Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins

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Fältnamn	Indikatorer	Metadata
000		02983naa a2200361 4500
001		oai:DiVA.org:umu-35270
003		SwePub
008		100811s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:120868293
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-352702 URI
024	7	a https://doi.org/10.1039/c003640d2 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1208682932 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Andersson, Ida E.,d 1982-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)idaann02
245	1 0	a Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins
264	1	b RSC Publishing,c 2010
338		a print2 rdacarrier
520		a The glycopeptide CII259-273, a fragment from type II collagen (CII), can induce tolerance in mice susceptible to collagen-induced arthritis (CIA), which is a validated disease model for rheumatoid arthritis (RA). Here, we describe the design and synthesis of a small series of modified CII259-273 glycopeptides with oxazole heterocycles replacing three potentially labile peptide bonds. These glycopeptidomimetics were evaluated for binding to murine CIA-associated A(q) and human RA-associated DR4 class II major histocompatibility complex (MHC) proteins. The oxazole modifications drastically reduced or completely abolished binding to A(q). Two of the glycopeptidomimetics were, however, well tolerated in binding to DR4 and they also induced strong responses by one or two DR4-restricted T-cell hybridomas. This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA.
700	1	a Batsalova, Tsvetelinau Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut
700	1	a Dzhambazov, Baliku Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut
700	1	a Edvinsson, Lottau Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)loed0002
700	1	a Holmdahl, Rikardu Karolinska Institutet4 aut
700	1	a Kihlberg, Jan,d 1957-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)jaki0001
700	1	a Linusson, Anna,d 1970-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)analin99
710	2	a Umeå universitetb Kemiska institutionen4 org
773	0	t Organic and biomolecular chemistryd : RSC Publishingg 8:13, s. 2931-2940q 8:13<2931-2940x 1477-0520x 1477-0539
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35270
856	4 8	u https://doi.org/10.1039/c003640d
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:120868293

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Av författaren/redakt...: Andersson, Ida E ...; Batsalova, Tsvet ...; Dzhambazov, Bali ...; Edvinsson, Lotta; Holmdahl, Rikard; Kihlberg, Jan, 1 ...; visa fler...; Linusson, Anna, ...; visa färre...

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Av lärosätet: Umeå universitet; Karolinska Institutet

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