How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

Ledri, Marco (författare): Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital,Hungarian Academy of Sciences

Kokaia, Merab (författare): Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital

Scharfman, Helen E. (redaktör/utgivare)

Buckmaster, Paul S. (redaktör/utgivare)

(creator_code:org_t)

2014-05-14
2014
Engelska.
Ingår i: Issues in Clinical Epileptology: A View From the Bench. - Dordrecht : Springer Netherlands. - 0065-2598. - 9789401789141 ; 813, s. 319-336

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Abstract Ämnesord

Stäng

Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research.

Av författaren/redakt...: Krook-Magnuson, ...; Ledri, Marco; Soltesz, Ivan; Kokaia, Merab; Scharfman, Helen ...; Buckmaster, Paul ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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