Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis

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Fältnamn	Indikatorer	Metadata
000		03058naa a2200409 4500
001		oai:lup.lub.lu.se:9961a15b-c306-4da8-a84f-047ef6846fdd
003		SwePub
008		160401s2005 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-5438
024	7	a https://lup.lub.lu.se/record/2576532 URI
024	7	a https://doi.org/10.1016/j.bmc.2004.10.0112 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-54382 URI
040		a (SwePub)lud (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Holm, Lu Umeå universitet,Kemiska institutionen4 aut
245	1 0	a Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis
264	1	a Oxford :b Elsevier BV,c 2005
520		a Collagen induced arthritis (CIA) is a common mouse model for rheumatoid arthritis. Two sets of truncated peptides derived from type II collagen have been prepared and tested for binding to A(q), a MHC-II molecule associated with development of CIA. Binding to A(q) correlated well with predictions from a computer-based model. T-cell hybridomas, obtained in CIA, were also used to study the ability of A(q) bound peptides to trigger a T-cell response. The minimal peptide epitope required for binding, as well as for giving a T-cell response, was determined to be CII260-267. In collagen this epitope is often glycosylated at hydroxylysine 264 and glycosylation has been shown to be an immunodominant feature in CIA. Synthesis and evaluation of CII260-267 carrying a beta-D-galactosyl moiety at position 264 revealed that this glycopeptide stimulated representative members from a panel of carbohydrate-specific T-cell hybridomas obtained in CIA.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653		a T cell
653		a glycopeptide
653		a collagen
653		a rheumatoid arthritis
653		a Glycopeptide
700	1	a Kjellen, Pu Section of Medical Inflammation Research, Lund University, Lund, Sweden4 aut
700	1	a Holmdahl, Rikardu Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Section of Medical Inflammation Research, Lund University, Lund, Sweden4 aut0 (Swepub:lu)infl-rho
700	1	a Kihlberg, Ju Umeå universitet,Kemiska institutionen4 aut
710	2	a Umeå universitetb Kemiska institutionen4 org
773	0	t Bioorganic & Medicinal Chemistryd Oxford : Elsevier BVg 13:2, s. 473-482q 13:2<473-482x 0968-0896x 1464-3391
856	4	u http://dx.doi.org/10.1016/j.bmc.2004.10.011y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/257653
856	4 8	u https://doi.org/10.1016/j.bmc.2004.10.011
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-5438

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By the author/editor: Holm, L; Kjellen, P; Holmdahl, Rikard; Kihlberg, J

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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By the university: Lund University; Umeå University

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