Efficient prediction of human protein-protein interactions at a global scale

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Efficient prediction of human protein-protein interactions at a global scale

Schoenrock, A. (author): Carleton University, Ottawa, Canada

Samanfar, B. (author): Carleton University, Ottawa, Canada

Pitre, S. (author): Carleton University, Ottawa, Canada

Hooshyar, M. (author): Carleton University, Ottawa, Canada

Jin, K. (author): University of Toronto, Toronto, Canada

Phillips, C. A. (author): University of Tennessee, Knoxville, Tennessee, USA

Wang, Hui (author): Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication

Phanse, S. (author): University of Toronto, Toronto, Canada

Omidi, K. (author): University of Toronto, Toronto, Canada

Gui, Y. (author): University of Toronto, Toronto, Canada

Alamgir, M. (author): University of Toronto, Toronto, Canada,Carleton University, Ottawa, Canada

Wong, A. (author): University of Toronto, Toronto, Canada

Barrenäs, Fredrik, 1981 (author): Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication

Babu, M. (author): University of Regina, Regina, Saskatchewan, Canada

Benson, Mikael, 1954 (author): Östergötlands Läns Landsting,Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Allergicentrum US,Barn- och ungdomskliniken i Linköping,Gothenburg University, Gothenburg, Sweden,The Centre for Individualized Medication

Langston, M. A. (author)

Green, J. R. (author): Carleton University, Ottawa, Canada

Dehne, F. (author): Carleton University, Ottawa, Canada

Golshani, A. (author): Carleton University, Ottawa, Canada

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2014-12-10
2014
English.
In: Bmc Bioinformatics. - : Springer Science and Business Media LLC. - 1471-2105. ; 15

Related links:: https://bmcbioinform...; show more...; https://liu.diva-por... (primary) (Raw object); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods. Results: On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range of experiments. Conclusions: The speed and accuracy associated with MP-PIPE can make this a potential tool to study individual human PPI networks (from genomic sequences alone) for personalized medicine.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

Keyword

Protein-protein interactions
Computational prediction
Human proteome
Massively parallel
YEAST SACCHAROMYCES-CEREVISIAE
SHORT POLYPEPTIDE SEQUENCES
INTERACTION
NETWORKS
ALLERGIC RHINITIS
DNA-DAMAGE
COMPUTATIONAL METHODS
MESSENGER-RNA
BREAST-CANCER
AURORA B
DISEASE
Biochemical Research Methods
Biotechnology & Applied Microbiology
Mathematical & Computational Biology

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Schoenrock, A.; Samanfar, B.; Pitre, S.; Hooshyar, M.; Jin, K.; Phillips, C. A.; show more...; Wang, Hui; Phanse, S.; Omidi, K.; Gui, Y.; Alamgir, M.; Wong, A.; Barrenäs, Fredri ...; Babu, M.; Benson, Mikael, ...; Langston, M. A.; Green, J. R.; Dehne, F.; Golshani, A.; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...

Articles in the publication: Bmc Bioinformati ...

By the university: University of Gothenburg; Linköping University

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