison (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Clavel-Chapelon, Francoise (author)
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Linseisen, Jakob P. (author)
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Malaveille, Christian (author)
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Ferrari, Pietro (author)
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Boeing, Heiner (author)
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Benetou, Vassiliki (author)
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Trichopoulou, Antonia (author)
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Palli, Domenico (author)
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Crosignani, Paolo (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Bueno-De-Mesquita, H. Bas (author)
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Peeters, Petra H. (author)
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van Gib, Carla H. (author)
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Lund, Eiliv (author)
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Gonzalez, Carlos A. (author)
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Martinez, Carmen (author)
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Dorronsoro, Miren (author)
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Barricarte, Aurelio (author)
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Navarro, Carmen (author)
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Quiros, Jose R. (author)
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- Berglund, Göran (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Jarvholm, Bengt (author)
- Umeå universitet,Yrkes- och miljömedicin
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Khaw, Kay Tee (author)
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Key, Timothy J. (author)
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Bingham, Sheila (author)
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Jose Diaz, Tormo M. (author)
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Riboli, Elio (author)
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Matullo, Giuseppe (author)
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Vineis, Paolo (author)
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: DNA Repair. - : Elsevier BV. - 1568-7856 .- 1568-7864. ; 8:1, s. 60-71
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- We followed-up for mortality and cancer incidence 1088 healthy non-smokers from a population-based study, who were characterized for 22 variants in 16 genes involved in DNA repair pathways. Follow-up was 100% complete. The association between polymorphism and mortality or cancer incidence was analyzed using Cox Proportional Hazard regression models. Ninety-five subjects had died in a median follow-up time of 78 months (inter-quartile range 59-93 months). None of the genotypes was clearly associated with total mortality, except variants for two Double-Strand Break DNA repair genes, XRCC3 18067 C > T (rs#861539) and XRCC2 31479 G > A (rs#3218536). Adjusted hazard ratios were 2.25 (1.32-3.83) for the XRCC3 C/T genotype and 2.04 (1.00-4.13) for the T/T genotype (reference C/C), and 2.12 (1.14-3.97) for the XRCC2 G/A genotype (reference G/G). For total cancer mortality, the adjusted hazard ratios were 3.29 (1.23-7.82) for XRCC3 C/T, 2.84 (0.81-9.90) for XRCC3 T/T and 3.17 (1.21-8.30) for XRCC2 G/A. With combinations of three or more adverse alleles, the adjusted hazard ratio for all cause mortality was 17.29 (95% C.I. 8.13-36.74), and for all incident cancers the HR was 5.28 (95% C.I. 2.17-12.85). Observations from this prospective study suggest that polymorphisms of genes involved in the repair of DNA double-strand breaks significantly influence the risk of cancer and non-cancer disease, and call influence mortality. (C) 2008 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Mortality
- DNA repair
- Prospective study
- Cancer
Publication and Content Type
- art (subject category)
- ref (subject category)
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DNA Repair
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- By the author/editor
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Neasham, David
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Gallo, Valentina
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Guarrera, Simone ...
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Dunning, Alison
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Overvad, Kim
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Tjonneland, Anne
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show more...
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Clavel-Chapelon, ...
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Linseisen, Jakob ...
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Malaveille, Chri ...
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Ferrari, Pietro
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Boeing, Heiner
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Benetou, Vassili ...
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Trichopoulou, An ...
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Palli, Domenico
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Crosignani, Paol ...
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Tumino, Rosario
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Panico, Salvator ...
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Bueno-De-Mesquit ...
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Peeters, Petra H ...
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van Gib, Carla H ...
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Lund, Eiliv
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Gonzalez, Carlos ...
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Martinez, Carmen
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Dorronsoro, Mire ...
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Barricarte, Aure ...
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Navarro, Carmen
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Quiros, Jose R.
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Berglund, Göran
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Jarvholm, Bengt
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Khaw, Kay Tee
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Key, Timothy J.
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Bingham, Sheila
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Jose Diaz, Tormo ...
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Riboli, Elio
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Matullo, Giusepp ...
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Vineis, Paolo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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DNA Repair
- By the university
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Lund University
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Umeå University