Genome-wide meta-analyses identify multiple loci associated with smoking behavior

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Fältnamn	Indikatorer	Metadata
000		08145naa a2201705 4500
001		oai:lup.lub.lu.se:e24186cf-b864-4612-9009-34dafc946a18
003		SwePub
008		160401s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/16191892 URI
024	7	a https://doi.org/10.1038/ng.5712 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Furberg, Helena4 aut
245	1 0	a Genome-wide meta-analyses identify multiple loci associated with smoking behavior
264		c 2010-04-25
264	1	b Springer Science and Business Media LLC,c 2010
520		a Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], b = 1.03, standard error (s.e.) = 0.053, beta = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], b = 0.367, s. e. = 0.059, beta = 5.7 x 10(-10); and rs1028936[A], b = 0.446, s. e. = 0.074, beta = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], b = 0.333, s. e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Kim, YunJung4 aut
700	1	a Dackor, Jennifer4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Ardissino, Diego4 aut
700	1	a Bernardinelli, Luisa4 aut
700	1	a Mannucci, Pier M.4 aut
700	1	a Mauri, Francesco4 aut
700	1	a Merlini, Piera A.4 aut
700	1	a Absher, Devin4 aut
700	1	a Assimes, Themistocles L.4 aut
700	1	a Fortmann, Stephen P.4 aut
700	1	a Iribarren, Carlos4 aut
700	1	a Knowles, Joshua W.4 aut
700	1	a Quertermous, Thomas4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Tanaka, Toshiko4 aut
700	1	a Bis, Joshua C.4 aut
700	1	a Furberg, Curt D.4 aut
700	1	a Haritunians, Talin4 aut
700	1	a McKnight, Barbara4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Taylor, Kent D.4 aut
700	1	a Thacker, Evan L.4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-pal
700	1	a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
700	1	a Ladenvall, Claesu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-cll
700	1	a Boehnke, Michael4 aut
700	1	a Jackson, Anne U.4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Stringham, Heather M.4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Benjamin, Emelia J.4 aut
700	1	a Hwang, Shih-Jen4 aut
700	1	a Levy, Daniel4 aut
700	1	a Preis, Sarah Rosner4 aut
700	1	a Vasan, Ramachandran S.4 aut
700	1	a Duan, Jubao4 aut
700	1	a Gejman, Pablo V.4 aut
700	1	a Levinson, Douglas F.4 aut
700	1	a Sanders, Alan R.4 aut
700	1	a Shi, Jianxin4 aut
700	1	a Lips, Esther H.4 aut
700	1	a Mckay, James D.4 aut
700	1	a Agudo, Antonio4 aut
700	1	a Barzan, Luigi4 aut
700	1	a Bencko, Vladimir4 aut
700	1	a Benhamou, Simone4 aut
700	1	a Castellsague, Xavier4 aut
700	1	a Canova, Cristina4 aut
700	1	a Conway, David I.4 aut
700	1	a Fabianova, Eleonora4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Healy, Claire M.4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Kjaerheim, Kristina4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Lowry, Ray4 aut
700	1	a Macfarlane, Tatiana V.4 aut
700	1	a Mates, Dana4 aut
700	1	a Richiardi, Lorenzo4 aut
700	1	a Rudnai, Peter4 aut
700	1	a Szeszenia-Dabrowska, Neonilia4 aut
700	1	a Zaridze, David4 aut
700	1	a Znaor, Ariana4 aut
700	1	a Lathrop, Mark4 aut
700	1	a Brennan, Paul4 aut
700	1	a Bandinelli, Stefania4 aut
700	1	a Frayling, Timothy M.4 aut
700	1	a Guralnik, Jack M.4 aut
700	1	a Milaneschi, Yuri4 aut
700	1	a Perry, John R. B.4 aut
700	1	a Altshuler, David4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Kathiresan, Sek4 aut
700	1	a Lucas, Gavin4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a O'Donnell, Christopher J.4 aut
700	1	a Salomaa, Veikko4 aut
700	1	a Schwartz, Stephen M.4 aut
700	1	a Voight, Benjamin F.4 aut
700	1	a Penninx, Brenda W.4 aut
700	1	a Smit, Johannes H.4 aut
700	1	a Vogelzangs, Nicole4 aut
700	1	a Boomsma, Dorret I.4 aut
700	1	a de Geus, Eco J. C.4 aut
700	1	a Vink, Jacqueline M.4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Gu, Fangyi4 aut
700	1	a Hankinson, Susan E.4 aut
700	1	a Hunter, David J.4 aut
700	1	a Hofman, Albert4 aut
700	1	a Tiemeier, Henning4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Walter, Stefan4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Everett, Brendan M.4 aut
700	1	a Pare, Guillaume4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Li, Ming D.4 aut
700	1	a Maes, Hermine H.4 aut
700	1	a Audrain-McGovern, Janet4 aut
700	1	a Posthuma, Danielle4 aut
700	1	a Thornton, Laura M.4 aut
700	1	a Lerman, Caryn4 aut
700	1	a Kaprio, Jaakko4 aut
700	1	a Rose, Jed E.4 aut
700	1	a Ioannidis, John P. A.4 aut
700	1	a Kraft, Peter4 aut
700	1	a Lin, Dan-Yu4 aut
700	1	a Sullivan, Patrick F.4 aut
710	2	a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 42:5, s. 134-441q 42:5<134-441x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.571y FULLTEXT
856	4	u https://europepmc.org/articles/pmc2914600?pdf=render
856	4 8	u https://lup.lub.lu.se/record/1619189
856	4 8	u https://doi.org/10.1038/ng.571

