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Genetic Imbalance I...
Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke
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- Pfeiffer, Dorothea (författare)
- University Hospital Heidelberg
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- Chen, Bowang (författare)
- Southern University of Science and Technology
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- Schlicht, Kristina (författare)
- University Medical Center Schleswig-Holstein,University of Kiel
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- Ginsbach, Philip (författare)
- University of Edinburgh
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- Abboud, Sherine (författare)
- Université Libre de Bruxelles (ULB)
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- Bersano, Anna (författare)
- Carlo Besta Neurological Institute, IRCCS
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- Bevan, Steve (författare)
- University of Lincoln
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- Brandt, Tobias (författare)
- Suva/Swiss National Accident Insurance Fund,University Hospital Heidelberg
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- Caso, Valeria (författare)
- Ospedale Santa Maria della Misericordia
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- Debette, Stéphanie (författare)
- University of Bordeaux,Centre Hospitalier Universitaire de Bordeaux
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- Erhart, Philipp (författare)
- University Hospital Heidelberg
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- Freitag-Wolf, Sandra (författare)
- University of Kiel,University Medical Center Schleswig-Holstein
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- Giacalone, Giacomo (författare)
- San Raffaele Hospital
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- Grau, Armin J. (författare)
- Klinikum Ludwigshafen
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- Hayani, Eyad (författare)
- University Hospital Heidelberg
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- Jern, Christina (författare)
- University of Gothenburg,Sahlgrenska University Hospital
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- Jiménez-Conde, Jordi (författare)
- Autonomous University of Barcelona
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- Kloss, Manja (författare)
- University Hospital Heidelberg
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- Krawczak, Michael (författare)
- University of Kiel,University Medical Center Schleswig-Holstein
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- Lee, Jin Moo (författare)
- Washington University in St. Louis
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- Lemmens, Robin (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Leys, Didier (författare)
- University of Lille
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- Lichy, Christoph (författare)
- Municipal Hospital Memmingen
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- Maguire, Jane M. (författare)
- University of Newcastle,University of Technology Sydney
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- Martin, Juan J. (författare)
- Sanatorio Allende De Córdoba
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- Metso, Antti J. (författare)
- Helsinki University Central Hospital
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- Metso, Tiina M. (författare)
- Helsinki University Central Hospital
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- Mitchell, Braxton D. (författare)
- University of Maryland,Baltimore Veterans Administration Medical Center
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- Pezzini, Alessandro (författare)
- University of Brescia
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- Rosand, Jonathan (författare)
- Massachusetts General Hospital
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- Rost, Natalia S. (författare)
- Massachusetts General Hospital
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- Stenman, Martin (författare)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Tatlisumak, Turgut (författare)
- University of Gothenburg,Sahlgrenska University Hospital,Helsinki University Central Hospital
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- Thijs, Vincent (författare)
- Austin Health,University of Melbourne
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- Touzé, Emmanuel (författare)
- University of Caen Normandy,Centre Hospitalier Sainte-Anne
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- Traenka, Christopher (författare)
- University Hospital Basel
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- Werner, Inge (författare)
- University Hospital Heidelberg
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- Woo, Daniel (författare)
- University of Cincinnati
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- Del Zotto, Elisabetta (författare)
- University of Brescia
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- Engelter, Stefan T. (författare)
- University Hospital Basel,University of Basel,Felix Platter Hospital
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- Kittner, Steven J. (författare)
- University of Maryland,Baltimore Veterans Administration Medical Center
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- Cole, John W. (författare)
- University of Maryland,Baltimore Veterans Administration Medical Center
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- Grond-Ginsbach, Caspar (författare)
- University Hospital Heidelberg
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- Lyrer, Philippe A. (författare)
- University Hospital Basel
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- Lindgren, Arne (författare)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups
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(creator_code:org_t)
- 2019
- 2019
- Engelska 7 s.
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Ingår i: Stroke. - 1524-4628. ; 50:2, s. 298-304
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and Purpose- We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods- Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affected by copy number variations in an individual, was compared between patients with favorable (modified Rankin Scale score of 0-2) and unfavorable (modified Rankin Scale score of ≥3) outcome after 3 months. Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results- The study sample comprised 816 CADISP patients (age 44.2±10.3 years) and 2498 SiGN/GISCOME patients (age 67.7±14.2 years). Outcome was unfavorable in 122 CADISP and 889 SiGN/GISCOME patients. Multivariate logistic regression analysis revealed that increased genetic imbalance was associated with less favorable outcome in both samples (CADISP: P=0.0007; odds ratio=0.89; 95% CI, 0.82-0.95 and SiGN/GISCOME: P=0.0036; odds ratio=0.94; 95% CI, 0.91-0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80-0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89-0.98) whereas imbalance without ohnologs lacked such an association. Conclusions- Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- DNA copy number variations
- genetics
- polymorphism, single nucleotide
- prognosis
- stroke
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Stroke
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Till lärosätets databas
- Av författaren/redakt...
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Pfeiffer, Doroth ...
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Chen, Bowang
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Schlicht, Kristi ...
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Ginsbach, Philip
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Abboud, Sherine
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Bersano, Anna
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visa fler...
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Bevan, Steve
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Brandt, Tobias
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Caso, Valeria
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Debette, Stéphan ...
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Erhart, Philipp
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Freitag-Wolf, Sa ...
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Giacalone, Giaco ...
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Grau, Armin J.
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Hayani, Eyad
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Jern, Christina
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Jiménez-Conde, J ...
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Kloss, Manja
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Krawczak, Michae ...
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Lee, Jin Moo
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Lemmens, Robin
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Leys, Didier
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Lichy, Christoph
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Maguire, Jane M.
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Martin, Juan J.
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Metso, Antti J.
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Metso, Tiina M.
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Mitchell, Braxto ...
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Pezzini, Alessan ...
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Rosand, Jonathan
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Rost, Natalia S.
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Stenman, Martin
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Tatlisumak, Turg ...
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Thijs, Vincent
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Touzé, Emmanuel
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Traenka, Christo ...
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Werner, Inge
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Woo, Daniel
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Del Zotto, Elisa ...
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Engelter, Stefan ...
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Kittner, Steven ...
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Cole, John W.
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Grond-Ginsbach, ...
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Lyrer, Philippe ...
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Lindgren, Arne
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Stroke
- Av lärosätet
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Lunds universitet