A polymorphism within IL21R confers risk for systemic lupus erythematosus

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Fältnamn	Indikatorer	Metadata
000		03204naa a2200577 4500
001		oai:DiVA.org:uu-122921
003		SwePub
008		100421s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1229212 URI
024	7	a https://doi.org/10.1002/art.246582 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Webb, Ryan4 aut
245	1 0	a A polymorphism within IL21R confers risk for systemic lupus erythematosus
264	1	b Wiley,c 2009
338		a print2 rdacarrier
520		a OBJECTIVE: Interleukin-21 (IL-21) is a member of the type I cytokine superfamily that has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. The expression of IL-21 receptor (IL-21R) is reduced in the B cells of patients with systemic lupus erythematosus (SLE), while serum IL-21 levels are increased both in lupus patients and in some murine lupus models. We recently reported that polymorphisms within the IL21 gene are associated with increased susceptibility to SLE. The aim of this study was to examine the genetic association between single-nucleotide polymorphisms (SNPs) within IL21R and SLE. METHODS: We genotyped 17 SNPs in the IL21R gene in 2 large cohorts of lupus patients (a European-derived cohort and a Hispanic cohort) and in ethnically matched healthy controls. RESULTS: We identified and confirmed the association between rs3093301 within the IL21R gene and SLE in the 2 cohorts (meta-analysis odds ratio 1.16 [95% confidence interval 1.08-1.25], P=1.0x10(-4)). CONCLUSION: Our findings indicate that IL21R is a novel susceptibility gene for SLE.
653		a MEDICINE
653		a MEDICIN
700	1	a Merrill, Joan T4 aut
700	1	a Kelly, Jennifer A4 aut
700	1	a Sestak, Andrea4 aut
700	1	a Kaufman, Kenneth M4 aut
700	1	a Langefeld, Carl D4 aut
700	1	a Ziegler, Julie4 aut
700	1	a Kimberly, Robert P4 aut
700	1	a Edberg, Jeffrey C4 aut
700	1	a Ramsey-Goldman, Rosalind4 aut
700	1	a Petri, Michelle4 aut
700	1	a Reveille, John D4 aut
700	1	a Alarcón, Graciela S4 aut
700	1	a Vilá, Luis M4 aut
700	1	a Alarcón-Riquelme, Marta Eu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala
700	1	a James, Judith A4 aut
700	1	a Gilkeson, Gary S4 aut
700	1	a Jacob, Chaim O4 aut
700	1	a Moser, Kathy L4 aut
700	1	a Gaffney, Patrick M4 aut
700	1	a Vyse, Timothy J4 aut
700	1	a Nath, Swapan K4 aut
700	1	a Lipsky, Peter4 aut
700	1	a Harley, John B4 aut
700	1	a Sawalha, Amr H4 aut
710	2	a Uppsala universitetb Institutionen för genetik och patologi4 org
773	0	t Arthritis and Rheumatismd : Wileyg 60:8, s. 2402-2407q 60:8<2402-2407x 0004-3591x 1529-0131
856	4	u https://europepmc.org/articles/pmc2782592?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122921
856	4 8	u https://doi.org/10.1002/art.24658

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