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Av författaren/redakt...: Furberg, Helena; Kim, YunJung; Dackor, Jennifer; Boerwinkle, Eric; Franceschini, No ...; Ardissino, Diego; visa fler...; Bernardinelli, L ...; Mannucci, Pier M ...; Mauri, Francesco; Merlini, Piera A ...; Absher, Devin; Assimes, Themist ...; Fortmann, Stephe ...; Iribarren, Carlo ...; Knowles, Joshua ...; Quertermous, Tho ...; Ferrucci, Luigi; Tanaka, Toshiko; Bis, Joshua C.; Furberg, Curt D.; Haritunians, Tal ...; McKnight, Barbar ...; Psaty, Bruce M.; Taylor, Kent D.; Thacker, Evan L.; Almgren, Peter; Groop, Leif; Ladenvall, Claes; Boehnke, Michael; Jackson, Anne U.; Mohlke, Karen L.; Stringham, Heath ...; Tuomilehto, Jaak ...; Benjamin, Emelia ...; Hwang, Shih-Jen; Levy, Daniel; Preis, Sarah Ros ...; Vasan, Ramachand ...; Duan, Jubao; Gejman, Pablo V.; Levinson, Dougla ...; Sanders, Alan R.; Shi, Jianxin; Lips, Esther H.; Mckay, James D.; Agudo, Antonio; Barzan, Luigi; Bencko, Vladimir; Benhamou, Simone; Castellsague, Xa ...; Canova, Cristina; Conway, David I.; Fabianova, Eleon ...; Foretova, Lenka; Janout, Vladimir; Healy, Claire M.; Holcatova, Ivana; Kjaerheim, Krist ...; Lagiou, Pagona; Lissowska, Jolan ...; Lowry, Ray; Macfarlane, Tati ...; Mates, Dana; Richiardi, Loren ...; Rudnai, Peter; Szeszenia-Dabrow ...; Zaridze, David; Znaor, Ariana; Lathrop, Mark; Brennan, Paul; Bandinelli, Stef ...; Frayling, Timoth ...; Guralnik, Jack M ...; Milaneschi, Yuri; Perry, John R. B ...; Altshuler, David; Elosua, Roberto; Kathiresan, Sek; Lucas, Gavin; Melander, Olle; O'Donnell, Chris ...; Salomaa, Veikko; Schwartz, Stephe ...; Voight, Benjamin ...; Penninx, Brenda ...; Smit, Johannes H ...; Vogelzangs, Nico ...; Boomsma, Dorret ...; de Geus, Eco J. ...; Vink, Jacqueline ...; Willemsen, Gonne ...; Chanock, Stephen ...; Gu, Fangyi; Hankinson, Susan ...; Hunter, David J.; Hofman, Albert; Tiemeier, Hennin ...; Uitterlinden, An ...; van Duijn, Corne ...; Walter, Stefan; Chasman, Daniel ...; Everett, Brendan ...; Pare, Guillaume; Ridker, Paul M.; Li, Ming D.; Maes, Hermine H.; Audrain-McGovern ...; Posthuma, Daniel ...; Thornton, Laura ...; Lerman, Caryn; Kaprio, Jaakko; Rose, Jed E.; Ioannidis, John ...; Kraft, Peter; Lin, Dan-Yu; Sullivan, Patric ...; visa färre...

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