How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?

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MARC

Fältnamn	Indikatorer	Metadata
000		03227naa a2200457 4500
001		oai:lup.lub.lu.se:218e2095-0a68-4597-a670-a83c11a58baa
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/49625052 URI
024	7	a https://doi.org/10.1007/978-94-017-8914-1_262 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a kap2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Krook-Magnuson, Estheru University of California System4 aut
245	1 0	a How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?
264		c 2014-05-14
264	1	a Dordrecht :b Springer Netherlands,c 2014
520		a Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653		a On-demand
653		a Responsive
653		a Channelrhodopsin
653		a Halorhodopsin
653		a Arch
653		a AAV
653		a Optrode
653		a Seizure
700	1	a Ledri, Marcou Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital,Hungarian Academy of Sciences4 aut0 (Swepub:lu)ma6384le
700	1	a Soltesz, Ivanu University of California System4 aut
700	1	a Kokaia, Merabu Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)neur-mko
700	1	a Scharfman, Helen E.4 edt
700	1	a Buckmaster, Paul S.4 edt
710	2	a University of California Systemb Experimentell Epilepsi4 org
773	0	t Issues in Clinical Epileptology: A View From the Benchd Dordrecht : Springer Netherlandsg 813, s. 319-336q 813<319-336x 0065-2598z 9789401789141
856	4	u http://dx.doi.org/10.1007/978-94-017-8914-1_26y FULLTEXT
856	4	u https://europepmc.org/articles/pmc4968566?pdf=render
856	4 8	u https://lup.lub.lu.se/record/4962505
856	4 8	u https://doi.org/10.1007/978-94-017-8914-1_26

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