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Primary fatty amide...
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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- Kim, Min (författare)
- Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Snowden, Stuart (författare)
- Institute of Pharmaceutical Science, King's College London, London, UK; Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK
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- Suvitaival, Tommi (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Ali, Ashfaq (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Merkler, David J (författare)
- Department of Chemistry, University of South Florida, Tampa, FL, USA
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- Ahmad, Tahmina (författare)
- Institute of Pharmaceutical Science, King's College London, London, UK
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- Westwood, Sarah (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Baird, Alison (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Proitsi, Petroula (författare)
- Karolinska Institutet
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- Nevado-Holgado, Alejo (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Hye, Abdul (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Bos, Isabelle (författare)
- Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Vos, Stephanie (författare)
- Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Vandenberghe, Rik (författare)
- University Hospital Leuven, Leuven, Belgium
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- Teunissen, Charlotte (författare)
- Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands
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- Ten Kate, Mara (författare)
- Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands
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- Scheltens, Philip (författare)
- Department of Neurology, Alzheimer Center, Amsterdam University Medical Centers, Amsterdam, The Netherlands
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- Gabel, Silvy (författare)
- University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
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- Meersmans, Karen (författare)
- University Hospital Leuven, Leuven, Belgium; Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
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- Blin, Olivier (författare)
- Service de Pharmacologie Clinique et Pharmacovigilance, Institut de Neurosciences des Systèmes, Aix Marseille University, APHM, INSERM, Marseille, France
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- Richardson, Jill (författare)
- Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK
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- De Roeck, Ellen (författare)
- Institute Born-Bunge, University of Antwerp, Antwerp, Belgium
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- Sleegers, Kristel (författare)
- Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Flanders, Belgium
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- Bordet, Régis (författare)
- University of Lille, INSERM, CHU, Degenerative and Vascular Cognitive Disorders, Lille, Lille, France
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- Rami, Lorena (författare)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain
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- Kettunen, Petronella (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Tsolaki, Magda (författare)
- First Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece
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- Verhey, Frans (författare)
- Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands
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- Sala, Isabel (författare)
- Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Lléo, Alberto (författare)
- Memory Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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- Peyratout, Gwendoline (författare)
- University Hospital of Lausanne, Lausanne, Switzerland
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- Tainta, Mikel (författare)
- CITA-Alzheimer Foundation, San Sebastian, Spain
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- Johannsen, Peter (författare)
- Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
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- Freund-Levi, Yvonne, 1956- (författare)
- Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Frölich, Lutz (författare)
- Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany
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- Dobricic, Valerija (författare)
- Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany
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- Engelborghs, Sebastiaan (författare)
- Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Germany; Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium
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- Frisoni, Giovanni B (författare)
- University of Geneva, Geneva, Switzerland
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- Molinuevo, José L (författare)
- Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clinic-IDIBAPS, Barcelona, Spain; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain
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- Wallin, Anders, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Popp, Julius (författare)
- University Hospital of Lausanne, Lausanne, Switzerland; Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland
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- Martinez-Lage, Pablo (författare)
- CITA-Alzheimer Foundation, San Sebastian, Spain
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- Bertram, Lars (författare)
- University of Lübeck, Lübeck, Germany
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- Barkhof, Frederik (författare)
- Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands
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- Ashton, Nicholas J. (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Streffer, Johannes (författare)
- Experimental Medicine, Janssen Pharmaceutical Companies, Beerse, Belgium
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- Visser, Pieter J (författare)
- Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands; Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam University Medical Centers, Amsterdam Neuroscience, Amsterdam, The Netherlands
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- Lovestone, Simon (författare)
- Department of Psychiatry, University of Oxford, Oxford, UK
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- Legido-Quigley, Cristina (författare)
- Institute of Pharmaceutical Science, King's College London, London, UK; Steno Diabetes Center Copenhagen, Gentofte, Denmark
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(creator_code:org_t)
- 2019-05-08
- 2019
- Engelska.
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Ingår i: Alzheimer's & Dementia. - : Elsevier. - 1552-5260 .- 1552-5279. ; 15:6, s. 817-827
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- INTRODUCTION: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.METHODS: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.RESULTS: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DISCUSSION: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer's disease
- Amyloid
- Biomarkers
- Brain volume measurements
- CSF
- Cognitive function measurements
- Dementia
- EMIF-AD
- Metabolomics
- Tau
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kim, Min
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Snowden, Stuart
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Suvitaival, Tomm ...
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Ali, Ashfaq
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Merkler, David J
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Ahmad, Tahmina
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visa fler...
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Westwood, Sarah
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Baird, Alison
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Proitsi, Petroul ...
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Nevado-Holgado, ...
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Hye, Abdul
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Bos, Isabelle
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Vos, Stephanie
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Vandenberghe, Ri ...
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Teunissen, Charl ...
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Ten Kate, Mara
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Scheltens, Phili ...
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Gabel, Silvy
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Meersmans, Karen
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Blin, Olivier
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Richardson, Jill
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De Roeck, Ellen
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Sleegers, Kriste ...
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Bordet, Régis
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Rami, Lorena
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Kettunen, Petron ...
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Tsolaki, Magda
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Verhey, Frans
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Sala, Isabel
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Lléo, Alberto
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Peyratout, Gwend ...
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Tainta, Mikel
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Johannsen, Peter
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Freund-Levi, Yvo ...
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Frölich, Lutz
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Dobricic, Valeri ...
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Engelborghs, Seb ...
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Frisoni, Giovann ...
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Molinuevo, José ...
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Wallin, Anders, ...
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Popp, Julius
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Martinez-Lage, P ...
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Bertram, Lars
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Barkhof, Frederi ...
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Ashton, Nicholas ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Streffer, Johann ...
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Visser, Pieter J
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Lovestone, Simon
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Legido-Quigley, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Alzheimer's & De ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Göteborgs universitet