WFRF:(Lentini Antonio)
Sökning: WFRF:(Lentini Antonio) > TCF/LEF dependent a...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02992naa a2200397 4500 | |
| 001 | oai:DiVA.org:liu-154326 | |
| 003 | SwePub | |
| 008 | 190204s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1543262 URI |
| 024 | 7 | a https://doi.org/10.15252/embj.2017988732 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Doumpas, Nikolaosu Univ Zurich, Switzerland4 aut |
| 245 | 1 0 | a TCF/LEF dependent and independent transcriptional regulation of Wnt/beta-catenin target genes |
| 264 | c 2018-11-13 | |
| 264 | 1 | b WILEY,c 2019 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies|EMBO long-term fellowship; University of Zurich; Knut and Alice Wallenberg Foundation | |
| 520 | a During canonical Wnt signalling, the activity of nuclear beta-catenin is largely mediated by the TCF/LEF family of transcription factors. To challenge this view, we used the CRISPR/Cas9 genome editing approach to generate HEK 293T cell clones lacking all four TCF/LEF genes. By performing unbiased whole transcriptome sequencing analysis, we found that a subset of beta-catenin transcriptional targets did not require TCF/LEF factors for their regulation. Consistent with this finding, we observed in a genome-wide analysis that beta-catenin occupied specific genomic regions in the absence of TCF/LEF. Finally, we revealed the existence of a transcriptional activity of beta-catenin that specifically appears when TCF/LEF factors are absent, and refer to this as beta-catenin-GHOST response. Collectively, this study uncovers a previously neglected modus operandi of beta-catenin that bypasses the TCF/LEF transcription factors. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 653 | a signalling pathways; TCF/LEF; transcription factors; Wnt signalling; beta-catenin | |
| 700 | 1 | a Lampart, Franziskau Univ Zurich, Switzerland4 aut |
| 700 | 1 | a Robinson, Mark D.u Univ Zurich, Switzerland4 aut |
| 700 | 1 | a Lentini, Antoniou Univ Zurich, Switzerland4 aut |
| 700 | 1 | a Nestor, Colmu Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten4 aut0 (Swepub:liu)colne37 |
| 700 | 1 | a Cantù, Claudiou Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Univ Zurich, Switzerland4 aut0 (Swepub:liu)claca29 |
| 700 | 1 | a Basler, Konradu Univ Zurich, Switzerland4 aut |
| 710 | 2 | a Univ Zurich, Switzerlandb Avdelningen för barns och kvinnors hälsa4 org |
| 773 | 0 | t EMBO Journald : WILEYg 38:2q 38:2x 0261-4189x 1460-2075 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.201798873 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154326 |
| 856 | 4 8 | u https://doi.org/10.15252/embj.201798873 |
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