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WFRF:(Koch Holger M.)
 

Sökning: WFRF:(Koch Holger M.) > Engineering Genetic...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00010759naa a2200781 4500
001oai:DiVA.org:uu-394687
003SwePub
008191024s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3946872 URI
0247 a https://doi.org/10.1016/j.stem.2019.05.0132 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Huang, Milleru Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
2451 0a Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis
264 1b CELL PRESS,c 2019
338 a electronic2 rdacarrier
520 a Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines is uncertain. Here, we evaluated neuroepithelial stem (NES) cells, representative of cerebellar progenitors. We transduced NES cells with MYCN, observing medulloblastoma upon orthotopic implantation in mice. Significantly, transcriptomes and patterns of DNA methylation from xenograft tumors were globally more representative of human medulloblastoma compared to a MYCN-driven genetically engineered mouse model. Orthotopic transplantation of NES cells generated from Gorlin syndrome patients, who are predis- posed to medulloblastoma due to germline-mutated PTCH1, also generated medulloblastoma. We engineered candidate cooperating mutations in Gorlin NES cells, with mutation of DDX3X or loss of GSE1 both accelerating tumorigenesis. These findings demonstrate that human NES cells provide a potent experimental resource for dissecting genetic causation in medulloblastoma.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
7001 a Tailor, Jigneshu Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England;Inst Canc Res, London SM2 5NG, England;Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada4 aut
7001 a Zhen, Qiqiu Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Gillmor, Aaron H.u Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada;Univ Calgary, Charbonneau Canc Inst, Calgary, AB, Canada;Alberta Childrens Prov Gen Hosp, Res Inst, Calgary, AB, Canada4 aut
7001 a Miller, Matthew L.u Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Weishaupt, Holgeru Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)holwe849
7001 a Chen, Justinu Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA4 aut
7001 a Zheng, Tinau Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Nash, Emily K.u Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a McHenry, Lauren K.u Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a An, Zhenyiu Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Ye, Fubaiyangu Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Takashima, Yasuhirou Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England4 aut
7001 a Clarke, Jamesu Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England4 aut
7001 a Ayetey, Haroldu Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England4 aut
7001 a Cavalli, Florence Mgu Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada4 aut
7001 a Luu, Bettyu Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada4 aut
7001 a Moriarity, Branden S.u Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA;Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA4 aut
7001 a Ilkhanizadeh, Shirinu Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA4 aut
7001 a Chavez, Lukasu Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany4 aut
7001 a Yu, Chunyingu Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada4 aut
7001 a Kurian, Kathreena M.u Univ Bristol, Southmead Hosp, Inst Clin Neurosci, Level 1,Learning & Res Bldg, Bristol BS10 5NB, Avon, England4 aut
7001 a Magnaldo, Thierryu Nice UMR CNRS 7284 INSERM U1081 UNS UCA, Inst Res Canc & Aging, Nice, France4 aut
7001 a Sevenet, Nicolasu Univ Bordeaux, Inst Bergonie, 229 Cours Argonne, F-33076 Bordeaux, France;Univ Bordeaux, INSERM U1218, 229 Cours Argonne, F-33076 Bordeaux, France4 aut
7001 a Koch, Philippu Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Mannheim, Germany;Hector Inst Translat Brain Res HITBR gGmbH, Mannheim, Germany;German Canc Res Ctr, Heidelberg, Germany4 aut
7001 a Pollard, Steven M.u Univ Edinburgh, MRC Ctr Regenerat Med, Edinburgh, Midlothian, Scotland;Univ Edinburgh, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland4 aut
7001 a Dirks, Peteru Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada4 aut
7001 a Snyder, Michael P.u Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA4 aut
7001 a Largaespada, David A.u Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA;Univ Minnesota, Ctr Genome Engn, Minneapolis, MN 55455 USA;Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA4 aut
7001 a Cho, Yoon Jaeu Oregon Hlth & Sci Univ, Dept Pediat, Div Pediat Neurol, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA;Oregon Hlth & Sci Univ, Dept Pediat, Pape Family Pediat Res Inst, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA;Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA4 aut
7001 a Phillips, Joanna J.u Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94158 USA;Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94158 USA4 aut
7001 a Johansson Swartling, Fredrik,d 1975-u Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi4 aut0 (Swepub:uu)fredjoha
7001 a Morrissy, A. Soranau Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada;Univ Calgary, Charbonneau Canc Inst, Calgary, AB, Canada;Alberta Childrens Prov Gen Hosp, Res Inst, Calgary, AB, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada4 aut
7001 a Kool, Marcelu Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany4 aut
7001 a Pfister, Stefan M.u Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany;German Canc Consortium DKTK, Div Pediat Neurooncol, German Canc Res Ctr DKFZ, Heidelberg, Germany;Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, Heidelberg, Germany4 aut
7001 a Taylor, Michael D.u Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada;Hosp Sick Children, Arthur & Sonia Labatt Brain Tumour Res Ctr, Toronto, ON, Canada;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada4 aut
7001 a Smith, Austinu Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England4 aut
7001 a Weiss, William A.u Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Pediat, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Neurosurg, San Francisco, CA 94158 USA;Univ Calif San Francisco, Res Ctr, Dept Brain Tumor, San Francisco, CA 94158 USA4 aut
7102 a Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA;Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94158 USAb Univ Cambridge, MRC Stem Cell Inst, Wellcome Trust, Tennis Court Rd, Cambridge CB2 1QR, England;Inst Canc Res, London SM2 5NG, England;Hosp Sick Children, Dev & Stem Cell Biol Program, Toronto, ON, Canada;Hosp Sick Children, Div Neurosurg, Toronto, ON, Canada4 org
7730 t Cell Stem Celld : CELL PRESSg 25:3, s. 433-+q 25:3<433-+x 1934-5909x 1875-9777
8564 u https://doi.org/10.1016/j.stem.2019.05.013y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1365321/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.cell.com/article/S1934590919302176/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-394687
8564 8u https://doi.org/10.1016/j.stem.2019.05.013

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