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WFRF:(Koch Manuel)
 

Sökning: WFRF:(Koch Manuel) > Collagen XII and XI...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003295naa a2200397 4500
001oai:lup.lub.lu.se:461fccc4-1c7a-4f1a-9b73-218dfee66370
003SwePub
008160401s2012 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/29917002 URI
0247 a https://doi.org/10.1074/jbc.M111.3359352 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Agarwal, Pallavi4 aut
2451 0a Collagen XII and XIV, New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure
264 1c 2012
520 a The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and supports the epidermis. In the skin, collagen I fibrils are the major structural component of the dermal ECM, decorated by proteoglycans and by fibril-associated collagens with interrupted triple helices such as collagens XII and XIV. Here we show that the cartilage oligomeric matrix protein (COMP), an abundant component of cartilage ECM, is expressed in healthy human skin. COMP expression is detected in the dermal compartment of skin and in cultured fibroblasts, whereas epidermis and HaCaT cells are negative. In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains. All three proteins codistribute in a characteristic narrow zone in the superficial papillary dermis of healthy human skin. Ultrastructural analysis by immunogold labeling confirmed colocalization and further revealed the presence of COMP along with collagens XII and XIV in anchoring plaques. On the basis of these observations, we postulate that COMP functions as an adapter protein in human skin, similar to its function in cartilage ECM, by organizing collagen I fibrils into a suprastructure, mainly in the vicinity of anchoring plaques that stabilize the cohesion between the upper dermis and the basement membrane zone.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Zwolanek, Daniela4 aut
7001 a Keene, Douglas R.4 aut
7001 a Schulz, Jan-Niklas4 aut
7001 a Blumbach, Katrin4 aut
7001 a Heinegård, Dicku Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-dhe
7001 a Zaucke, Frank4 aut
7001 a Paulsson, Mats4 aut
7001 a Krieg, Thomas4 aut
7001 a Koch, Manuel4 aut
7001 a Eckes, Beate4 aut
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t Journal of Biological Chemistryg 287:27, s. 22549-22559q 287:27<22549-22559x 1083-351X
8564 u http://dx.doi.org/10.1074/jbc.M111.335935y FULLTEXT
8564 8u https://lup.lub.lu.se/record/2991700
8564 8u https://doi.org/10.1074/jbc.M111.335935

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